Shalaka Wahane

Bioengineering Organoids for Disease Modeling and Drug Discovery

Shalaka Wahane, Muhammad Nihad, Anubhab Mukherjee, Chrianjay Mukhopadhyay et autres

Organoid technology has been used to model diseases across different organ systems, drug screening, and regenerative medicine. Organoid technology better mimics human physiology and can provide a better alternative to in vivo animal models. Recent advances in organoid technology, including developing the …

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Optogenetics-enabled discovery of integrated stress response modulators

Felix Wong, Alicia Li, Satotaka Omori, Ryan S. Lach et autres

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Glioblastoma shift from bulk to infiltrative growth is guided by plexin-B2-mediated microglia alignment in invasive niches

Sangjo Kang, Mary E. Ughetta, Jack Yin Zhang, Valerie J. Marallano et autres

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Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease

Yong Huang, Minghui Wang, Haofei Ni, Jinglong Zhang et autres

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Author Correction: Divergent transcriptional regulation of astrocyte reactivity across disorders

Joshua E. Burda, Timothy Mark O’Shea, Yan Ao, Keshav B. Suresh et autres

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Divergent transcriptional regulation of astrocyte reactivity across disorders

Joshua E. Burda, Timothy Mark O’Shea, Yan Ao, Keshav B. Suresh et autres

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Correction to: Loss‑of‑function manipulations to identify roles of diverse glia and stromal cells during CNS scar formation

Shalaka Wahane, Michael V. Sofroniew

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RNA Profiling of Mouse Ependymal Cells after Spinal Cord Injury Identifies the Oncostatin Pathway as a Potential Key Regulator of Spinal Cord Stem Cell Fate

Robert Chevreau, Hussein Ghazale, Chantal Ripoll, Chaima Chalfouh et autres

Ependymal cells reside in the adult spinal cord and display stem cell properties in vitro. They proliferate after spinal cord injury and produce neurons in lower vertebrates but predominantly astrocytes in mammals. The mechanisms underlying this glial-biased differentiation remain ill-defined. We addressed …

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TAMI-21. TUMOR-ASSOCIATED MICROGLIA GUIDE GBM INFILTRATION VIA PLEXIN-B2

Sangjo Kang, Anirudh Sattiraju, Yuhuan Li, Shalaka Wahane et autres

Abstract Glioblastoma (GBM) is the most common malignant primary brain tumor. The nature of invasiveness of GBM makes complete surgical resection difficult. However, how GBM cells achieve wide infiltration in the brain is poorly understood. Microglia, the resident immune cells in the …

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Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer’s disease

Roland H. Friedel, Yong Huang, Minghui Wang, Shalaka Wahane et autres

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Loss-of-function manipulations to identify roles of diverse glia and stromal cells during CNS scar formation

Shalaka Wahane, Michael V. Sofroniew

Scar formation is the replacement of parenchymal cells by stromal cells and fibrotic extracellular matrix. Until as recently as 25 years ago, little was known about the major functional contributions of different neural and non-neural cell types in the formation of scar …

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Diversified transcriptional responses of myeloid and glial cells in spinal cord injury shaped by HDAC3 activity

Shalaka Wahane, Xianxiao Zhou, Xiang Zhou, Lei Ming Guo et autres

The innate immune response influences neural repair after spinal cord injury (SCI). Here, we combined myeloid-specific transcriptomics and single-cell RNA sequencing to uncover not only a common core but also temporally distinct gene programs in injury-activated microglia and macrophages (IAM). Intriguingly, we …

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