Aining Wang

Cognitive, socio-emotional and financial correlates of financial exploitation versus fraud

Pi‐Ju Liu, Stacey Wood, Aining Wang, Yaniv Hanoch et autres

Purpose Each year, millions of adults experience financial exploitation or fraud. As they are often grouped together, it remains unclear whether individuals differ in their susceptibility to financial exploitation versus fraud. The study aimed to examine factors associated with financial exploitation versus …

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Early Development of Ibuzatrelvir: Navigating Polymorph and Crystallization Challenges in a Protecting Group-Free Direct Amidation and Amidation-Dehydration Sequence

María González‐Esguevillas, Aaron F. Baldwin, Pablo J. Cabrera, Yanfei Guan et autres

Abstract Ibuzatrelvir is an orally bioavailable, next-generation clinical candidate developed for the treatment of COVID-19 infections. It was identified during the pandemic, prior to the approval of PAXLOVID, and displays a more favorable pharmacokinetic profile than nirmatrelvir. Consequently, the initial development of …

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Synthesis of Danuglipron: Development of a Scalable Alkylation and Chemoselective Hydrolysis Sequence

Ijaz Ahmed, Russell F. Algera, Aaron F. Baldwin, Andrew M. Derrick et autres

Abstract The target compound danuglipron belongs to a family of glucagon-like peptide-1 receptor agonist (GLP-1RA) candidates identified in the Pfizer laboratories for the treatment of type 2 diabetes mellitus and obesity. This article describes a development approach providing a data-centric, holistic methodology …

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Emergence of half-semiconductor behavior and tunable magnetism via carrier doping in Janus VXSe (X=Cl, Br, I) monolayers

Zhixiang Wang, Aining Wang, Z Zhenyu Ye, Yuqiao Qu et autres

Two-dimensional ferromagnetic semiconductors with high Curie temperature, large magnetic anisotropy, and electrically tunable properties are highly sought for nanoscale spintronics. Here, using first-principles calculations, we predict a new class of Janus VXSe (X=Cl, Br, I) monolayers. All three compounds are intrinsic ferromagnetic …

Emergence of half-semiconductor behavior and tunable magnetism via carrier doping in Janus VXSe (X=Cl, Br, I) monolayers

Zhixiang Wang, Aining Wang, Z Zhenyu Ye, Yuqiao Qu et autres

Two-dimensional ferromagnetic semiconductors with high Curie temperature, large magnetic anisotropy, and electrically tunable properties are highly sought for nanoscale spintronics. Here, using first-principles calculations, we predict a new class of Janus VXSe (X=Cl, Br, I) monolayers. All three compounds are intrinsic ferromagnetic …

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Rapid Development and First GMP Manufacture of AMPKγ3 Activator PF-07293893

Jocelyn L. Baer, Thomas A. Brandt, Adam R. Brown, John M. Curto et autres

We report the development and scale-up of a first-generation route to PF-07293893, an AMPKγ3 activator for the treatment of heart failure. The synthesis includes a metal-catalyzed C–N coupling, a telescoped N -Boc deprotection/amidation sequence, and a final recrystallization. Strategic process optimization addressed …

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Applications of electrical capacitance tomography in industrial systems

Benjamin J. Straiton, Shah Mahmud Hasan Chowdhury, Qussai M. Marashdeh, Fernando L. Teixeira et autres

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List of contributors

David Alumbaugh, Yong Bao, Zhang Cao, Shah Mahmud Hasan Chowdhury et autres

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Risk Factors of Financial Exploitation Versus Scam

Pi‐Ju Liu, Stacey A. Wood, Aining Wang, Yaniv Hanoch et autres

Abstract Financial exploitation (FE) perpetrators are usually seen in a position of trust, such as family members or friends, whereas perpetrators of scam tend to be unknown individuals. Few empirical studies have examined victim risk factors, and this study aimed to systematically …

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Elder Abuse Victims During the COVID-19 Pandemic: Administrative Data From San Francisco Adult Protective Services

Pi‐Ju Liu, Aining Wang, Laura M. Schwab‐Reese, Sara K. Stratton

Abstract This study examined elder mistreatment victims’ experiences at the beginning of the COVID-19 pandemic. San Francisco Adult Protective Services (APS) caseworkers conducted phone interviews to inquire about clients’ awareness of COVID-19 and unmet needs. Nine-hundred-and-thirty-four (71%) of 1,313 APS’ past clients …

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Elder Mistreatment Victims during the COVID-19 Pandemic: Administrative Data from San Francisco Adult Protective Services

Pi‐Ju Liu, Aining Wang, Laura M. Schwab‐Reese, Sara K. Stratton

Abstract This study examined elder mistreatment victims’ experiences at the beginning of the COVID-19 pandemic, focusing on their COVID-19 awareness and unmet needs. San Francisco Adult Protective Services (APS) caseworkers conducted phone interviews with clients or collaterals (client’s family, trusted other, or …

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Loneliness and Mental Health: Recommendations for Primary Care Intakes

Marissa Godfrey, Pi‐Ju Liu, Aining Wang, Stacey A. Wood

Introduction/Objectives The healthcare intake process plays a significant role in informing medical personnel about patients’ demographic information, subjective health status, and health complaints. Intake forms can help providers personalize care to assist patients in getting proper referrals and treatment. Previous studies examined …

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