Nigel Hughes

CohortDiagnostics: Phenotype evaluation across a network of observational data sources using population-level characterization

Gowtham Rao, Azza Shoaibi, Rupa Makadia, Jill H. Hardin et autres

OBJECTIVE: This paper introduces a novel framework for evaluating phenotype algorithms (PAs) using the open-source tool, Cohort Diagnostics. MATERIALS AND METHODS: The method is based on several diagnostic criteria to evaluate a patient cohort returned by a PA. Diagnostics include estimates of …

us (code pays fourni par la source)

Data sharing in neurodegenerative disease research: challenges and learnings from the innovative medicines initiative public-private partnership model

Angela C. Bradshaw, Nigel Hughes, David Vállez García, Davit Chokoshvili et autres

Efficient data sharing is hampered by an array of organizational, ethical, behavioral, and technical challenges, slowing research progress and reducing the utility of data generated by clinical research studies on neurodegenerative diseases. There is a particular need to address differences between public …

lu, be, nl, gb, de, es (code pays fourni par la source)

Clinical Characterization of Patients Diagnosed with Prostate Cancer and Undergoing Conservative Management: A PIONEER Analysis Based on Big Data

Giorgio Gandaglia, Francesco Pellegrino, Asieh Golozar, Bertrand De Meulder et autres

BACKGROUND: Conservative management is an option for prostate cancer (PCa) patients either with the objective of delaying or even avoiding curative therapy, or to wait until palliative treatment is needed. PIONEER, funded by the European Commission Innovative Medicines Initiative, aims at improving …

it, nl, us, fr, au, gb, sa, de, se, cn, be, ca, ee, gr (code pays fourni par la source)

CohortDiagnostics: phenotype evaluation across a network of observational data sources using population-level characterization

Gowtham Rao, Azza Shoaibi, Rupa Makadia, Jill H. Hardin et autres

ABSTRACT Objective This paper introduces a novel framework for evaluating phenotype algorithms (PAs) using the open-source tool, Cohort Diagnostics. Materials and Methods The method is based on several diagnostic criteria to evaluate a patient cohort returned by a PA. Diagnostics include estimates …

us (code pays fourni par la source)

Data Standards and Platform Interoperability

Nigel Hughes, Dipak Kalra

be (code pays fourni par la source)

Evaluating a novel approach to stimulate open science collaborations: a case series of “study-a-thon” events within the OHDSI and European IMI communities

Nigel Hughes, Peter R. Rijnbeek, Kees van Bochove, Talita Duarte‐Salles et autres

Objective: We introduce and review the concept of a study-a-thon as a catalyst for open science in medicine, utilizing harmonized real world, observation health data, tools, skills, and methods to conduct network studies, generating insights for those wishing to use study-a-thons for …

be, nl, es, gb, us (code pays fourni par la source)

A concentric circles view of health data relations facilitates understanding of sociotechnical challenges for learning health systems and the role of federated data networks

Richard Milne, Mark D. Sheehan, Brendan Barnes, Janek Kapper et autres

The ability to use clinical and research data at scale is central to hopes for data-driven medicine. However, in using such data researchers often encounter hurdles–both technical, such as differing data security requirements, and social, such as the terms of informed consent, …

gb, be, ee, us (code pays fourni par la source)

European Health Data Space—An Opportunity Now to Grasp the Future of Data-Driven Healthcare

Denis Horgan, Marián Hajdúch, Marilena Vrana, Jeannette Soderberg et autres

The May 2022 proposal from the European commission for a 'European health data space' envisages advantages for health from exploiting the growing mass of health data in Europe. However, key stakeholders have identified aspects that demand clarification to ensure success. Data will …

in, cz, be, gb, nl, it, fr (code pays fourni par la source)

EHDEN - D6.3 - Analysis PPP exploitation models

Carlos Alcibiades Gimenez Diaz, Montse Camprubi, Inari Soininen, Johann Proeve et autres

This deliverable reports on the study of potential exploitation models relevant to public-private partnerships, analysing previous successful and unsuccessful experiences from other IMI projects and beyond. These will serve as starting points and, potentially, one or more “blueprints” for EHDEN sustainability could …

us, be, br (code pays fourni par la source)

EHDEN - D6.8 - Report on liaison with other BD4BO projects

Carlos Díaz, Nigel Hughes, Montse Camprubi

IMI’s Big Data for Better Outcomes (BD4BO) programme was designed to facilitate the use of “big data” to enable the transition towards value-based, outcomes-focused healthcare systems in Europe through the participation of several projects. Within task 6.7, EHDEN has been the entry …

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Using the Data Quality Dashboard to Improve the EHDEN Network

Clair Blacketer, Erica A. Voss, Frank DeFalco, Nigel Hughes et autres

Federated networks of observational health databases have the potential to be a rich resource to inform clinical practice and regulatory decision making. However, the lack of standard data quality processes makes it difficult to know if these data are research ready. The …

nl, us (code pays fourni par la source)

Using the Data Quality Dashboard to Improve the EHDEN Network

Clair Blacketer, Erica A. Voss, Frank DeFalco, Nigel Hughes et autres

Background: Observational health data has the potential to be a rich resource to inform clinical practice and regulatory decision making. However, the lack of standard data quality processes makes it difficult to know if these data are research ready. The EHDEN COVID-19 …

nl, us (code pays fourni par la source)