Aldo Roberto Boccaccini

Cerium-Doped Cotton-like Bioactive Glass Nanofibers Enhance Bone Regeneration through Regulatory T Cell-Associated Osteoimmunomodulation

Kaixiao Xue, Bowen Cai, Meng Li, Zhi Shen et autres

Abstract The immune milieu formed after bone injury critically affects subsequent repair, yet biomaterial-based regulation of regulatory T cells (Tregs) remains less explored than macrophage-centered immunomodulation. Here, cotton-like cerium-doped bioactive glass nanofibers (Ce-BGFs) were fabricated by sol-gel electrospinning to investigate Treg-related osteoimmune …

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Antioxidant‐Thermoresponsive Collagen/Chitosan Nanocomposite Hydrogels With Praseodymium‐Doped Mesoporous Bioglass for Enhanced Bone Regeneration

Kulwinder Kaur, Zhiyan Xu, Aldo Roberto Boccaccini, Ciara M. Murphy

ABSTRACT Oxidative stress is a critical barrier to effective bone regeneration, often impairing cellular function and osteogenic differentiation. In this study, we report the novel development of a multifunctional chitosan/collagen (CS/Coll) hydrogel integrated with praseodymium‐doped mesoporous bioactive glass nanoparticles (Pr‐MBGNs) engineered for …

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Mesoporous Bioactive Glass Nanoparticles Doped with Sr2+ and Cu2+: In Vitro Apatite Mineralization and Biocompatibility

Ana P.N. Alves, Meng Li, Marcela Arango‐Ospina, Ana Maria Beltrán et autres

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Use of manuka honey and oregano essential oil as antibacterial coatings for 3D-printed alginate/PVA/45S5 bioactive glass scaffolds

Vivian Inês dos Santos, Meng Li, Sara Benhassan, Dachamir Hotza et autres

The treatment of infected bone defects remains a major clinical challenge due to the limitations of conventional systemic antibiotic therapies and the ability of bacteria to form resilient biofilms. In this context, scaffolds capable of delivering local antibacterial activity while supporting tissue …

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Electrophoretic Deposition and Characterization of Multicomponent Chitosan/Eudragit or Poly(4-vinylpyridine) Coatings Incorporating Mesoporous Bioactive Glass and Silver Nanoparticles on Ti-13Nb-13Zr Alloy

Łukasz Pawłowski, Yixin Liu, Chen-Ying Su, Aleksandra Mirowska et autres

In this study, multifunctional composite coatings based on chitosan (CS), mesoporous bioactive glass nanoparticles (MBGNPs), and silver nanoparticles (AgNPs) were successfully deposited on Ti-13Nb-13Zr alloy by electrophoretic deposition (EPD). Two coating systems containing Eudragit E100 (EE100) or poly(4-vinylpyridine) (P4VP) were developed to …

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High‐Performance Bio‐Glue From the Berries of a Parasitic Plant

Ufuk Gürer, Jana T. Reh, Jonas Röder, Umut Günsel et autres

Most commercial adhesives are still petroleum-based. Despite extensive efforts to develop sustainable alternatives, bio-based adhesives often require chemical modification of their components, or they fail to achieve rapid, high-performance bonding. Here, we report a fully bio-based adhesive derived primarily from a (poly)saccharide …

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Multifunctional Wound Dressings: Melt Electrowritten Scaffolds Combined With Phytotherapeutic Composite Hydrogels

Andrada‐Ioana Damian‐Buda, Aldo Roberto Boccaccini, Irem Unalan

ABSTRACT The increasing prevalence of impaired wounds, caused mainly by diabetes or aging, alongside the growing number of bacterial infections, indicates the need for alternative tissue engineering solutions. In this study, we developed novel melt electrowritten (MEW) polycaprolactone (PCL) scaffolds incorporated with …

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An Ion‐Based Strategy Toward Synergistic Surface Functionalization Combining the Osteogenic Properties and NIR‐Mediated Antibacterial Activity of PEEK

Zhiyan Xu, Ondřej Adam, Marek Doubrava, Ana M. Beltrán et autres

Persistent implant-associated infections critically compromise the longevity and success of orthopedic prostheses. Herein, we present a facile surface-engineering strategy to construct a multifunctional PEEK-based implant by introducing manganese-chelated polydopamine (Mn@p) and mesoporous bioactive glass nanoparticles (MBGNs) onto sulfonated PEEK (SPEEK). The resulting …

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PIEZO1 upregulation in spinal cord astrocytes during MOG 35-55 -induced EAE correlates with ECM remodeling

Maik Hintze, Rittika Chunder, Michael Schwarz, Zafar Nurmatov et autres

Abstract Background Extracellular matrix (ECM) remodeling is increasingly recognized as an important component of neuroinflammatory pathology in multiple sclerosis (MS), yet the mechanisms by which CNS cells sense and respond to alterations in their mechanical environment and the spatial across which mechanical …

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Tensile Stimulation in Biorelevant Culture Conditions Enhances MSC and TPSC Tenogenesis on Aligned Electrospun Scaffolds

Vera Citro, Aldo Roberto Boccaccini, Nicholas Robert Forsyth, Tina Patricia Dale

Tendon injuries affect millions each year, yet effective repair remains limited by the tissue's avascular nature and complex mechanobiology. An anisotropic electrospun scaffold functionalized with GDF‐7‐loaded mesoporous silica nanoparticles (MSNs) is developed to address these challenges. GDF‐7 is efficiently encapsulated (99.9%) in …

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Fiber-Reinforced Hydrogel Constructs Based on Melt Electrowritten Scaffolds for Osteochondral Tissue Engineering

Carla Maximiliane Niendorf, Phillip Barkow, Janine Waletzko‐Hellwig, Vivica Freiin Grote et autres

Due to the limited intrinsic regenerative capacity of chondrocytes, osteochondral defects caused by trauma or ageing often lead to the rise of osteoarthritis (OA). Articular cartilage plays an important role in load-bearing joints during physical movements. It can be considered as a …

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Fabrication and Characterization of Optically Translucent Glass Matrix Composites

Peer Fehling, Dagmar Hülsenberg, H. Kern, Dagmar Raab et autres

Besides the well-known requirement of matching thermomechanical properties of fibre and matrix in composite materials to realize effective reinforcement mechanisms, in the present composites also the refractive index of fibre and matrix must be matched to achieve optical translucency. Moreover the optimisation …

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