Marta Venturas

A 3-DIMENSIONAL IN SITU RNA TRANSCRIPTOME ATLAS OF HUMAN PREIMPLANTATION EMBRYOS

Ehsan Habibi, Goli Ardestani, Marta Venturas, Denny Sakkas

us (code pays fourni par la source)

Capturing aberrant cell behaviors producing defects in human embryos via live imaging

Hiroki Akizawa, Ana Domingo-Muelas, Maria Pardo‐Figuerez, Blake Hernandez et autres

The generation of human embryos in vitro has revolutionized reproductive medicine, and also made it possible to study fundamental aspects of early human development. However, human preimplantation embryos often display an array of morphological defects associated with poor development and implantation. Here, …

us, es (code pays fourni par la source)

The Future of the IVF Laboratory

Goli Ardestani, Marta Venturas, Denis A. Vaughan, Denny Sakkas

In the first reported case of in vitro fertilization and embryo development in the human, Rock and Menkin [ 1 ] made the following description in 1944 about the culture and development of a fertilized embryo: “The eggs were incubated in serum …

O-123 Ultrafast versus conventional blastocyst warming: equivalent developmental outcomes following the extended in vitro culture of 221 embryos beyond the implantation stages

Marta Venturas, Goli Ardestani, M J Zamora, Fernando Azpiroz et autres

Abstract Study question Does one-step ultrafast warming affect the viability and development outcomes of human blastocysts cultured up to 10 days post-fertilization (D10)? Summary answer The one-step ultrafast protocol is as effective as conventional multi-step blastocyst warming in terms of survival and …

us, es (code pays fourni par la source)

THE ROLE OF PYRUVATE IN IMPROVING MATURATION RATES AFTER RESCUE IN VITRO MATURATION OF GERMINAL VESICLE STAGE OOCYTES

Goli Ardestani, Marta Venturas, Júlia Artigas Espuny, Elisa Marozzi Cruz et autres

Metabolic imaging of human cumulus cells reveals associations with pregnancy and live birth

Marta Venturas, Catherine Racowsky, Daniel J. Needleman

STUDY QUESTION: Can fluorescence lifetime imaging microscopy (FLIM) detect associations between the metabolic state of cumulus cell (CC) samples and the clinical outcome of the corresponding embryos? SUMMARY ANSWER: FLIM can detect significant variations in the metabolism of CC associated with the …

us, fr (code pays fourni par la source)

BlastAssist: a deep learning pipeline to measure interpretable features of human embryos

Helen Y Yang, Brian Leahy, Won-Dong Jang, Donglai Wei et autres

STUDY QUESTION: Can the BlastAssist deep learning pipeline perform comparably to or outperform human experts and embryologists at measuring interpretable, clinically relevant features of human embryos in IVF? SUMMARY ANSWER: The BlastAssist pipeline can measure a comprehensive set of interpretable features of …

us, il (code pays fourni par la source)

P-175 Human cumulus cell telomere length and its association with assisted reproduction outcomes

Kishlay Kumar, L Nesbeth, Marta Venturas, Daniel J. Needleman et autres

Abstract Study question Is there any relationship between the relative telomere length (RTL) within cumulus cells (CCs) and the outcome of assisted reproductive treatment using the corresponding oocyte? Summary answer Lower RTLs in CCs were significantly associated with embryos chosen for transfer …

us, fr (code pays fourni par la source)

Noninvasive metabolic profiling of cumulus cells, oocytes, and embryos via fluorescence lifetime imaging microscopy: a mini-review

Marta Venturas, Xingbo Yang, Denny Sakkas, Dan Needleman

A major challenge in ART is to select high-quality oocytes and embryos. The metabolism of oocytes and embryos has long been linked to their viability, suggesting the potential utility of metabolic measurements to aid in selection. Here, we review recent work on …

us, de (code pays fourni par la source)

Fluorescence lifetime imaging microscopy (FLIM) detects differences in metabolic signatures between euploid and aneuploid human blastocysts

Jaimin S. Shah, Marta Venturas, Tim H. Sanchez, Alan S. Penzias et autres

STUDY QUESTION: Can non-invasive imaging with fluorescence lifetime imaging microscopy (FLIM) detect metabolic differences in euploid versus aneuploid human blastocysts? SUMMARY ANSWER: FLIM has identified significant metabolic differences between euploid and aneuploid blastocysts. WHAT IS KNOWN ALREADY: Prior studies have demonstrated that …

us, es (code pays fourni par la source)

Metabolic state of human blastocysts measured by fluorescence lifetime imaging microscopy

Marta Venturas, Jaimin S. Shah, Xingbo Yang, Tim H. Sanchez et autres

STUDY QUESTION: Can non-invasive metabolic imaging via fluorescence lifetime imaging microscopy (FLIM) detect variations in metabolic profiles between discarded human blastocysts? SUMMARY ANSWER: FLIM revealed extensive variations in the metabolic state of discarded human blastocysts associated with blastocyst development over 36 h, …

es, us (code pays fourni par la source)

Extensive analysis of mitochondrial DNA quantity and sequence variation in human cumulus cells and assisted reproduction outcomes

Kishlay Kumar, Marta Venturas, Daniel J. Needleman, Catherine Racowsky et autres

STUDY QUESTION: Are relative mitochondrial DNA (mtDNA) content and mitochondrial genome (mtGenome) variants in human cumulus cells (CCs) associated with oocyte reproductive potential and assisted reproductive technology (ART) outcomes? SUMMARY ANSWER: Neither the CC mtDNA quantity nor the presence of specific mtDNA …

gb, us, fr (code pays fourni par la source)