Tongkai Chen

Rationally Designed Microneedles that Remodel the Follicular Microenvironment for Androgenetic Alopecia Therapy

Hongyan Dong, Weisen Lin, Yijie Yuan, Lingfu Zeng et autres

Abstract Androgenetic alopecia (AGA) is a systems-level disorder driven by converging metabolic, signaling, oxidative, vascular, and inflammatory alterations within hair follicles and their niches. Current single-target therapies exhibit limited efficacy due to poor penetration across the scalp’s dual barriers. Although chemical and …

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Helicobacter pylori Induce Col1a1 Up-Regulation, DNA Damage, and Fibrosis in Gastric Precancerous Lesions

Siyi Li, Changhua Liu, Qiuyue Li, Penghui Yang et autres

Abstract Helicobacter pylori (H. pylori) induces gastric precancerous lesions (GPL), but their underlying biomarkers remain poorly characterized. To establish a GPL model, BALB/c mice were inoculated with H. pylori via gavage. Immunofluorescence confirmed successful modeling by detecting H. pylori distribution and aberrant …

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Differential gut microbiota modulation associated with anti-Parkinsonian effects of Ophiopogon japonicus across geographical origins and extraction methods

Sijia Gao, Zixuan Wang, Ai-Hua Xie, Jia-Xin Wu et autres

Introduction Ophiopogon japonicus (OJ) is a medicine-food homologous plant widely consumed in East Asia and has attracted attention for its potential anti-Parkinsonian properties. However, the influence of geographical origin and extraction methods on its bioactive profile, gut microbiota modulation, and anti-Parkinsonian effects …

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Natural hydrogel for the synergistic topical therapy of androgenetic alopecia

Yanhua Han, Weisen Lin, Yijie Yuan, Xiaoyu Qin et autres

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Ultrathin 2D Boron Nanosheets Delivering Matrine for Enhanced Photodynamic Therapy against Hypoxic Tumors

Yuying Zhao, Pi Liu, Taojian Fan, R Y et autres

Targeting mitochondrial quality control: Ginsenoside Rg1 as a therapeutic candidate for neuromuscular diseases

Xiaoqing Cai, Haixia Wang Lan, Yingying Jiao, Yaoqi Wu et autres

Neuromuscular diseases (NMDs) are complex disorders caused by the dysfunction of motor neurons and skeletal muscles. They lead to progressive muscle weakness and atrophy and impose a significant economic burden on patients and society at large. The dysregulation of mitochondrial quality control …

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Biomimetic nanodelivery system with simultaneous blood–brain barrier-crossing and neuroprotective abilities for anti-parkinsonian therapy

Jinmei Qiu, Guowang Cheng, Jiaxin Wu, Chen Wang et autres

BACKGROUND: Parkinson's disease (PD) has emerged as a critical public health challenge amidst global population aging. The pathogenesis of PD is extremely complex. Notably, evidence showed that neuroinflammation due to microglial activation is a critical driver of dopaminergic neuron loss in patients …

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A customized immunomodulator reinforces the T cell-mediated immunological cascade for cancer therapy

Guowang Cheng, Jiaxin Wu, Wei Liu, Hao Cui et autres

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Universal Albumin Drugs‐Cored Spherical Nucleic Acid (ad‐SNA) Platform for Targeted Drug Delivery

Xuan Wang, Yuqing Li, Weiwei Yao, Jiawei Zhu et autres

Albumin-based drug delivery system, exemplified by FDA-approved treatments like Abraxane, have demonstrated significant potential in cancer therapy. However, albumin carriers still suffer from poor tumor-targeting capability, leading to low efficacy and systemic side effects on healthy cells in applications. Here, we report …

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Universal Albumin Drugs‐Cored Spherical Nucleic Acid (ad‐SNA) Platform for Targeted Drug Delivery

Xuan Wang, Yuqing Li, Weiwei Yao, Jiawei Zhu et autres

Abstract Albumin‐based drug delivery system, exemplified by FDA‐approved treatments like Abraxane, have demonstrated significant potential in cancer therapy. However, albumin carriers still suffer from poor tumor‐targeting capability, leading to low efficacy and systemic side effects on healthy cells in applications. Here, we …

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Microneedle-Based Approaches for Skin Disease Treatment

Yanhua Han, Xiaoyu Qin, Weisen Lin, Chen Wang et autres

The use of microneedles (MNs) has been established as an effective transdermal drug delivery strategy that has been extensively deployed for treating various diseases, including skin diseases. MNs can surpass the constraints of conventional drug delivery methods by their superior safety and …

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Design, current states, and challenges of nanomaterials in anti-neuroinflammation: A perspective on Alzheimer’s disease

Xinyang Hong, Tongkai Chen, Yunyun Liu, Jun Li et autres

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