Dong‐Yan Shen

Correction: Positive feedback loop of IL-1β/Akt/RARα/Akt signaling mediates oncogenic property of RARα in gastric carcinoma

Hong‐Yue Ren, Fan Liu, Guili Huang, Yu Liu et autres

IL6/STAT3 induced GRWD1 mediates aerobic glycolysis via P53/GLUT1 signal axis in colon carcinoma

Jin Shang, Hong‐Yue Ren, Donghua Liu, Shihang Tang et autres

GRWD1, a novel WD40-repeat-containing protein designated glutamate-rich WD repeat, is highly expressed in CRC and participates in a series of oncogenic activities. However, the cause of GRWD1 overexpression and its oncogenic mechanism in CRC remains elusive. This study revealed that GRWD1 was …

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Infective aortitis caused by Corynebacterium striatum in a patient with twice orthotopic heart transplantation

Wei Xiang, Lingyun Kong, Peng Zou, Dong‐Yan Shen et autres

BACKGROUND: Infective aortitis (IA) with vegetation formation is a rare but potentially life-threatening complication in patients with heart transplantation (HTx). IA caused by Corynebacterium striatum (C. striatum) has scarcely been reported. Herein, we present a case of IA caused by C. striatum …

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RBM39 Functions as a Potential Oncogene Through the NF-κB Signaling Pathway in Colorectal Cancer Cells

Yatao Wang, YaTao Wang, Zhenjie Yang, Zhangquan Yang et autres

Colorectal cancer (CRC) ranks as the third most frequently diagnosed cancer and is the second leading cause of cancer-related deaths globally.Recently, RNA-binding protein 39(RBM39), a critical factor in tumor-targeted mRNA and protein expression, has played a vital role in tumorigenesis and has …

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Analysis of the efficacy of the external fenestrated endovascular repair for Stanford type B aortic dissection with aberrant right subclavian artery

Hao Zhao, Yongqiang Yue, Dong‐Yan Shen, Qingquan Liu et autres

Objective: To explore the early and mid-term efficacy of thoracic endovascular repair (TEVAR) for the treatment of Stanford type B aortic dissection (AD) complicated by aberrant right subclavian artery (ARSA). Methods:We conducted a retrospective analysis of clinical and follow-up data for 16 …

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A metal–phenolic nanotuner induces cancer pyroptosis for sono-immunotherapy

Guohao Wang, Dongmei Wang, Huimin Tian, Lu Xia et autres

GSDME cleavage. In an orthotopic breast cancer model, HTA enhanced anti-tumor immunity and improved the efficacy of sonodynamic therapy (SDT). This approach presents a novel strategy for augmenting SDT through epigenetically induced pyroptosis.

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Correction to: miR‑9‑5p Suppresses Malignant Biological Behaviors of Human Gastric Cancer Cells by Negative Regulation of TNFAIP8L3

Yanyun Fan, Ying Shi, Zhenhe Lin, Xiaoxiao Huang et autres

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Modulation of lipid profile by secretory phospholipase A2 group IIA: Verification with a transgenic mouse model

Ling Liang, Jing Song, Shisheng Miao, Qiang Xie et autres

We previously demonstrated a positive relation of secretory phospholipase A2 group IIA (sPLA2-IIA) with circulating high-density lipoprotein cholesterol (HDL-C) in patients with coronary artery disease , and sPLA2-IIA increased cholesterol efflux in THP-1 cells through peroxisome proliferator-activated receptor-γ (PPAR-γ)/liver X receptor α/ATP-binding …

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KHDRBS1 as a novel prognostic signaling biomarker influencing hepatocellular carcinoma cell proliferation, migration, immune microenvironment, and drug sensitivity

Rui Fan, Fahui Liu, Qiming Gong, Donghua Liu et autres

Background: Human tumors pose significant challenges, with targeted therapy against specific molecular targets or signaling pathways being a mainstay alongside surgical resection. Previous studies have implicated KHDRBS1 in the oncogenesis of certain human tumors such as colorectal and prostate cancers, underscoring its …

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Trilobolide-6-O-isobutyrate exerts anti-tumor effects on cholangiocarcinoma cells through inhibiting JAK/STAT3 signaling pathway

Haoxuan Zhang, Rui Fan, Qian-En Chen, Linjun Zhang et autres

Trilobolide-6-O-isobutyrate exhibits significant antitumor effects on cholangiocarcinoma (CCA) cells by effectively inhibiting the JAK/STAT3 signaling pathway. This study aims to investigate the mechanisms underlying the antitumor properties of trilobolide-6-O-isobutyrate, and to explore its potential as a therapeutic agent for CCA. This study …

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Downregulation of dermatopontin in cholangiocarcinoma cells suppresses CCL19 secretion of macrophages and immune infiltration

Peng Xu, Siyang Li, Ke Liu, Rui Fan et autres

OBJECTIVE: The tumor microenvironment (TME) in cholangiocarcinoma (CHOL) is typically characterized by a low level of immune infiltration, which accounts for the dismal prognosis of this patient population. This study sought to investigate the mechanisms underlying the reduced infiltration of immune cells …

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DPY30 knockdown suppresses colorectal carcinoma progression via inducing Raf1/MST2-mediated apoptosis

Haifeng Jiang, Wei-Chao Su, HaiXing Wang, Chunying Luo et autres

Colorectal Carcinoma (CRC) is one of the most common malignant tumors of the digestive tract, with a high mortality rate. DPY30 is one of the core subunits of the histone methyltransferase complex, which was involved in many cancer processes. However, the role …

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