Yi Zuo

Data from: 5-HT2ARs in layer 5 pyramidal neurons mediate the neuroplastic but not the hallucinogenic effects of psilocybin

Jacob J. Baker, Emily Kogan, Shaorong Ma, Ju Lu et autres

This data was collected to investigate the role of serotonin 2A receptors (5-HT2ARs) expressed in cortical layer 5 pyramidal neurons (L5 PyrNs) in psilocybin-induced hallucination-like behavior and synaptic neuroplasticity in mice. The dataset contains head-twitch response (HTR) counts recorded after psilocybin or …

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Adolescent social isolation induces persistent impairments in emotional discrimination and helping behavior

Hyo Gun Lee, Ju Lu, Yi Zuo

Prosocial behaviors, helpful actions directed toward the well-being of others, are an essential component of social behavior. Adolescence is a particularly sensitive period for the development of social behaviors, yet how social experience during this window shapes prosocial behavior remains poorly understood. …

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Targeting insulo-frontal pathway to reduce stress-evoked cognitive rigidity

Yi Zuo, Shaorong Ma, Kuan Hong Wang

Cognitive rigidity often follows chronic stress and is prevalent in stress-related psychiatric disorders, yet the underlying neural circuit mechanisms remain unclear. Using attentional set-shifting tasks (AST) in mice, we identified projection from the anterior insular cortex to the medial prefrontal cortex (aIC→mPFC) …

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Dissociating the Hallucinogenic and Neuroplastic Effects of Psilocybin

Jacob J. Baker, Emily Kogan, Shaorong Ma, Ju Ming Lu et autres

Abstract It is unclear how serotonin 2A receptors (5-HT 2A Rs) in cortical layer 5 pyramidal neurons (L5 PyrNs) differentially contribute to psilocybin-induced hallucinations versus neuroplasticity. Here we show that psilocybin promotes synapse formation and maturation while accelerating the elimination of pre-existing …

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Experimental investigation of the fatigue performance of Ti-6Al-4V titanium alloy subjected to shot peening

Xiao Zhang, Yi Zuo, Zhuotao Fan

Abstract This work systematically investigates the fatigue behavior of Ti-6Al-4V titanium alloy plates subjected to shot peening under five different intensity levels. Fatigue tests were conducted, and the detailed fatigue rating (DFR) was calculated to quantify fatigue improvement. The results show that …

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A dynamic enhanced electrical stimulation system coordinates non-neural cells via single-input cues for neuro-vascularized bone regeneration

Jiajing Tang, Yinglong Zhang, Qing Fu Zhao, Weihu Yang et autres

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Intranasal delivery of hypoxia-preconditioned extracellular vesicles derived from BMSCs alleviates neuroinflammation and brain dysfunction in TBI

Li Chen, Yang Yang, Junwei Chen, Yinghong Lin et autres

Traumatic brain injury (TBI) leads to secondary injuries, such as neuroinflammation and brain dysfunction, which is a critical challenge in clinical treatment. The use of bone marrow mesenchymal stem cells (BMSCs) is one of the potential strategies to treat TBI by alleviating …

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Persistent cortical excitatory neuron dysregulation in adult Chd8 haploinsufficient mice

Alex S. Nord, César P. Canales, Stephanie A. Lozano, Nicholas A. Frost et autres

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The effect of shot peening on the fatigue performance of the R-region in 2024-T351 machined components

Yi Zuo, Xianchao Li, Tong Wang

Abstract To investigate the effect of shot peening on the fatigue performance of the R-region in 2024-T351 machined components, a specially designed test specimen was created. It can cause fatigue cracks to initiate in the R-region. The R-region of the specimen was …

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Cross-Species Framework for Emotional Well-Being and Brain Aging

Janine M. Simmons, Adam G. Turnbull, Yi Zuo, Yeates Conwell et autres

Importance: Emotional well-being (EWB) is an emerging therapeutic target for managing and preventing symptoms associated with Alzheimer disease and related dementias (ADRD). However, more research is needed to establish causal inferences between brain changes, EWB, and behavioral changes observed in typical aging …

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The Role of Music Therapy in Enhancing Social, Emotional, and Cognitive Development in Children with Autism Spectrum Disorder

Yi Zuo

Music therapy has emerged as a promising intervention for enhancing the emotional regulation and social reciprocity of children with Autism Spectrum Disorder (ASD), their cognitive development, and fostering good relations between them and their parents. ASD has an impact on social interaction, …

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Wailing Barbarians and Bloody Tears: Affect and Self-other Imagination in Medieval Eastern Eurasia

Yi Zuo

A rich body of records from across medieval Eurasia documents a funerary practice among the steppe nomads: Mourners wailed and lacerated their faces, releasing blood-stained tears to commemorate the dead. Over time, as the act grew independent from a funerary context, it …

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