Oliver Stiedl

Editorial: Home cage-based phenotyping in rodents: innovation, standardization, reproducibility, and translational improvement, volume II

Lars Lewejohann, Oliver Stiedl, Stefano Gaburro, Silvia Mandillo

the biology of the species in question. In fact, it has repeatedly been shown that HCM is not limited to small, minimally stimulating enclosures. Its full potential can likewise be exploited in more complex enclosures, right up to semi-natural environments in which …

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Protein instability, haploinsufficiency, and cortical hyper-excitability underlie STXBP1 encephalopathy

Susanne Schoch, James J. Crowley, Désireé Schut, Oliver Stiedl et autres

De novo heterozygous mutations in STXBP1/Munc18-1 cause early infantile epileptic encephalopathies (EIEE4, OMIM #612164) characterized by infantile epilepsy, developmental delay, intellectual disability, and can include autistic features. We characterized the cellular deficits for an allelic series of seven STXBP1 mutations and developed …

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Challenges and expectations on the use of automated home cage monitoring for advancing laboratory animal care and welfare

Jordi L. Tremoleda, Aurora Brønstad, Heidrun Potschka, Petra Seebeck et autres

COST Action TEATIME unites experts to advance automated monitoring technologies for laboratory animals, with a focus on Home Cage Monitoring (HCM) systems. The use of HCM has great potential to revolutionise welfare monitoring by enabling continuous, non-invasive tracking of physiological and behavioural …

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Enhancing Animal Welfare Through Home Cage Monitoring Systems

Heidrun Potschka, Francisco Drusso Martínez-García, Miriam Van Der Meulen, Jan‐Bas Prins et autres

Abstract Home cage monitoring (HCM) is increasingly being used in scientific studies but its application in the field of animal welfare is lagging. Advances in animal research are predominantly driven by scientific projects whose primary goal is increasing scientific knowledge but not …

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Differences in baseline and dynamic plasma/saliva endocrine and linear/non-linear heart measures between patients with major depression and closely-matched healthy subjects: A 3-day combined overnight dexamethasone/metyrapone challenge study

Agorastos Agorastos, Oliver Stiedl, Alexandra Heinig, Anne Sommer et autres

BACKGROUND: Major depressive disorder (MDD) has been consistently associated with hypothalamic-pituitary-adrenal (HPA)-axis and autonomic nervous system (ANS) (re-)activity abnormalities, however, often with conflicting results. METHODS: This study offers a concurrent multi-measure assessment of both HPA-axis and ANS activity and reactivity over 3 …

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Identifying Cardiovascular Risk by Nonlinear Heart Rate Dynamics Analysis: Translational Biomarker from Mice to Humans

Torben Hager, Agorastos Agorastos, Sven Ove Ögren, Oliver Stiedl

BACKGROUND: The beat-by-beat fluctuation of heart rate (HR) in its temporal sequence (HR dynamics) provides information on HR regulation by the autonomic nervous system (ANS) and its dysregulation in pathological states. Commonly, linear analyses of HR and its variability (HRV) are used …

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Continuous locomotor activity monitoring to assess animal welfare following intracranial surgery in mice

Mazyar Abdollahi Nejat, Oliver Stiedl, August Benjamin Smit, Ronald E. van Kesteren

Locomotor activity can serve as a readout to identify discomfort and pain. Therefore, monitoring locomotor activity following interventions that induce potential discomfort may serve as a reliable method for evaluating animal health, complementing conventional methods such as body weight measurement. In this …

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Heart Rate Variability as a Translational Dynamic Biomarker of Altered Autonomic Function in Health and Psychiatric Disease

Agorastos Agorastos, Alessandra Chiara Mansueto, Torben Hager, Eleni Pappi et autres

The autonomic nervous system (ANS) is responsible for the precise regulation of tissue functions and organs and, thus, is crucial for optimal stress reactivity, adaptive responses and health in basic and challenged states (survival). The fine-tuning of central ANS activity relies on …

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Editorial: Home Cage-Based Phenotyping in Rodents: Innovation, Standardization, Reproducibility and Translational Improvement

Stefano Gaburro, York Winter, Maarten J. A. Loos, Jeansok John Kim et autres

EDITORIAL article Front. Neurosci., 23 June 2022Sec. Sleep and Circadian Rhythms https://doi.org/10.3389/fnins.2022.894193

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Longitudinal Assessment of Working Memory Performance in the APPswe/PSEN1dE9 Mouse Model of Alzheimer’s Disease Using an Automated Figure-8-Maze

Fran C. van Heusden, Sara Palacín i Bonsón, Oliver Stiedl, August Benjamin Smit et autres

Alzheimer's disease (AD) is a progressive neurodegenerative disorder, with a long preclinical and prodromal phase. To enable the study of disease mechanisms, AD has been modeled in many transgenic animal lines and cognitive functioning has been tested using several widely used behavioral …

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Applications of Implantable Radio Telemetry in Small Laboratory Animals

Klaas Kramer, Steve Hachtman, Michael Girand, Oliver Stiedl

Radio telemetry is the gold standard for obtaining physiological measurements from awake and freely moving laboratory animals without stress-induced alterations that confound the results. Implantable telemetry for laboratory animal research applications is the net result of innovative advances in biomaterials, leads, catheters, …

Injection of galanin into the dorsal hippocampus impairs emotional memory independent of 5-HT1A receptor activation

Oliver Stiedl, Eugenia Kuteeva, Tomas G. M. Hökfelt, Sven Ove Ögren

There is evidence that interaction between the neuropeptide galanin and the 5-HT1A receptor represents an integrative mechanism in the regulation of serotonergic neurotransmission. Thus, in rats intracerebroventricular (i.c.v.) galanin did not impair retention in the passive avoidance (PA) test 24 h after …

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