Jenny K. Koo

Early echocardiographic markers following deferred cord clamping with high or low oxygen in extremely low gestation infants (DOXIE–Echo)

Jenny K. Koo, Nohemi Torres, Satyan Lakshminrusimha, Anup C. Katheria

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Expectant Management vs Medication for Patent Ductus Arteriosus in Preterm Infants

M Bethany Ball, Laurie A. Hogden, Kyle Binion, Erick B. Gerday et autres

Importance: The management of patent ductus arteriosus (PDA) in preterm infants is controversial. Objective: To determine whether expectant management compared with active treatment of a protocol-defined PDA in preterm infants decreases the incidence of death or bronchopulmonary dysplasia (BPD). Design, Setting, and …

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Expectant Management vs Medication for Patent Ductus Arteriosus in Preterm Infants

Matthew Maxwell Laughon, Sonia Thomas, Kristi L. Watterberg, Kathleen A. Kennedy et autres

Importance: The management of patent ductus arteriosus (PDA) in preterm infants is controversial. Objective: To determine whether expectant management compared with active treatment of a protocol-defined PDA in preterm infants decreases the incidence of death or bronchopulmonary dysplasia (BPD). Design, Setting, and …

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Antenatal Prediction of Early Cord Clamping among Infants Born Extremely Preterm

Anup C. Katheria, Rebecca A. Dorner, William A. Grobman, Matthew A. Rysavy et autres

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Early Intratracheal Budesonide to Reduce Bronchopulmonary Dysplasia in Extremely Preterm Infants

Namasivayam Ambalavanan, Waldemar A. Carlo, Kayla J. Nowak, Laura Elizabeth Wiener et autres

Importance: Extremely preterm infants are at high risk for bronchopulmonary dysplasia (BPD) and death. Multiple small randomized clinical trials showed that a combination of budesonide with surfactant compared with surfactant alone reduced BPD or death. Objective: To determine if early intratracheal administration …

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Deferred Cord Clamping With High Oxygen in Extremely Preterm Infants

Anup C. Katheria, Felix Ines, Henry Lee, Christina A. Sollinger et autres

Importance: Deferred cord clamping (DCC) with high oxygen may reduce early hypoxia in preterm newborns. However, the safety and efficacy of this procedure has never been studied. Objective: To determine whether providing 100% oxygen by face mask during the window of DCC …

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Chest Compression Superimposed with Sustained Inflation or 3:1 Compression/Ventilation Ratio During Neonatal Cardiopulmonary Resuscitation in the Delivery Room: A Systematic Review and Meta-Analysis

Jenny K. Koo, Anup C. Katheria, Brenda Hiu Yan Law, Anne Lee Solevåg et autres

Background: Current resuscitation guidelines recommend a 3:1 chest compression/ventilation (C:V) ratio, which is associated with high morbidity and mortality. An alternative might be continuous chest compression superimposed with high distending pressure or sustained inflation (CC + SI). Objective: To compare CC + …

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How to Use POCUS to Place Umbilical Lines

Jenny K. Koo

Umbilical arterial catheters (UACs) and umbilical venous catheters (UVCs) are the most commonly used central lines in the NICU and serve as the primary vascular access in critically ill newborns for the first 1 to 2 weeks after birth. (1)(2) Confirmation that …

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Selective early medical treatment of the patent ductus arteriosus in extremely low gestational age infants: a pilot randomised controlled trial protocol (SMART-PDA)

Souvik Mitra, Audrey Hébert, Michael P. Castaldo, Tim Disher et autres

Introduction Patent ductus arteriosus (PDA) is the most common cardiovascular problem that develops in extremely preterm infants and is associated with poor clinical outcomes. Uncertainty exists on whether early pharmacotherapeutic treatment of a clinically symptomatic and echocardiography-confirmed haemodynamically significant PDA in extremely …

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Chest compressions superimposed with sustained inflation during neonatal cardiopulmonary resuscitation: are we ready for a clinical trial?

Jenny K. Koo, Po‐Yin Cheung, Gerhard Pichler, Anne Lee Solevåg et autres

Neonates requiring cardiopulmonary resuscitation (CPR) are at risk of mortality and neurodevelopmental injury. Poor outcomes following the need for chest compressions (CCs) in the delivery room prompt the critical need for improvements in resuscitation strategies. This article explores a technique of CPR …

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Early Echocardiographic Predictors of Eventual Need for Patent Ductus Arteriosus Treatment: A Retrospective Study

Jenny K. Koo, Nohemi Torres, Anup C. Katheria

OBJECTIVE: Hemodynamically significant patent ductus arteriosus (hsPDA) in preterm neonates is associated with end-organ injury including intraventricular hemorrhage. Early treatment may reduce morbidities but may result in overtreatment. This study aimed to examine the association between commonly obtained echocardiographic markers within the …

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Positive Pressure Ventilation in Preterm Infants in the Delivery Room: A Review of Current Practices, Challenges, and Emerging Technologies

Shivashankar Diggikar, Viraraghavan Vadakkencherry Ramaswamy, Jenny K. Koo, Arun Prasath et autres

BACKGROUND: A major proportion of preterm neonates require positive pressure ventilation (PPV) immediately after delivery. PPV may be administered through a face mask (FM) or nasal prongs. Current literature indicates that either of these are associated with similar outcomes. SUMMARY: Nonetheless, FM …

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