Rebecca Pitts

Proteomic risk score for early prediction of kidney disease progression in individuals with APOL1 high-risk genotypes

Chenyu Li, Shola M. Richards, Ghazal Z. Quinn, Amin Abedini et autres

Abstract Individuals of African ancestry carrying APOL1 (apolipoprotein L1) high-risk genotypes face a markedly increased risk of kidney failure, yet tools to identify those individuals likely to progress to chronic kidney disease are lacking. Here we profiled plasma proteomes of 851 Penn …

us, ch, dk (code pays fourni par la source)

Author Correction: Serum proteomics reveal APOE-ε4-dependent and APOE-ε4-independent protein signatures in Alzheimer’s disease

Elisabet A. Frick, Valur Emilsson, Þórarinn Jónmundsson, Anna E. Steindorsdottir et autres

In the version of this article initially published, in Fig. 4a, the blue data points were presented as odds ratios in the same panels and on the same scale as the yellow data points (hazard ratios), which was incorrect. The blue data …

is, us, es (code pays fourni par la source)

Serum proteomics reveal APOE-ε4-dependent and APOE-ε4-independent protein signatures in Alzheimer’s disease

Elisabet A. Frick, Valur Emilsson, Þórarinn Jónmundsson, Anna E. Steindorsdottir et autres

A deeper understanding of the molecular processes underlying late-onset Alzheimer’s disease (LOAD) could aid in biomarker and drug target discovery. Using high-throughput serum proteomics in the prospective population-based Age, Gene/Environment Susceptibility–Reykjavik Study (AGES) cohort of 5,127 older Icelandic adults (mean age, 76.6 …

is, us, es (code pays fourni par la source)

Serum proteomics reveals APOE dependent and independent protein signatures in Alzheimer’s disease

Valborg Guðmundsdóttir, Elisabet A. Frick, Valur Emilsson, Þórarinn Jónmundsson et autres

ch, us, is, es, cn (code pays fourni par la source)

Non‐invasive candidate protein signature predicts hepatic venous pressure gradient reduction in cirrhotic patients after sustained virologic response

Shola M. Richards, Fang Guo, Heng Zou, Florian Nigsch et autres

BACKGROUND AND AIMS: A reduction in hepatic venous pressure gradient (HVPG) is the most accurate marker for assessing the severity of portal hypertension and the effectiveness of intervention treatments. This study aimed to evaluate the prognostic potential of blood-based proteomic biomarkers in …

ch, es, us (code pays fourni par la source)

A proteogenomic signature of age-related macular degeneration in blood

Valur Emilsson, Elías F. Guðmundsson, Þórarinn Jónmundsson, Brynjolfur G. Jonsson et autres

Age-related macular degeneration (AMD) is one of the most common causes of visual impairment in the elderly, with a complex and still poorly understood etiology. Whole-genome association studies have discovered 34 genomic regions associated with AMD. However, the genes and cognate proteins …

is, us, ch (code pays fourni par la source)

ADAMTSL2 protein and a soluble biomarker signature identify at-risk non-alcoholic steatohepatitis and fibrosis in adults with NAFLD

Kathleen E. Corey, Rebecca Pitts, Michelle Lai, Joseph Loureiro et autres

BACKGROUND & AIMS: Identifying fibrosis in non-alcoholic fatty liver disease (NAFLD) is essential to predict liver-related outcomes and guide treatment decisions. A protein-based signature of fibrosis could serve as a valuable, non-invasive diagnostic tool. This study sought to identify circulating proteins associated …

us (code pays fourni par la source)

A Proteogenomic Signature of Age-related Macular Degeneration in Blood

Valur Emilsson, Elías F. Guðmundsson, Þórarinn Jónmundsson, Michael Twarog et autres

Abstract Age-related macular degeneration (AMD) is one of the most frequent causes of visual impairment in the elderly population. The overall etiology of AMD is complex and still poorly understood, though age, obesity, smoking, and high-density lipoprotein are known risk factors. In …

is, us (code pays fourni par la source)

Co-regulatory networks of human serum proteins link genetics to disease

Valur Emilsson, Marjan Ilkov, John R. Lamb, Nancy Finkel et autres

Proteins circulating in the blood are critical for age-related disease processes; however, the serum proteome has remained largely unexplored. To this end, 4137 proteins covering most predicted extracellular proteins were measured in the serum of 5457 Icelanders over 65 years of age. …

is, us (code pays fourni par la source)

Application of Large-Scale Aptamer-Based Proteomic Profiling to Planned Myocardial Infarctions

Jaison Jacob, Debby Ngo, Nancy Finkel, Rebecca Pitts et autres

Background: Emerging proteomic technologies using novel affinity-based reagents allow for efficient multiplexing with high-sample throughput. To identify early biomarkers of myocardial injury, we recently applied an aptamer-based proteomic profiling platform that measures 1129 proteins to samples from patients undergoing septal alcohol ablation …

br, us (code pays fourni par la source)

Jovian Mid-Infrared Aurora: Retrospective Analysis of Variability and Cassini Flyby Measurements in Preparation for Juno

Theodor Kostiuk, T. Hewagama, T. A. Livengood, K. E. Fast et autres

A Novel Approach Using MALDI-TOF/TOF Mass Spectrometry and Prestructured Sample Supports (AnchorChip Technology) for Proteomic Profiling and Protein Identification

Sau-Mei Leung, Rebecca Pitts

Mass spectrometry (MS)-based proteomic profiling and protein identification has become a powerful tool for the discovery of new disease biomarkers. Among the MS platforms, matrix-assisted laser desorption/ionization time-of-flight/time-of-flight (MALDI-TOF/TOF) MS offers high sample throughput and the flexibility to couple with different off-line …

us (code pays fourni par la source)