Antonella Mancusi

CXCR4-dependent migratory differences between peripheral Tregs and Tcons preserve GvL while limiting GvHD after HSCT

Loredana Ruggeri, Antonio Pierini, Elena Urbani, Sara Ciardelli et autres

Although studies on HLA-haploidentical hematopoietic stem cells transplant (HSCT) for high-risk acute myeloid leukemia (AML) showed that regulatory and conventional T-lymphocyte (Treg/Tcon) immunotherapy prevents graft-versus-host disease (GvHD) while it exerts T-cell dependent graft-versus-leukemia (GvL) effect, its mechanism is less known. The present …

it, us (code pays fourni par la source)

Role of donor regulatory T-cell adoptive immunotherapy in B-cell immunity after hematopoietic cell transplantation

Sara Piccinelli, Roberto Limongello, Valerio Viglione, Eni Hohxa et autres

Not available.

it (code pays fourni par la source)

Novel conditioning and prophylaxis regimens for relapse prevention

Antonella Mancusi, Loredana Ruggeri, Antonio Pierini

The last 20 years witnessed relevant clinical advancements in the field of hematopoietic cell transplantation (HCT) for leukemia patients. The introduction of novel conditioning regimens, a better prophylaxis and management of graft- versus-host disease, and an ameliorated posttransplant support system improved safety …

it (code pays fourni par la source)

Dissecting the link between PD-1/PD-L1-based immunotherapy and cancer pain: mechanisms, research implications, and artificial intelligence perspectives

Marco Cascella, Lucia Santaniello, Milena Mottola, Antonella Mancusi et autres

Cancer-related pain represents one of the most common complaints of cancer patients especially for those with advanced-stage of disease and/or bone metastases. More effective therapeutic strategies are needed not only to improve the survival of cancer patients but also to relieve cancer-related …

it (code pays fourni par la source)

Safety of 20Gy Total Marrow Irradiation Based Conditioning Regimen for Hematopoietic Cell Transplantation with T Cell Adoptive Immunotherapy

Francesco Zorutti, Simonetta Saldi, Loredana Ruggeri, Valerio Viglione et autres

Introduction Acute leukemia patients with chemorefractory active disease at the time of hematopoietic stem cell transplantation (HSCT) have high-risk of post-transplant relapse and a poor prognosis. Indeed, utility of HSCT has been questioned in this unfavorable subgroup of patients. We recently employed …

it, us (code pays fourni par la source)

Treg Selection from G-CSF Stimulated Donors Improves Outcomes of Immune-Suppression Free HLA-Haploidentical Hematopoietic Cell Transplantation with T Cell Adoptive Immunotherapy

Antonio Pierini, Loredana Ruggeri, Valerio Viglione, Simonetta Saldi et autres

Background Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative therapy for patients with high-risk acute leukemias. We have recently employed an immune-suppression free HSCT approach with regulatory and conventional T cell immunotherapy (Treg-Tcon HSCT) for acute myeloid leukemia (AML) patients …

it (code pays fourni par la source)

How adoptive transfer of components of the donor immune system boosts GvL and prevents GvHD in HLA-haploidentical hematopoietic transplantation for acute leukemia

Andrea Velardi, Antonella Mancusi, Loredana Ruggeri, Antonio Pierini

it (code pays fourni par la source)

Blinatumomab Redirects Donor Lymphocytes against CD19+ Acute Lymphoblastic Leukemia without Relevant Bystander Alloreactivity after Haploidentical Hematopoietic Stem Cell Transplantation

Antonella Mancusi, Francesco Zorutti, Loredana Ruggeri, Samanta Bonato et autres

Blinatumomab alone or with donor leukocyte infusions (DLI) has been used after allogeneic hematopoietic stem cell transplantation (HSCT) as a salvage therapy in relapsing patients with CD19+ hematological malignancies. It was effective in a fraction of them, with low incidence of Graft-versus-Host …

it (code pays fourni par la source)

P813: MALIGNANT PLASMA CELLS PROMOTE EXPANSION OF REGULATORY T CELLS TO CREATE A PROTECTIVE “IMMUNE SHIELD”

Roberto Limongello, Antonella Mancusi, Andrea Marra, Yu J. Shen et autres

Topic: 13. Myeloma and other monoclonal gammopathies - Biology & Translational Research Background: Multiple myeloma (MM) remains an incurable disease due to expanding clonal plasma cells (PCs). CD4+CD25+FoxP3+ regulatory T cells (Treg) appear to support bone marrow (BM) PC maintenance (Glatman Z.A., …

it, us (code pays fourni par la source)

PB2442: BLINATUMOMAB REDIRECTS DONOR LYMPHOCYTES AGAINST CD19+ ALL WITHOUT INCREASING THE RISK OF BYSTANDER ALLOREACTIVITY AFTER HAPLOIDENTICAL HEMATOPOIETIC CELL TRANSPLANTATION

Antonella Mancusi, Francesco Zorutti, Loredana Ruggeri, Samanta Bonato et autres

Topic: 22. Stem cell transplantation - Clinical Background: TCR/CD19 bispecific antibody Blinatumomab is approved in patients with acute lymphoblastic leukemia (ALL). Blinatumomab alone or in combination with donor leukocyte infusions (DLI) has also been used after allogeneic hematopoietic cell transplantation (HCT) as …

it (code pays fourni par la source)

HLA-Matched Treg/Tcon Allogeneic Hematopoietic Cell Transplantation Is Safe and Ensures Remarkable Chronic GvHD/Leukemia Free Survival in High-Risk Leukemia Patients

Antonio Pierini, Loredana Ruggeri, Simonetta Saldi, Sara Tricarico et autres

it (code pays fourni par la source)

Acute GvHD after HLA-Haploidentical Hematopoietic Cell Transplantation with Regulatory and Conventional T Cell Immunotherapy Does Not Adversely Affect Transplantation Outcomes

Samanta Bonato, Rachele Del Sordo, Antonella Mancusi, Adelmo Terenzi et autres

Abstract Introduction Adoptive immunotherapy with CD4+CD25+FOXP3+ regulatory T cells (Tregs) and conventional T cells (Tcons) has been employed after allogeneic hematopoietic stem cell transplantation (HSCT) to prevent Graft-versus-Host Disease (GvHD) while mantaining Graft-versus-Leukemia effect in the absence of any further immune suppressive …

it (code pays fourni par la source)