Karthik Mallilankaraman

Death‐Associated Protein 3 Triggers Intrinsic Apoptosis via Miro1 Upon Inducing Intracellular Calcium Changes

Dongxue Hu, Qiaoyun Yang, Hongxu Xian, Minghao Wang et autres

ABSTRACT Mitochondrial homeostasis is essential for cell survival and function, necessitating quality control mechanisms to ensure a healthy mitochondrial network. Death‐associated protein 3 (DAP3) serves as a subunit of the mitochondrial ribosome, playing a pivotal role in the translation of mitochondrial‐encoded proteins. …

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Editorial: Mitochondria at the nexus of metabolism, aging, and disease

Karthik Mallilankaraman, Brian K. Kennedy, Vincenzo Sorrentino, Alessandro Luciani

Editorial on the Research Topic Mitochondria at the nexus of metabolism, aging, and disease Mitochondria, the intracellular powerhouses responsible for converting nutrients into energy (in the form of ATP or heat), are highly dynamic, double-membraned organelles.They play a crucial role in a …

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Role of Mitogen-Activated Protein (MAP) Kinase Pathways in Metabolic Diseases

Gavin Ng, Zachary Wai-Loon Loh, David Y. Fann, Karthik Mallilankaraman et autres

Physiological processes that govern the normal functioning of mammalian cells are regulated by a myriad of signalling pathways. Mammalian mitogen-activated protein (MAP) kinases constitute one of the major signalling arms and have been broadly classified into four groups that include extracellular signal-regulated …

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Multiomics analyses reveal dynamic bioenergetic pathways and functional remodeling of the heart during intermittent fasting

Thiruma V. Arumugam, Asfa Alli‐Shaik, Elisa A. Liehn, Sharmelee Selvaraji et autres

Intermittent fasting (IF) has been shown to reduce cardiovascular risk factors in both animals and humans, and can protect the heart against ischemic injury in models of myocardial infarction. However, the underlying molecular mechanisms behind these effects remain unclear. To shed light …

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Author Response: Multiomics analyses reveal dynamic bioenergetic pathways and functional remodeling of the heart during intermittent fasting

Thiruma V. Arumugam, Asfa Alli‐Shaik, Elisa A. Liehn, Sharmelee Selvaraji et autres

Intermittent fasting orchestrates molecular shifts, yielding cardiovascular improvements, revealing novel cardioprotective mechanisms, and suggesting innovative pharmacological strategies for cardiovascular disease prevention and treatment.

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Reviewer #1 (Public Review): Multiomics Analyses Reveal Dynamic Bioenergetic Pathways and Functional Remodeling of the Heart During Intermittent Fasting

Arumugam Thiruma V., Alli-Shaik Asfa, Liehn Elisa A., Selvaraji Sharmelee et autres

Intermittent fasting (IF) reduces cardiovascular risk factors in animals and humans, and can protect the heart against ischemic injury in models of myocardial infarction, but the underlying molecular mechanisms are unknown. To delineate molecular and cellular adaptations of the heart to IF, …

kr, au, sg, de (code pays fourni par la source)

Author Response: Multiomics Analyses Reveal Dynamic Bioenergetic Pathways and Functional Remodeling of the Heart During Intermittent Fasting

Thiruma V. Arumugam, Asfa Alli‐Shaik, Elisa A. Liehn, Sharmelee Selvaraji et autres

Intermittent fasting (IF) reduces cardiovascular risk factors in animals and humans, and can protect the heart against ischemic injury in models of myocardial infarction, but the underlying molecular mechanisms are unknown. To delineate molecular and cellular adaptations of the heart to IF, …

sg, kr, de, us (code pays fourni par la source)

Multiomics analyses reveal dynamic bioenergetic pathways and functional remodeling of the heart during intermittent fasting

Thiruma V. Arumugam, Asfa Alli‐Shaik, Elisa A. Liehn, Sharmelee Selvaraji et autres

Intermittent fasting (IF) has been shown to reduce cardiovascular risk factors in both animals and humans, and can protect the heart against ischemic injury in models of myocardial infarction. However, the underlying molecular mechanisms behind these effects remain unclear. To shed light …

sg, au, kr, dk, jp, in, ro, us, de (code pays fourni par la source)

Multiomics Analyses Reveal Dynamic Bioenergetic Pathways and Functional Remodeling of the Heart During Intermittent Fasting

Thiruma V. Arumugam, Asfa Alli‐Shaik, Elisa A. Liehn, Sharmelee Selvaraji et autres

Abstract Aims Intermittent fasting (IF) reduces cardiovascular risk factors in animals and humans, and can protect the heart against ischemic injury in models of myocardial infarction, but the underlying molecular mechanisms are unknown. To delineate molecular and cellular adaptations of the heart …

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FUNCTIONAL AGEING: A Science-Technology-Society Approach to teach Ageing and Age-related Diseases

Gavin Ng, Vismitha Rajeev, Sharmelee Selvaraji, Karthik Mallilankaraman et autres

Abstract Purpose Ageing is a complex biological process that involves numerous genes and pathways. Experimental studies have identified several of these genes and pathways that that can extend or shorten an individual’s lifespan. Understanding these genes and pathways can help develop interventions …

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Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain

Gavin Yong-Quan Ng, Dominic Paul Lee Kok Sheng, Han‐Gyu Bae, Sung Wook Kang et autres

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Epstein-Barr virus-induced ectopic CD137 expression helps nasopharyngeal carcinoma to escape immune surveillance and enables targeting by chimeric antigen receptors

Mukul Prasad, Sashigala Ponnalagu, Qun Zeng, Khang Luu et autres

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