Olivier Ayrault

INTEGRATED PROTEOMIC AND TRANSCRIPTOMIC ANALYSIS REVEALS DISTINCT BIOLOGICAL RESPONSES TO PROTON AND X-RAY IRRADIATION IN GROUP 3 MEDULLOBLASTOMA CELL LINES

Ramon Handerson Gomes Teles, Jacob Diaz, Cristèle Gilbert, Julie Espenon et autres

fr, es (code pays fourni par la source)

CONVENTIONAL PROTON THERAPY AND PROTON-FLASH INDUCE A DIFFERENT PROTEOMIC PROFILE IN HEALTHY BRAINS OF RATS

Emmanuel Jouglar, Lorea Iturri, Marjorie Juchaux, Annaïg Bertho et autres

fr, es (code pays fourni par la source)

PROTEOMIC PROFILING OF RAT ORTHOTOPIC GLIOBLASTOMA AND HEALTHY BRAIN FOLLOWING PROTON MINIBEAN RADIATION THERAPY

Loris Roncali, Lorea Iturri, Cristèle Gilbert, Julie Espenon et autres

fr, es (code pays fourni par la source)

Ras-Responsive Element Binding Protein 1 regulates survival of Group 3 medulloblastoma

Meher Beigi Masihi, Kendall R. Chambers, Sergey Pampou, Brian Gudenas et autres

Medulloblastoma (MB) is the most common malignant pediatric brain tumor, and Group 3 (G3, MYC-driven) MB has the worst prognosis. Despite advances in molecular classification, oncogenic drivers of G3 MB remain poorly defined. To identify such drivers, we profiled transcription factor expression …

us, fr, jp, ca, gb (code pays fourni par la source)

Functionally distinct ALK and ROS1 fusions detected in infant-type hemispheric gliomas converge on STAT3 and SHP2 activation

Andreas Postlmayr, Astrid Sanchez Bergman, Jacob Torrejon Diaz, Bernard Ciraulo et autres

ALK and ROS1 fusions are emerging as key drivers of infant-type hemispheric gliomas (IHG). With diverse gene partners, the impact of ALK and ROS1 oncoprotein heterogeneity on glioma biology remains unknown. We developed an integrative phospho-proteomic and transcriptomic approach to discover biological …

ch, fr, de, ca (code pays fourni par la source)

Nanopore sequencing as a cutting-edge technology for medulloblastoma classification

Mathilde Filser, Jacob Torrejón, Kevin Merchadou, Christelle Dufour et autres

BACKGROUND: Medulloblastoma (MB) is one of the most prevalent embryonal malignant brain tumors. Current classification organizes these tumors into 4 molecular subgroups (WNT, SHH, Group 3, and Group 4 MB). Recently, a comprehensive classification has been established, identifying numerous subtypes, some of …

fr, Tunisie (code pays fourni par la source)

MDB-57. PROTEOMIC ANALYSIS REVEALS AMBRA1 AS A NEW CRL3REN/KCTD11 SUBSTRATE PROMOTING SONIC HEDGEHOG-DEPENDENT MEDULLOBLASTOMA

Irene Basili, Paola Infante, Marilisa Conenna, Flavia Bernardi et autres

Abstract BACKGROUND Sonic Hedgehog (SHH) signaling pathway is fundamental for a proper embryonic development and its uncontrolled activation is responsible for various cancers. One the most relevant SHH-dependent tumors is medulloblastoma (MB), a highly heterogeneous brain malignancy that predominantly occurs in childhood. …

fr, it (code pays fourni par la source)

NFS-02. MEDULLOBLASTOMAS WITH ELP1 PATHOGENIC VARIANTS: A WEAKLY PENETRANT SYNDROME WITH A RESTRICTED SPECTRUM IN A LIMITED AGE WINDOW

Léa Guerrini‐Rousseau, Julien Masliah‐Planchon, Mathilde Filser, Arnault Tauziède‐Espariat et autres

Abstract BACKGROUND Medulloblastomas (MB) Sonic hedgehog (SHH) subtype are associated with a cancer predisposition syndrome (CPS) in about 15% of cases, the most frequent being related to ELP1 pathogenic variant (PV). The aim of our study is to better evaluate penetrance of …

fr, nl (code pays fourni par la source)

MDB-12. NANOPORE SEQUENCING AS A CUTTING-EDGE TECHNOLOGY FOR MEDULLOBLASTOMA CLASSIFICATION

Mathilde Filser, Jacob Torrejón, Kevin Merchadou, Elodie Girard et autres

Abstract INTRODUCTION Medulloblastoma (MB) is one of the most prevalent embryonal malignant brain tumors, divided into four distinct molecular subgroups (WNT, SHH, group 3, and group 4) with its individual prognosis. A more extensive classification of MB has recently been provided, identifying …

fr (code pays fourni par la source)

METB-03. SOLID PEDIATRIC TUMORS IN MICE REVEAL MODEL-SPECIFIC GLOBAL DNA METHYLATION AND CNV PROFILES CORRESPONDING TO HUMAN COUNTERPARTS

Melanie Schoof, Tuyu Zheng, Martin Sill, Roland Imle et autres

Abstract BACKGROUND The analysis and comparison of global DNA methylation patterns has become a gold standard in modern neuropathology. For human central nervous system (CNS) tumors and other cancers, the research community has collected thousands of methylation profiles, leading to the discovery …

de, ch, jp, gb, fr, us, se (code pays fourni par la source)

Cancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression

Ryo Shiraishi, Gabriele Cancila, Kohei Kumegawa, Jacob Torrejón et autres

jp, fr, de, us (code pays fourni par la source)

Medulloblastomas with ELP1 pathogenic variants: A weakly penetrant syndrome with a restricted spectrum in a limited age window

Léa Guerrini‐Rousseau, Julien Masliah‐Planchon, Mathilde Filser, Arnault Tauziède‐Espariat et autres

Abstract Background ELP1 pathogenic variants (PV) have been recently identified as the most frequent variants predisposing to Sonic Hedgehog (SHH) medulloblastomas (MB); however, guidelines are still lacking for genetic counseling in this new syndrome. Methods We retrospectively reviewed clinical and genetic data …

fr, nl (code pays fourni par la source)