Yuanyuan Xie

Continuous-Flow Kinetic Analysis of TBD-Catalyzed Aminolysis of d -(−)-Pantolactone Using Flow-Rate Ramping and Inline FTIR Spectroscopy

Jianxiang Zhu, Jiahui Li, Runqiu Shen, Yuwei Song et autres

Abstract The development of efficient and sustainable amide-bond-forming processes, together with their quantitative kinetic characterization, is of major significance to the fine chemical and pharmaceutical industries. In this study, the aminolysis of d-(−)-pantolactone (DPL) with pyrrolidine (Pyr), catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD), was …

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Design, synthesis, and evaluation of novel 5-aminolevulinic acid and 3-hydroxypyridinone conjugates for enhanced photodynamic therapy in triple-negative breast cancer

Jinhui Ren, Jingqi Zhang, Yan Liu, Yikai Shen et autres

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Electrochemically Enabled C–H Arylation of Anilines

Zhenhua Li, Fenghao Dai, Lijun Chen, Xin Lv et autres

Electrochemistry enables the direct, mild generation of aryl radicals under metal-free conditions for the regioselective C-H arylation of anilines. This operationally simple protocol, which requires no external oxidant, employs an undivided cell and proceeds via direct anodic electron transfer at ambient temperature, …

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Prior Knowledge‐Based Bayesian Optimization With Real‐Time Process Analytical Technology for the Transition From Batch to Continuous Flow Biocatalysis: Lipase‐Mediated Dynamic Kinetic Resolution

Yuwei Song, Chasheng He, Guihua Luo, Weike Su et autres

The synthesis of high‐value chiral pharmaceutical intermediates typically requires efficient, scalable, and stereoselective processes. Here, we report an integrated batch‐flow chemoenzymatic platform for the asymmetric synthesis of ( S )‐(‐)‐2‐acetoxy‐2‐phenylethanenitrile with Novozym 435. This system uniquely combines a continuous‐flow packed‐bed reactor with …

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Targeting the Heme biosynthesis pathway: strategies to enhance 5-ALA-mediated photodynamic therapy

Jinhui Ren, Yinghui Li, Jiani Fu, Rubing Zhou et autres

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Dual-masked cathepsin B-activated 5-aminolevulinic acid prodrugs with enhanced photodynamic cytotoxicity

Yikai Shen, Keren Wang, Yan Liu, Hui Xu et autres

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Balancing the site abundance and coking resistance of active metal domain for efficient hydrodeoxygenation of lignin pyrolysis vapor over Ni/Al2O3

Yuanyuan Xie, Chuo Du, Hongfei Xiao, Jinhou Fang et autres

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Charge-programmable carbon dots tailored by amino acid pKa spectrum for spatiotemporally controlled siRNA delivery and antiviral protection in plants

Fang Wang, Xueyang Ji, Yan Zhao, J Hu et autres

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In‐situ Electropolymerized Bipolar Organic Cathode Material for High‐Voltage Sodium Dual‐Ion Batteries with Long‐Cycle Performances

Yushan You, Yuanyuan Xie, Xing Liu, Xin Chen et autres

Comprehensive Summary Organic electrode materials offer advantages such as structural tunability and high redox reversibility. However, they still face challenges in pursuing long‐term cycling stability and high operating voltage. To address these challenges, a donor‐acceptor monomer (TPA‐PQ) integrating phenanthrenequinone (n‐type) and triphenylamine …

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One-pot synthesis of graphene oxide supported nanoscale zero-valent nickel as a novel nanotrap toward highly efficient uranyl capture

Shaoming Zhu, Weijiang Wang, Yuxin Ding, Jianhua Zhang et autres

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Nano-FeMOFs stabilized by montmorillonite for rapid removing dyes in aqueous systems

Yuanyuan Xie, Junhui Guo, Yufeng He, Yaping Zhang et autres

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LPC18 :0 Secreted by Exogenous Neural Stem Cells Potentiates Neurogenesis and Functional Recovery via GPR55 ‐Mediated Signalling in Spinal Cord Injury

Dong Chen, Shuo Liu, Lijun Tu, Congwang Xu et autres

Spinal cord injury (SCI) is a devastating condition with limited therapeutic options. Although neural stem cell (NSC) transplantation shows regenerative potential, its efficacy is constrained by the hostile post-injury microenvironment. Here, we employed untargeted metabolomics to investigate metabolic reprogramming induced by NSC-loaded …

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