Una O’Doherty

Clonal dynamics of HIV-infected and uninfected T cells

S. L. Weissman, Ashley M. Ginda, Alfonso Oceguera, Liam Swiggard et autres

BACKGROUND: The HIV reservoir was once considered to be transcriptionally silent. Evidence is emerging that a substantial portion of the reservoir is transcriptionally active. We explore the consequences of transcriptionally active proviruses on the infected T cell by longitudinally monitoring the fate …

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B-Cell Subset Representation Predicts SARS-CoV-2 Vaccine Response in Solid Organ Transplant Recipients

James J. Knox, Ingi Lee, Emily A. Blumberg, Aaron M. Rosenfeld et autres

BACKGROUND: Solid organ transplant recipients (SOTRs) suffer increased morbidity and mortality due, in part, to chronic immunosuppression. The determination of an individual's immune competence is currently difficult but would improve risk assessment and inform medical decisions. We reasoned that correlating qualitative and …

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PP5.9 – 00108 Tracking infected cell fate using a barcoded virus

Ana Cabrera, Sam Weissman, Ashley M. Ginda, Una O’Doherty

Machine Learning Bolsters Evidence That D1, Nef, and Tat Influence HIV Reservoir Dynamics

LaMont Cannon, Sophia Fehrman, Marilia Rita Pinzone, Sam Weissman et autres

Background: The primary hurdle to curing HIV is due to the establishment of a reservoir early in infection. In an effort to find new treatment strategies, we and others have focused on understanding the selection pressures exerted on the reservoir by studying …

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Highlights from the Inaugural HIV Reservoirs and Immune Control Conference, October 1st–4th 2023, Malahide Ireland

Una O’Doherty, Javier Martinez Picado, Asier Sáez‐Cirión

The inaugural FASEB HIV Reservoirs and Immune Control Conference brought researchers together from across the globe to discuss reservoir dynamics in clinical cohorts. It extended over 4 days in the seaside town of Malahide, Ireland. The scientific sessions covered a broad range …

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Red cell exchange for rapid leukoreduction in adults with hyperleukocytosis and leukostasis

Ethan A. Mack, Meaghan C. Dougher, Ashley M. Ginda, Caitlin Cahill et autres

ABSTRACT: We show that red cell exchange (RCE) treats hyperleukocytosis in acute leukemia. RCE provided similar leukoreduction to standard therapeutic leukoreduction and could be superior in patients with severe anemia or monocytic leukemias or when requiring rapid treatment.

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Increased Proliferative Drive of Lymphocytes in Sickle Cell Disease

Ashley M. Ginda, Jingyue Zhang, Wenzhao Meng, Charlotte Kearns et autres

Introduction Patients with sickle cell disease (SCD) have higher levels of inflammation which plays a prominent role in disease pathogenesis. It is well known that individuals with SCD have a higher erythropoietic drive given the ~20 day life span of their red …

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OA5‐AM23‐MN‐36 | Red Cell Exchange for Rapid Leukoreduction in Adults with Hyperleukocytosis and Leukostasis

E. Mack, M. Dougher, Melissa Murter, Yvette Co Tanhehco et autres

Hyperleukocytosis with leukostasis is a complication of acute leukemias that is associated with significant morbidity. While cytoreductive chemotherapy can reduce the white blood cell count (WBC) and improve symptoms of leukostasis, therapeutic leukocytapheresis (TLP) can rapidly reduce WBC when needed. Notably, some …

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Serotonin reduction in post-acute sequelae of viral infection

Andrea C. Wong, Ashwarya S. Devason, Iboro C. Umana, Timothy O. Cox et autres

Post-acute sequelae of COVID-19 (PASC, "Long COVID") pose a significant global health challenge. The pathophysiology is unknown, and no effective treatments have been found to date. Several hypotheses have been formulated to explain the etiology of PASC, including viral persistence, chronic inflammation, …

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Current HIV/SIV Reservoir Assays for Preclinical and Clinical Applications: Recommendations from the Experts 2022 NIAID Workshop Summary

Brigitte E. Sanders-Beer, Nancie M. Archin, Zabrina L. Brumme, Michael Paul Busch et autres

Since the first HIV-cured person was reported in 2009, a strong interest in developing highly sensitive HIV and SIV reservoir assays has emerged. In particular, the question arose about the comparative value of state-of-the-art assays to measure and characterize the HIV reservoir, …

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Rapid manufacturing of non-activated potent CAR T cells

Saba Ghassemi, Joseph S. Durgin, Selene Nuñez-Cruz, Jai Patel et autres

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Femtomolar SARS-CoV-2 Antigen Detection Using the Microbubbling Digital Assay with Smartphone Readout Enables Antigen Burden Quantitation and Tracking

Hui Chen, Zhao Li, Sheng Feng, Melissa Richard‐Greenblatt et autres

BACKGROUND: High-sensitivity severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen assays are desirable to mitigate false negative results. Limited data are available to quantify and track SARS-CoV-2 antigen burden in respiratory samples from different populations. METHODS: We developed the Microbubbling SARS-CoV-2 Antigen …

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