Accès ouvert
2026
article
OpenAlex
Nikki Wanders, Marvin Martens, Marco Kelders, Sven Manse et autres
Background: Cancer-associated cachexia (CAC) can affect up to 80% of patients with late-stage cancer and is characterized by depletion of skeletal muscle mass with or without loss of fat tissue. No effective treatments are currently available, and reversing CAC requires understanding the …
nl, gb
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Sandra Jessica van Krimpen, Sami O. Simons, AM Schols, RAMON C. J. LANGEN et autres
INTRODUCTION: Muscle weakness represents a significant clinical problem in chronic obstructive pulmonary disease (COPD). During exacerbations of COPD (ECOPD), inflammation, oxidative stress, malnutrition, disuse, hypoxia, and glucocorticoid (GC) levels increase and converge, further aggravating skeletal muscle impairment with GC signaling as a …
nl
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Annemarie J. F. Westheim, Ludwig J. Dubois, Elia Prades‐Sagarra, Jiyang Chan et autres
Several studies demonstrated curative responses of combined radio-immunotherapy, although not standard-of-care for most cancers. Increased fiber intake has been associated with improved radiotherapy and immunotherapy outcomes, but fiber compositions' impact remains unclear. This study aimed to explore whether dietary fiber composition influences …
nl
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Sandra Jessica van Krimpen, Justine Michelle Webster, Peiyu Qiu, Pauline Henrot et autres
Abstract Disclosure: S.J. van Krimpen: None. J.M. Webster: None. P. Qiu: None. P. Henrot: None. B. Rezaeifar: None. S.O. Simons: None. A.M. Schols: None. H.R. Gosker: None. R.C. Langen: None. Chronic obstructive pulmonary disease (COPD) is the most common chronic respiratory disease …
nl
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Sandra Jessica van Krimpen, Justine Michelle Webster, Peiyu Qiu, Pauline Henrot et autres
Abstract Disclosure: S.J. van Krimpen: None. J.M. Webster: None. P. Qiu: None. P. Henrot: None. B. Rezaeifar: None. S.O. Simons: None. A.M. Schols: None. R.C. Langen: None. H.R. Gosker: None. Chronic obstructive pulmonary disease (COPD) is the most common chronic respiratory disease …
nl
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Justine Michelle Webster, Sandra Jessica van Krimpen, Peiyu Qiu, Behzad Rezaeifar et autres
COPD is often accompanied by muscle wasting. Muscle wasting intensifies during exacerbations of COPD (ECOPD), possibly driven by glucocorticoids (GCs) that are given as standard-of-care treatment. GCs may aggravate muscle wasting through their catabolic actions, diminishing their overall therapeutic efficacy. To study …
nl
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Sven Manse, RAMON C. J. LANGEN, Irene H. Heijink, Harry R. Gosker
Chronic obstructive pulmonary disease (COPD) is often accompanied by muscle weakness, reduced muscle mass, and mitochondrial dysfunction. Muscle damaging insults such as mitochondrial impairment evoke a muscle regenerative response, though muscle regeneration appears blunted in COPD. We hypothesize that the systemic disease …
nl
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Sven Manse, Jalal Mosayebi Amroabadi, David Baião Barata, Pauline Henrot et autres
Skeletal muscle (SKM) is known to engage in inter-organ crosstalk. As SKM impairments in COPD arise together with lung pathology, it is plausible that SKM impairments arise after interactions with diseased lung tissue. However, platforms for studying the direct impact of lung …
nl, fr
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Pauline Henrot, Jalal Mosayebi Amroabadi, Sven Manse, David Baião Barata et autres
Introduction: Muscle wasting is a hallmark of chronic obstructive pulmonary disease (COPD). As macrophages, recruited to injured tissues via chemotactic signalling such as the CXCL12-CXCR4 axis, play an important role in skeletal muscle homeostasis and pathology, a role in muscle impairment in …
nl
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Sandra Jessica van Krimpen, Justine Michelle Webster, Peiyu Qiu, Pauline Henrot et autres
COPD is often accompanied by muscle wasting. Muscle wasting intensifies during exacerbations of COPD (ECOPD), partially driven by glucocorticoids (GCs) given as standard-of-care treatment. As GC-driven wasting partially relies on myostatin signaling, we hypothesized that blocking its receptor (with CDD866) would attenuate …
nl, fr
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Kingsley Okechukwu Nwozor, Priscila Pineda-Villegas, Lei Wang, Marnix R. Jonker et autres
Background: Mitochondrial dysfunction has been observed in lung epithelial cells in COPD. We hypothesise that these abnormalities not only result in increased pro-inflammatory activity, but also impaired epithelial regeneration either indirectly or directly due to e.g. cellular senescence/exhaustion of self-renewal capacity. Aim: …
nl
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Jalal Mosayebi Amroabadi, Sven Manse, Luna I. G. C. Louwe, Pauline Henrot et autres
Pulmonary and skeletal muscle dysfunction often coincide in COPD, which may be a consequence of inter-organ crosstalk. Lung-derived factors may contribute to muscle deterioration, while muscle-derived myokines may influence lung homeostasis. Traditional static in vitro models fail to mimic inter-organ signaling dynamics. …
nl, fr
(code pays fourni par la source)