Heather A. Renna

Abiraterone Acetate Affects Gene Expression Profile in a Human Male Neuronal Cell Line: Potential Mechanism for Cognitive Deficits with Prostate Cancer Therapy

Shelly Gulkarov, Allison Bethanne Reiss, Ankita Srivastava, Jasper Lim-Goyette et autres

Background and Objectives: Cornerstone therapies for metastatic prostate cancer include androgen deprivation and androgen receptor pathway inhibition, but cognitive impairment is a recognized, life-altering potential adverse effect of this treatment. Abiraterone acetate (AA), an androgen receptor pathway and CYP17A1 inhibitor, suppresses androgen …

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IP49-30 REDUCED MENTAL ACUITY WITH HORMONE THERAPY IN PROSTATE CANCER: CHANGES IN NEURONAL GENE EXPRESSION AS A POTENTIAL MECHANISM

Shelly Gulkarov, Aaron E. Katz, Ankita Srivastava, Heather A. Renna et autres

Differential Cytokine Profiles in Prostate Cancer Under Treatment: Implications for Prognosis and Synergistic Therapy Design

Aaron Katz, Maryann Johnson, Lora J. Kasselman, Saba Ahmed et autres

Background/Objectives: Localized prostate cancer may be treated with total cryotherapy, focal cryotherapy, stereotactic body radiotherapy (SBRT), or radical prostatectomy (RP). However, the immune response to these therapies is not fully understood despite its potential importance in determining extent and timing of recovery, …

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Simufilam in Alzheimer’s Disease: Assessment of Efficacy of a Controversial Drug in Human Neuronal Cell Culture

Ankita Srivastava, Heather A. Renna, Tahmina Hossain, Thomas A. Palaia et autres

Background/Objectives: Alzheimer’s disease (AD) is a progressive multifactorial neurodegenerative disorder. Current AD therapies offer minimal benefits and do not prevent or repair neuronal damage. More effective therapeutic approaches are needed to restore normal bioenergetics and metabolic function to AD neurons. Simufilam is …

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Weight Reduction with GLP-1 Agonists and Paths for Discontinuation While Maintaining Weight Loss

Allison Bethanne Reiss, Shelly Gulkarov, Raymond Lau, Stanislaw P. Klek et autres

Worldwide, nearly 40% of adults are overweight and 13% are obese. Health consequences of excess weight include cardiovascular diseases, type 2 diabetes, dyslipidemia, and increased mortality. Treating obesity is challenging and calorie restriction often leads to rebound weight gain. Treatments such as …

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Extracellular vesicles from water kefir can interact with human neurons in vitro: a potential explanation for the role of probiotics consumption in mental health

Lora J. Kasselman, Saba Ahmed, Maryann Johnson, Ankita Srivastava et autres

Major depressive disorder is one of the most burdensome mental health disorders. Probiotics have been shown to ameliorate depressive symptoms, though the mechanism remains unclear. This study was conducted to investigate whether extracellular vesicles (EVs) extracted from the probiotic beverage water kefir …

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Plasma from type 1 diabetes patients promotes pro-atherogenic cholesterol transport in human macrophages

Siham D. Accacha, Iryna Voloshyna, Lora J. Kasselman, Jorge Mejia-Corletto et autres

Hyperglycemia, one of the major risk factors for atherosclerosis, leads to the accumulation of advanced glycation end products (AGEs), contributing to cardiovascular complications. Such accumulation may accelerate the progression of vascular disease in patients with diabetes. Reverse cholesterol transport (RCT) protein, ATP-binding …

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Nilotinib as a Prospective Treatment for Alzheimer’s Disease: Effect on Proteins Involved in Neurodegeneration and Neuronal Homeostasis

Ankita Srivastava, Heather A. Renna, Maryann Johnson, Katie Jane Sheehan et autres

Nilotinib, a tyrosine kinase inhibitor that targets the Abelson tyrosine kinase (c-Abl) signaling pathway, is FDA-approved to treat chronic myeloid leukemia. Nilotinib has properties indicative of a possible utility in neuroprotection that have prompted exploration of repurposing the drug for the treatment …

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Therapeutic Potential of P110 Peptide: New Insights into Treatment of Alzheimer’s Disease

Ankita Srivastava, Maryann Johnson, Heather A. Renna, Katie M. Sheehan et autres

Mitochondrial degeneration in various neurodegenerative diseases, specifically in Alzheimer's disease, involves excessive mitochondrial fission and reduced fusion, leading to cell damage. P110 is a seven-amino acid peptide that restores mitochondrial dynamics by acting as an inhibitor of mitochondrial fission. However, the role …

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Cholesterol deficiency as a mechanism for autism: A valproic acid model

Morgan R. Peltier, Jennifer Behbodikhah, Heather A. Renna, Saba Ahmed et autres

Dysregulated cholesterol metabolism represents an increasingly recognized feature of autism spectrum disorder (ASD). Children with fetal valproate syndrome caused by prenatal exposure to valproic acid (VPA), an anti-epileptic and mood-stabilizing drug, have a higher incidence of developing ASD. However, the role of …

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Hydroxychloroquine Effects on THP-1 Macrophage Cholesterol Handling: Cell Culture Studies Corresponding to the TARGET Cardiovascular Trial

Saba Ahmed, Justin Konig, Lora J. Kasselman, Heather A. Renna et autres

Background and Objectives: Cardiovascular (CV) risk is elevated in rheumatoid arthritis (RA). RA patient plasma causes pro-atherogenic derangements in cholesterol transport leading to macrophage foam cell formation (FCF). The TARGET randomized clinical trial compares CV benefits of 2 RA drug regimens. Hydoxychloroquine …

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Cognitive changes mediated by adenosine receptor blockade in a resveratrol-treated atherosclerosis-prone lupus mouse model

Lora J. Kasselman, Heather A. Renna, Iryna Voloshyna, Aaron Pinkhasov et autres

Background and aim: Resveratrol is a bioactive molecule used in dietary supplements and herbal medicines and consumed worldwide. Prior work showed that resveratrol's anti-atherogenic properties are mediated in part through the adenosine A2A receptor. The present study explores the potential contribution of …

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