Raíssa Fonseca

Retinoic acid and TGF-β orchestrate organ-specific programs of tissue residency

Andreas Obers, Tobias Poch, Grace Rodrigues, Susan N. Christo et autres

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Distinct epigenomic landscapes underlie tissue-specific memory T cell differentiation

Frank A. Buquicchio, Raíssa Fonseca, Patrick Yan, Fangyi Wang et autres

us, au (code pays fourni par la source)

Single-cell protein expression profiling resolves circulating and resident memory T cell diversity across tissues and infection contexts

Maximilien Evrard, Étienne Becht, Raíssa Fonseca, Andreas Obers et autres

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Runx3 drives a CD8+ T cell tissue residency program that is absent in CD4+ T cells

Raíssa Fonseca, Thomas N. Burn, Luke C. Gandolfo, Sapna Devi et autres

This is the accepted manuscript version of the work published in its final form as Fonseca, R., Burn, T. N., Gandolfo, L. C., Devi, S., Park, S. L., Obers, A., Evrard, M., Christo, S. N., Buquicchio, F. A., Lareau, C. A., McDonald, …

Runx3 drives a CD8+ T cell tissue residency program that is absent in CD4+ T cells

Raíssa Fonseca, Thomas N. Burn, Luke C. Gandolfo, Sapna Devi et autres

au, us, br (code pays fourni par la source)

A unique epigenomic landscape defines CD8 + tissue-resident memory T cells

Frank A. Buquicchio, Raíssa Fonseca, Julia A. Belk, Maximilien Evrard et autres

Summary Memory T cells provide rapid and long-term protection against infection and tumors. The memory CD8 + T cell repertoire contains phenotypically and transcriptionally heterogeneous subsets with specialized functions and recirculation patterns. While these T cell populations have been well characterized in …

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A Unique Epigenomic Landscape Defines CD8 + Tissue-Resident Memory T Cells

Frank A. Buquicchio, Raíssa Fonseca, Julia A. Belk, Maximilien Evrard et autres

us, au (code pays fourni par la source)

Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes

Maximilien Evrard, Erica Wynne-Jones, Changwei Peng, Yu Kato et autres

Tissue-resident memory T (TRM) cells provide long-lasting immune protection. One of the key events controlling TRM cell development is the local retention of TRM cell precursors coupled to downregulation of molecules necessary for tissue exit. Sphingosine-1-phosphate receptor 5 (S1PR5) is a migratory …

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Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity

Susan N. Christo, Maximilien Evrard, Simone L. Park, Luke C. Gandolfo et autres

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Organ-specific isoform selection of fatty acid binding proteins in tissue-resident lymphocytes

Raíssa Fonseca, Hannah Frizzell, Susan N. Christo, Maximilien Evrard et autres

Abstract Tissue-resident memory T (TRM) cells exist throughout the body where they are poised to mediate local immune responses. Although studies have defined a common mechanism of residency independent of location, there is likely to be a level of specialization that adapts …

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Developmental plasticity allows outside-in immune responses by resident memory T cells

Clare F. Quarnstrom, Raíssa Fonseca, Lalit K. Beura, Hazem E. Ghoneim et autres

Abstract Central memory T (TCM) cells patrol lymph nodes and perform conventional memory responses upon re-stimulation: proliferation, migration, and differentiation into diverse T cell subsets while also self-renewing. Resident memory T (TRM) cells are parked within single organs, share properties with terminal …

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Organ-specific isoform selection of fatty acid–binding proteins in tissue-resident lymphocytes

Hannah Frizzell, Raíssa Fonseca, Susan N. Christo, Maximilien Evrard et autres

Tissue-resident cells exhibit tissue-specific overlays to the T RM cell residency program that includes flexible FABP isoform selection tailored to the tissue of lodgment.

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