August John

Abstract 3610: Estrogen receptor-mediated pharmacogenomic eQTLs as predictors of endocrine therapy response in breast cancer

Martin Meng, Huanyao Gao, August John, Arnab Ghosh et autres

Abstract Background: Approximately 70% of breast cancers are estrogen receptor-positive (ER+), and endocrine therapies, including selective estrogen receptor modulators (SERMs) and aromatase inhibitors (AIs), are standard-of-care. However, interpatient variability in treatment response and relapse remains substantial, suggesting underlying germline pharmacogenomic factors that …

us (code pays fourni par la source)

Alcohol use disorder–associated gene FNDC4 alters glutamatergic and GABAergic neurogenesis in neural organoids

Xiujuan Zhu, August John, Sooan Kim, Li Wang et autres

Large-cohort GWAS for alcohol use disorder (AUD) drug treatment outcomes and AUD risk have repeatedly identified genetic loci that are splicing quantitative trait loci for the fibronectin III domain containing 4 (FNDC4) gene in the brain. However, FNDC4 function in the brain …

us (code pays fourni par la source)

Lestaurtinib’s antineoplastic activity converges on JAK/STAT signaling to inhibit treatment naïve and therapy resistant forms ovarian cancer

Esther Rodman, Michael J. Emch, Xiaonan Hou, Archit Bajaj et autres

Ovarian cancer is the deadliest gynecological malignancy, owing to its late-stage diagnosis and high rates of recurrence and resistance following standard-of-care treatment, highlighting the need for novel treatment approaches. Through an unbiased drug screen, we identified the kinase inhibitor, lestaurtinib, as a …

us, it (code pays fourni par la source)

Alcohol Use Disorder Associated Gene FNDC4 Alters Glutamatergic and GABAergic Neurogenesis

Xiujuan Zhu, August John, Li Ping Wang, Enci Ding et autres

ABSTRACT Large-cohort genome-wide association studies (GWAS) for alcohol use disorder (AUD) and AUD-related phenotypes have identified more than one hundred genetic loci. Functional study of those GWAS-identified loci might represent an important step toward understanding AUD pathophysiology. We found that genetic loci …

us (code pays fourni par la source)

Abstract 4297: Targeting metabolic dysfunction in prostate cancer: the anti-proliferative effects of ql47 through inhibition of dlat

Grace Nirmala Jesuthankaraj, August John, Huanyao Gao, Arun Kanakkanthara et autres

Background: Prostate cancer is the most common cancer in men in the United States with an estimated 288,300 new cases diagnosed in 2023. The treatment strategies include androgen deprivation therapies (ADTs) for metastatic prostate cancer (mPC) but 10-20% of patients eventually progress …

us (code pays fourni par la source)

A planimetric study of experimentally modeled infected wounds exposed to high-intensity pulsed broadband radiation

S. M. Chudnykh, V. S. Egorov, Х. А. Абдувосидов, A. V. Snitsar et autres

An experimental model of an infected wound was created in 90 Wistar rats using a mixture of cultures of Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Candida albicans. The animals are divided into 3 groups of 30 individuals. The first group consisted …

ru (code pays fourni par la source)

ROLE OFCDCP1 IN CARDIAC FIBROSIS: SPATIALLY RESOLVED GENE EXPRESSION PROFILE IN PRESSURE OVER-LOAD MOUSE MODEL

Irene Marín-Goñi, Li Wang, Min Wang, Rachad Ghazal et autres

us (code pays fourni par la source)

The Role of CENPK Splice Variant in Abiraterone Response in Metastatic Castration-Resistant Prostate Cancer

Minhong Huang, Sisi Qin, Huanyao Gao, Wootae Kim et autres

Most patients with metastatic prostate cancer eventually develop resistance to primary androgen deprivation therapy. To identify predictive biomarker for Abiraterone acetate/prednisone resistance, we screened alternative splice variants between responders and non-responders from the PROMOTE clinical study and pinned down the most significant …

us, kr (code pays fourni par la source)

Lestaurtinib’s antineoplastic activity converges on JAK/STAT signaling to inhibit advanced forms of therapy resistant ovarian cancer

Esther Rodman, Michael J. Emch, Xiaonan Hou, Archit Bajaj et autres

Ovarian cancer is the deadliest gynecological malignancy, owing to its late-stage diagnosis and high rates of recurrence and resistance following standard-of-care treatment, highlighting the need for novel treatment approaches. Through an unbiased drug screen, we identified the kinase inhibitor, lestaurtinib, as a …

us, it (code pays fourni par la source)

CO55 Incidence of Adverse Events with Pembrolizumab in Patients with Metastatic Castration-Resistant Prostate Cancer (mCRPC): A Systematic Review of Literature

Dinender K. Singla, S. Mahapatra, August John

in (code pays fourni par la source)

ReCorDE: a framework for identifying drug classes targeting shared vulnerabilities with applications to synergistic drug discovery

August John, Emily T. Ghose, Huanyao Gao, Meagan Luck et autres

Cancer is typically treated with combinatorial therapy, and such combinations may be synergistic. However, discovery of these combinations has proven difficult as brute force combinatorial screening approaches are both logistically complex and resource-intensive. Therefore, computational approaches to augment synergistic drug discovery are …

us (code pays fourni par la source)

Abstract 4563: Ferroptotic mechanism of drug induced toxicity of PARPi and AurKi in prostate cancer

August John, Kuntian Luo, Zhenkun Lou, Liewei Wang

Abstract BACKGROUND: Cancer is typically treated with a combination of drugs rather than monotherapy stratagems, but identification of synergistic drug combinations for the treatment of cancers is challenging. Here we present the combination of PARP and Aurora Kinase inhibitors synergize through induction …

us (code pays fourni par la source)