Kumar B. Rajan

Residential aircraft and road noise exposure, cognition, and Alzheimer’s dementia in a US cohort of older adults

Stephanie T. Grady, Ryan M. Andrews, Junenette L. Peters, Sara D. Adar et autres

Background: There is limited evidence of the associations between transportation noise and dementia risk. We examined associations of road and aircraft noise with cognitive function, cognitive decline, and Alzheimer's dementia (AD) in a cohort of older adults. Methods: We set our study …

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Higher Ultra-Processed Food Intake Is Associated With Faster Cognitive Decline in Older Adults

Xiaoran Liu, Jessica E Cha, Todd Beck, Christina Hutton et autres

Social network size and cognitive decline in older adults experiencing depressive symptoms and loneliness

Pankaja Desai, Ted Kheng Siang Ng, Kristin R. Krueger, Robert S. Wilson et autres

Objectives This paper evaluates the association between social network size and cognitive decline in older adults, approximately 61 years and older, with or without depressive symptoms and/or loneliness.Method This study is a secondary data analysis of the Chicago Health and Aging Project …

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Impact of kidney function on biomarkers of neurodegeneration, white matter hyperintensities, and cognition in older adults

Anisa Dhana, Charles DeCarli, Klodian Dhana, Pankaja Desai et autres

BACKGROUND: We evaluated the association between kidney function, neurodegenerative biomarkers (i.e., neurofilament light chain [NfL], total tau [t-tau], and glial fibrillary acidic protein [GFAP]), white matter hyperintensities, and global cognition. METHODS: The study consisted of 1207 participants living on the south side …

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Apolipoprotein E ε4-dependent associations between carotenoids and cognitive decline: Findings from the MIND (Mediterranean-DASH Intervention for Neurodegenerative delay) randomized controlled trial

Xiaoran Liu, Frank M. Sacks, Todd Beck, Christy Tangney et autres

BACKGROUND: Alzheimer disease (AD) prevention is a public health priority, yet the impact of dietary carotenoids on cognitive decline, particularly in apolipoprotein E (APOE) ε4 carriers, remains unclear. OBJECTIVES: The objective of this study was to examine whether the APOE ε4 genotype …

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Association of tailpipe-related and nontailpipe-related air pollution exposure with neuroimaging outcomes

Ryan M. Andrews, Stephanie T. Grady, Neelum T. Aggarwal, Todd Beck et autres

Background: Long-term exposure to air pollution may be related to neural atrophy or cerebrovascular pathology. A major source of air pollution is vehicle traffic, which is modifiable. In this study, we estimated associations between four traffic-related air pollutants and five neuroimaging biomarkers. …

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Sweetened Beverages and Incident All-Cause Dementia Among Older Adults

Hui Chen, Yihong Ding, Klodian Dhana, Puja Agarwal et autres

Importance: Intake of sweetened beverages, including sugar-sweetened beverages (SSB) and artificially sweetened beverages (ASB), has been linked to multiple health outcomes, but their associations with dementia risk among older adults are unclear. Objective: To assess whether the consumption of SSB and ASB …

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Social Engagement, Depressive Symptoms, and Loneliness, and Longitudinal Cognitive Decline in a Population-Based Cohort of Older Adults

Pankaja Desai, Ted Kheng Siang Ng, Kristin R. Krueger, Robert S. Wilson et autres

Objective: The primary objective of this study is to examine the association between social engagement and cognitive decline among participants with and without depressive symptoms and/or loneliness. Methods: Study data is from the Chicago Health and Aging Project (CHAP), a population-based cohort …

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Knowledge, attitude, practices, and perceived barriers towards research among undergraduate medical students in a teaching hospital: A cross-sectional study

Kumar B. Rajan, A Joseph, Prakash AK, Puzhikunnathu VK

Background: In Indian medical colleges, the extensive curriculum often limits undergraduate medical students’ participation in research, coupled with insufficient exposure to research methodologies and time constraints. This study aims to understand the knowledge, attitude, practices, and perceived barriers towards research among the …

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Guidelines for the standardization of pre‐analytical variables for salivary biomarker studies in Alzheimer's disease research: An updated review and consensus of the Salivary Biomarkers for Dementia Research Working Group

Ted Kheng Siang Ng, Chinedu Udeh‐Momoh, Mei‐Ann Lim, Helena Sophia Gleerup et autres

There is a pressing need for accessible biomarkers with high diagnostic accuracy for Alzheimer's disease (AD) diagnosis to facilitate widespread screening, particularly in underserved groups. Saliva is an emerging specimen for measuring AD biomarkers, with distinct contexts of use that could complement …

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Association of subjective memory complaints with serum biomarkers of neurodegeneration and cognition: A population‐based study

Anisa Dhana, Charles DeCarli, Klodian Dhana, Pankaja Desai et autres

Abstract Background Subjective memory complaints (SMCs) refer to memory concerns reported by an individual, regardless of objective test impairment. We conducted a study to evaluate the association of SMCs with serum biomarkers of neurodegeneration, including neurofilament light chain (NfL), glial fibrillary acidic …

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Association of Tailpipe-Related and Nontailpipe–Related Air Pollution Exposure with Cognitive Decline in the Chicago Health and Aging Project

Ryan M. Andrews, Sara D. Adar, Adam A. Szpiro, Joel D. Kaufman et autres

BACKGROUND: Evidence suggests that long-term exposure to air pollution may increase the risk of dementia and related cognitive outcomes. A major source of air pollution is automotive traffic, which is modifiable by technological and regulatory interventions. OBJECTIVES: We examined associations of four …

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