H. de Rooster

Mitochondrial DNA digital PCR improves metastasis quantification in the chick chorioallantoic membrane (CAM) assay

Shari Aerts, Niene Daelman, Gwen Sys, H. de Rooster et autres

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RXRα suppression drives hepatic metabolic and immune dysfunction in sepsis

Matyas Jelinek, Jolien Vandewalle, Marah Heyerick, Tineke Vanderhaeghen et autres

Sepsis is a life-threatening condition in which a dysregulated host response to infection leads to organ dysfunction and metabolic and immune failure. We identify hepatocyte retinoid X receptor α (RXRα) as a key integrator of host resilience during polymicrobial sepsis. RXRα is …

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Evaluation of the Correlation of Arterial and Venous Lactate and Glucose Concentrations in Anesthetized Critically Ill Dogs

Francesca Tirillini, H. de Rooster, Ingeborgh Polis, Nausikaa Devriendt

OBJECTIVE: To investigate the correlation between arterial and venous concentrations of lactate and glucose and to explore the relationship between hyperlactatemia and hyperglycemia in critically ill dogs. DESIGN: Prospective clinical study. SETTING: University veterinary teaching hospital. ANIMALS: Ninety client-owned dogs presenting for …

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Successful long-term patent ductus arteriosus closure in dogs can be achieved with the use of nonabsorbable or absorbable monofilament synthetic sutures

Alexander Schlake, G. Mampaey, Adelina Proteasa, Pascale M. Y. Smets et autres

Objective: To describe the use of synthetic monofilament suture material for closure of left-to-right shunting patent ductus arteriosus (PDA) in dogs, and to compare long-term results between nonabsorbable and slowly absorbable synthetic monofilament suture material with a minimum follow-up of at least …

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Imaging of surgical specimens with the tauCAM: a macroscale fluorescence video system with lifetime imaging capabilities

Thomas Van den Dries, Simone Janssen, Thomas Lapauw, Jeroen De Geeter et autres

Macroscale fluorescence lifetime imaging (MFLI) offers higher sensitivity and specificity for tumor detection than intensity-based imaging, but faces challenges due to low light levels, short lifetimes, and near-infrared (NIR) detection. The tauCAM system provides fluorescence intensity video and on-demand fluorescence lifetime images …

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The lidocaine/monoethylglycinexylidide test is a valuable alternative to protein C activity to determine shunt closure after surgical attenuation of extrahepatic portosystemic shunts in dogs

Nausikaa Devriendt, Greet Junius, Gonçalo Serrano, H. de Rooster

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Klinische studies bij gezelschapsdieren

Laetitia Cicchelero, H. de Rooster

Klinische studies zijn essentieel voor innovatie in (dier)geneeskunde en bieden bijkomende behandelingsopties voor huisdieren. Het is van belang dat dierenartsen en huisdiereigenaars weten wat klinische studies zijn, welke voor- en nadelen ze bieden en waar men terecht kan voor deelname. Dit artikel …

Anatomical variations in the tributaries of the normal feline extrahepatic portal system: evaluation with CT angiography

Nausikaa Devriendt, H. de Rooster, Jimmy H. Saunders, Emmelie Stock

ObjectivesIt is often suggested in the literature that the anatomy of the extrahepatic portal vein (EHPV) in dogs and cats is similar. Nevertheless, variations and contradictions in the tributaries of the EHPV in cats have been described. Therefore, the aim of this …

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Evaluation of soft palate thickness in brachycephalic dogs 3 months after folded flap palatoplasty versus standard staphylectomy

Joep Timmermans, Bart Van Goethem, Emmelie Stock, Tim Bosmans et autres

OBJECTIVE: To evaluate the soft palate thickness in brachycephalic dogs 3 months after performing folded flap palatoplasty (FFP) or standard staphylectomy (STS). STUDY DESIGN: Prospective, observational study. ANIMALS: Twenty client-owned dogs with brachycephalic obstructive airway syndrome undergoing corrective multilevel upper airway surgery. …

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The translational value of comparative oncology trials in client-owned dogs with spontaneous cancer: an overview of clinical trials initiated in dogs that resulted in phase I, II, or III clinical trials in human medicine

Sara Janssen, JJ Lievaart, Laetitia Cicchelero, Anna Krupa et autres

Pet dogs with spontaneous cancer are a relevant translational model for human medicine. Several therapeutics evaluated in canine clinical trials progressed to clinical trials in humans. Promising results from comparative oncology trials in dogs provided good predictions of their safety and efficacy …

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Angiosarcoma: a systematic review of biomarkers in diagnosis, prognosis, and therapeutic strategies

Sofie Vercammen, Ario de Marco, H. de Rooster, Antonio Cosma

Angiosarcoma is a rare, aggressive vascular malignancy characterized by rapid proliferation, early metastasis, and limited therapeutic options, resulting in poor prognosis. The etiopathogenesis of AS remains elusive and diagnosis is challenging due to its similarity to other vascular lesions. This systematic review …

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Prognostic factors for short-term survival of cats that experienced postattenuation neurologic signs after surgical attenuation of single congenital portosystemic shunts

Ignacio Otero Balda, Laura Elizabeth Selmic, Polina Stamenova, Matthew Simpson et autres

Objective: To report 30-day survival of cats that experienced postattenuation neurologic signs (PANS) after surgical attenuation of a single congenital portosystemic shunt (cPSS), and to investigate prognostic factors for short-term survival. Study design: Multi-institutional retrospective study. Sample population: A total of 59 …