Nyam‐Osor Chimge

Targeting Wnt signaling for improved glioma immunotherapy

Margarita Gutova, Jonathan C. Hibbard, Eric Ma, Heini Maaret Natri et autres

Introduction Despite aggressive standard-of-care therapy, including surgery, radiation, and chemotherapy, glioblastoma recurrence is almost inevitable and uniformly lethal. Activation of glioma-intrinsic Wnt/β-catenin signaling is associated with a poor prognosis and the proliferation of glioma stem-like cells, leading to malignant transformation and tumor …

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A Deeply Quiescent Subset of CML LSC depend on FAO yet Avoid Deleterious ROS by Suppressing Mitochondrial Complex I

Nyam‐Osor Chimge, Min-Hsuan Chen, Cu Nguyen, Yuqi Zhao et autres

BACKGROUND AND OBJECTIVE: Disease relapse and therapy resistance remain serious impediments to treating cancer. Leukemia stem cells (LSC) are therapy resistant and the cause of relapse. A state of deep quiescence appears to enable cancer stem cells (CSC) to acquire new somatic …

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Differential Kat3 Coactivator Usage Regulates Brain Metabolism and Neuronal Differentiation

Erasmus Kofi Poku, Masaya Ono, Yusuke Higuchi, Junie Chea et autres

INTRODUCTION: Our previous work has demonstrated significant effects on the oxidative stress response, mitochondrial function, and oxidative phosphorylation in the livers and intestines of p300 S89A knockin (S89AKI) mice. We now show that this mutation is also associated with brain metabolic defects …

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E7386 is not a Specific CBP/β-Catenin Antagonist

Michaël Kahn, Yusuke Higuchi, Cu Nguyen, Nyam‐Osor Chimge et autres

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Supplementary Table 1 from Opposing Effects of Runx2 and Estradiol on Breast Cancer Cell Proliferation: In Vitro Identification of Reciprocally Regulated Gene Signature Related to Clinical Letrozole Responsiveness

Nyam‐Osor Chimge, Sanjeev Kumar Baniwal, Jingqin Rosy Luo, Simon G. Coetzee et autres

PDF file - 174K, Statistical testing of clusters.

Supplementary Table 6 from Opposing Effects of Runx2 and Estradiol on Breast Cancer Cell Proliferation: In Vitro Identification of Reciprocally Regulated Gene Signature Related to Clinical Letrozole Responsiveness

Nyam‐Osor Chimge, Sanjeev Kumar Baniwal, Jingqin Rosy Luo, Simon G. Coetzee et autres

PDF file - 403K, List of genes in Clusters I-IV.

Supplementary Table 3 from Opposing Effects of Runx2 and Estradiol on Breast Cancer Cell Proliferation: In Vitro Identification of Reciprocally Regulated Gene Signature Related to Clinical Letrozole Responsiveness

Nyam‐Osor Chimge, Sanjeev Kumar Baniwal, Jingqin Rosy Luo, Simon G. Coetzee et autres

PDF file - 1.3MB, Complete list of genes interrogated by BeadChip microarrays and fold changes in array comparisons.

Supplementary Figure 1 from Opposing Effects of Runx2 and Estradiol on Breast Cancer Cell Proliferation: In Vitro Identification of Reciprocally Regulated Gene Signature Related to Clinical Letrozole Responsiveness

Nyam‐Osor Chimge, Sanjeev Kumar Baniwal, Jingqin Rosy Luo, Simon G. Coetzee et autres

PDF file - 403K, Cluster IV is linked to the mitotic polo-like kinase pathway. A, The 84 Cluster IV genes were analyzed for pathway enrichment using IPATM. Bars depict significance of enrichment represented by log p values. The line graph shows magnitudes …

Supplementary Materials and Methods from Opposing Effects of Runx2 and Estradiol on Breast Cancer Cell Proliferation: In Vitro Identification of Reciprocally Regulated Gene Signature Related to Clinical Letrozole Responsiveness

Nyam‐Osor Chimge, Sanjeev Kumar Baniwal, Jingqin Rosy Luo, Simon G. Coetzee et autres

PDF file - 59K, Detailed description of the POL and GSE5462 data analyses.

Supplementary Table 2 from Opposing Effects of Runx2 and Estradiol on Breast Cancer Cell Proliferation: In Vitro Identification of Reciprocally Regulated Gene Signature Related to Clinical Letrozole Responsiveness

Nyam‐Osor Chimge, Sanjeev Kumar Baniwal, Jingqin Rosy Luo, Simon G. Coetzee et autres

PDF file - 90K, RT-qPCR primers used in the study.

Supplementary Table 4 from Opposing Effects of Runx2 and Estradiol on Breast Cancer Cell Proliferation: In Vitro Identification of Reciprocally Regulated Gene Signature Related to Clinical Letrozole Responsiveness

Nyam‐Osor Chimge, Sanjeev Kumar Baniwal, Jingqin Rosy Luo, Simon G. Coetzee et autres

PDF file - 19K, Attenuation of responses to E2 by Runx2 and vice versa.

Supplementary Table 7 from Opposing Effects of Runx2 and Estradiol on Breast Cancer Cell Proliferation: In Vitro Identification of Reciprocally Regulated Gene Signature Related to Clinical Letrozole Responsiveness

Nyam‐Osor Chimge, Sanjeev Kumar Baniwal, Jingqin Rosy Luo, Simon G. Coetzee et autres

PDF file - 93K, Validation data.