Lisa Marinelli

Beyond Antibiotics: The Role of Antimicrobial Polymers in Modern Therapeutics

Martina Appignani, Giovanni Corfiati, Lisa Marinelli, Marilisa Pia Dimmito et autres

Antimicrobial polymers are a potential and viable alternative to antibiotic therapies, whose effectiveness is increasingly compromised by the onset of antimicrobial resistance and antibiotic persistence. Antimicrobial polymers also have potential in the formulation of new drug delivery systems. Difficulties in finding new …

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Propolis-loaded solid lipid nanoparticles targeting H. pylori associated with gastro-intestinal diseases

Marilisa Pia Dimmito, Valentina Puca, Antonio Di Stefano, Eleonora Chiara Toto et autres

Propolis is a natural substance rich in polyphenolic and flavonoid compounds, known for its potent antimicrobial and anti-inflammatory properties, particularly effective against pathogens such as Helicobacter pylori ( H. pylori ), which are implicated in the pathogenesis of severe gastric diseases. However, …

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A Methodological Proposal for Health Technology Assessments: A Case Study on Biosimilar Drugs

Marilisa Pia Dimmito, Lisa Marinelli, Eleonora Chiara Toto, Giuseppe Di Biase et autres

This work proposes a methodological approach that could be useful in multidisciplinary health technology assessments (HTAs). Mathematical models based on real data were used to make predictions for the initial price and actual cost of three classes of biological drugs. Through a …

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Synthesis and Characterization of Memantine-Loaded Niosomes for Enhanced Alzheimer’s Disease Targeting

Hasan Türkez, Sena Öner, Özge Çağlar, Mehmet Enes Arslan et autres

Background/Objectives: Over the past 25 years, numerous biological molecules, like recombinant lysosomal enzymes, neurotrophins, receptors, and therapeutic antibodies, have been tested in clinical trials for neurological diseases. However, achieving significant success in clinical applications has remained elusive. A primary challenge has been …

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Estradiol valerate pharmacokinetics in assigned-male-at-birth individuals: implications for gender-affirming care

Jeroen Vervalcke, Lisa Marinelli, Eynde T. Van Den, Jeroen Walravens et autres

Advancements in Inflammatory Bowel Disease Management: From Traditional Treatments to Monoclonal Antibodies and Future Drug Delivery Systems

Annalisa Di Rienzo, Lisa Marinelli, Marilisa Pia Dimmito, Eleonora Chiara Toto et autres

Inflammatory bowel disease (IBD) is a chronic gastrointestinal inflammatory disorder with two main subtypes: ulcerative colitis (UC) and Crohn's disease (CD). The pathogenesis involves genetic predisposition, dysbiosis, and immune dysregulation. Complications include perianal lesions, strictures, fistulas, perforations, and an increased risk of …

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From self-Assembly to healing: Engineering ultra-Small peptides into supramolecular hydrogels for controlled drug release

Marilisa Pia Dimmito, Lisa Marinelli, Ivana Cacciatore, Eleonora Chiara Toto et autres

The aim of this study was the evaluation of suitability of novel mucoadhesive hydrogel platforms for the delivery of therapeutics useful for the management of disorders related to the gastrointestinal tract (GI). At this purpose, here we describe the preparation, the physicochemical …

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Polystyrene nanoplastics mediate oxidative stress, senescence, and apoptosis in a human alveolar epithelial cell line

Cristina Milillo, Eleonora Aruffo, Piero Di Carlo, Antonia Patruno et autres

Background: Nanoplastics, an emerging form of pollution, are easily consumed by organisms and pose a significant threat to biological functions due to their size, expansive surface area, and potent ability to penetrate biological systems. Recent findings indicate an increasing presence of airborne …

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Microbial Infections and Wound Healing: Medicinal-Chemistry and Technological Based Approaches

Ivana Cacciatore, Lisa Marinelli

Microbial infections represent a significant global health challenge that impacts all populations [...].

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Solid lipid nanoparticles for efficient delivery of capsaicin-rich extract: Potential neuroprotective effects in Parkinson’s disease

Lisa Marinelli, Marilisa Pia Dimmito, Ivana Cacciatore, Eleonora Chiara Toto et autres

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In vitro release study of Capsaicin carbopol formulation

Enkelejda Goci, Entela Haloçi, Antonio Di Stefano, Annalisa Chiavaroli et autres

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Self-assembling Peptides (SAPs) as Powerful Tools for the Preparation of Antimicrobial and Wound-Healing Nanostructures

Marilisa Pia Dimmito, Lisa Marinelli, Ivana Cacciatore, Anna Lucia Valeri et autres

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