Exequiel Gonzalo Alonso

Heme oxygenase−1 in thyroid cancer: a context-dependent regulator

Exequiel Gonzalo Alonso, Marilina Mascaró, Karen Schweitzer, Valentina Clemente et autres

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Heme-oxygenase-1: a key player in thyroid carcinoma development

Exequiel Gonzalo Alonso, Marilina Mascaró, Karen Schweitzer, G Giorgi et autres

Abstract: Thyroid cancer is the most prevalent type of endocrine malignancy. Papillary thyroid carcinoma represents the majority of cases and is curable in approximately 90% of them, but it may also progress to anaplastic thyroid cancer, which has a poor prognosis. Therefore, …

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GEF-H1 drives breast cancer cells to tumor progression

Lucía Fernández Chávez, Karen Schweitzer, Exequiel Gonzalo Alonso, María Julia Ferronato et autres

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Dual Faces Of Hemeoxygenase-1 In Breast Cancer: Linking Subcellular Localization To Tumor Behavior And Drug Response

Karen Schweitzer, Exequiel Gonzalo Alonso, G Giorgi, Lucía Fernández Chávez et autres

Introduction: Breast cancer (BC) is a heterogeneous disease and, specifically, triple-negative breast cancer (TNBC) still lacks targeted treatments. Heme oxygenase-1 (HO-1), a stress- response enzyme, exhibits dual roles: the full-length isoform is enzymatically active and often antitumoral, whereas the truncated nuclear form …

Estudio del efecto de las variantes de Hemoxigenasa-1 sobre la progresión del cáncer de mama

Karen Schweitzer, Exequiel Gonzalo Alonso, Lucía Fernández Chávez, Georgina P. Coló et autres

Introducción y antecedentes: La leucemia linfocítica crónica (LLC) es la leucemia más frecuente en adultos de Occidente. El análisis de mutaciones de genes “drivers” resulta de importancia en el establecimiento de grupos de riesgo. El gen NOTCH1 (neurogenic locus notch homolog protein …

Rol del receptor de vitamina D en la respuesta a paclitaxel en cáncer de mama triple negativo

Agustina Ibarra, Valentina Clemente, Karen Schweitzer, Exequiel Gonzalo Alonso et autres

Introducción: El cáncer de mama triple negativo (CMTN) es un subtipo de CM de rápida progresión, alta capacidad metastásica y mal pronóstico, con opciones terapéuticas limitadas por falta de blancos moleculares. El calcitriol, a través del receptor de vitamina D (VDR), posee …

Hemeoxigenase-1 Genetic Variants Effects On Breast Cancer Progression

Karen Schweitzer, Exequiel Gonzalo Alonso, Lucía Fernández Chávez, Georgina P. Coló et autres

Hemoxygenase-1 (HO-1) is a microsomal enzyme that catalyzes the degradation of the heme group (canonical role) and can be cleaved at its C-terminal end, followed by translocation to the nucleus, to perform functions at the transcriptional level (non-canonical role). Our laboratory has …

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Optimising methods for human thyroid primary cell culture isolation

Valentina Arenal, Clara Madsen, Lucía Fernández Chávez, Exequiel Gonzalo Alonso et autres

According to the GLOBOCAN 2020 database on cancer incidence and mortality, thyroid cancer (TC) has the ninth-highest cancer in- cidence worldwide. Basic research contributes to developing diag- nostic and treatment alternatives. Cell models play a crucial role in vitro study of the …

Proteomic analysis of the effect of hemin in breast cancer

Georgina P. Coló, Kelly S. Schweitzer, G.M. Oresti, Exequiel Gonzalo Alonso et autres

Heme, an iron-containing prosthetic group found in many proteins, carries out diverse biological functions such as electron transfer, oxygen storage and enzymatic reactions. Hemin, the oxidised form of heme, is used to treat porphyria and also to activate heme-oxygenase (HO) which catalyses …

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Hemoxygenase-1 Promotes Head and Neck Cancer Cell Viability

Marilina Mascaró, Exequiel Gonzalo Alonso, Karen Schweitzer, Martín Enrique Rabassa et autres

Head and neck squamous cell carcinoma (HNSCC) is a remarkably heterogeneous disease with around 50% mortality, a fact that has prompted researchers to try new approaches to improve patient survival. Hemoxygenase-1 (HO-1) is the rate-limiting step for heme degradation into carbon monoxide, …

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Proteomic analysis of the effect of hemin in breast cancer

Georgina P. Coló, Karen Schweitzer, G.M. Oresti, Exequiel Gonzalo Alonso et autres

Abstract Heme, an iron-containing prosthetic group found in many proteins, carries out diverse biological functions such as electron transfer, oxygen storage and enzymatic reactions. Hemin, the oxidised form of heme, is used to treat porphyria and also to activate heme-oxygenase (HO) which …

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Role of SPARC in the epithelial-mesenchymal transition induced by PTHrP in human colon cancer cells

Pedro Carriere, Natalia Calvo, María Belén Novoa Díaz, Fernanda López‐Moncada et autres

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