Delbert G. Gillespie

Effects and Mechanism of 2′-AMP on Renal Vascular Resistance

Edwin K. Jackson, Dongmei Cheng, Delbert G. Gillespie, Zaichuan Mi et autres

KEY POINTS: 2'-AMP is endogenous and causes renal vasoconstriction in part by allosteric modulation of P2X1 receptors that enhances ATP-induced opening of P2X1 receptor channels. Kidney tissue nonspecific alkaline phosphatase (TNAP) by metabolizing 2'-AMP protects against 2'-AMP-induced renal vasoconstriction, a protection lost …

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8-Aminoguanine and its actions in the metabolic syndrome

Edwin K. Jackson, Delbert G. Gillespie, Zaichuan Mi, Lori A. Birder et autres

The metabolic syndrome is characterized by obesity, insulin resistance, dyslipidemia and hypertension and predisposes to cardiorenal injury. Here, we tested our hypothesis that 8-aminoguanine, an endogenous purine, exerts beneficial effects in Zucker Diabetic-Sprague Dawley (ZDSD) rats, a preclinical model of the metabolic …

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Attenuation of HIV-specific T cell responses Among people with HIV on ART following dipyridamole treatment

Benjamin C Morris, Emily A Hixson, Cynthia Klamar-Blain, Delbert G. Gillespie et autres

Twelve weeks of dipyridamole increased extracellular adenosine levels and decreased T cell activation in people with human immunodeficiency virus (HIV). In this analysis, we investigated the effect of dipyridamole on HIV-specific T cell responses. We compared changes in Gag- and Env-specific T …

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8-Aminoguanine and Its Actions on Renal Excretory Function

Edwin K. Jackson, Delbert G. Gillespie, Zaichuan Mi

Background: The endogenous purine 8-aminoguanine induces diuresis/natriuresis/glucosuria by inhibiting PNPase (purine nucleoside phosphorylase); however, mechanistic details are unknown. Methods: Here, we further explored in rats 8-aminoguanine’s effects on renal excretory function by combining studies using intravenous 8-aminoguanine, intrarenal artery infusions of PNPase …

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Biochemical pathways of 8-aminoguanine production in Sprague-Dawley and Dahl salt-sensitive rats

Edwin K. Jackson, Elizabeth V. Menshikova, Vladimir B. Ritov, Delbert G. Gillespie et autres

BACKGROUND: 8-Aminoguanine exerts natriuretic and antihypertensive activity. Whether and how "free" 8-aminoguanine exists in vivo is unclear. Because 8-nitroguanosine is naturally occurring, we tested the hypothesis that 8-aminoguanine can arise from: pathway 1, 8-nitroguanosine → 8-aminoguanosine → 8-aminoguanine; and pathway 2, 8-nitroguanosine …

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Long‐Term Dipeptidyl Peptidase 4 Inhibition Worsens Hypertension and Renal and Cardiac Abnormalities in Obese Spontaneously Hypertensive Heart Failure Rats

Edwin K. Jackson, Zaichuan Mi, Delbert G. Gillespie, Dongmei Cheng et autres

Background The long‐term effects of dipeptidyl peptidase 4 (DPP4) inhibitors on blood pressure and cardiovascular and renal health remain controversial. Herein, we investigated the extended (>182 days) effects of DPP4 inhibition in a model of spontaneous hypertension, heart failure, diabetes mellitus, obesity …

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Brief Report: Dipyridamole Decreases Gut Mucosal Regulatory T-Cell Frequencies Among People With HIV on Antiretroviral Therapy

Christina Mallarino-Haeger, Kaleab Z. Abebe, Edwin K. Jackson, Ashley Zyhowski et autres

BACKGROUND: We had previously conducted a double-blind, randomized placebo-controlled, partial cross-over trial showing that 12 weeks of dipyridamole decreased CD8 T-cell activation among treated HIV(+) individuals by increasing extracellular adenosine levels. METHODS: In this substudy, rectosigmoid biopsies were obtained from 18 participants …

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Author Correction: Simultaneous Inhibition of Glycolysis and Oxidative Phosphorylation Triggers a Multi-Fold Increase in Secretion of Exosomes: Possible Role of 2′,3′-cAMP

Nils Ludwig, Saigopalakrishna S. Yerneni, Elizabeth V. Menshikova, Delbert G. Gillespie et autres

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Purine Metabolites in Tumor-Derived Exosomes May Facilitate Immune Escape of Head and Neck Squamous Cell Carcinoma

Nils Ludwig, Delbert G. Gillespie, Torsten E. Reichert, Edwin K. Jackson et autres

Body fluids of patients with head and neck squamous cell carcinoma (HNSCC) are enriched in exosomes that reflect properties of the tumor. The aim of this study was to determine whether purine metabolites are carried by exosomes and evaluate their role as …

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Adenosine receptors regulate exosome production

Nils Ludwig, Juliana H. Azambuja, Aparna Rao, Delbert G. Gillespie et autres

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Tumor-derived exosomes promote angiogenesis via adenosine A2B receptor signaling

Nils Ludwig, Saigopalakrishna S. Yerneni, Juliana H. Azambuja, Delbert G. Gillespie et autres

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Characterization of the N6-etheno-bridge method to assess extracellular metabolism of adenine nucleotides: detection of a possible role for purine nucleoside phosphorylase in adenosine metabolism

Edwin K. Jackson, Delbert G. Gillespie, Dongmei Cheng, Zaichuan Mi et autres

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