Shinji Kuriki

Proteomic Analysis of Serum Extracellular Vesicles Revealed Fibulin‐3 as a Novel Predictive Biomarker for Hepatocellular Carcinoma in Patients With Chronic Hepatitis B

Emi Sometani, Kazuhiro Murai, Hayato Hikita, Jihyun Sung et autres

BACKGROUND AND AIM: Although nucleos(t)ide analog (NUC) therapy reduces hepatocellular carcinoma (HCC) incidence in chronic hepatitis B (CHB) patients, HCC can develop despite viral suppression. Identifying predictive biomarkers of HCC during NUC therapy remains clinically important. This study aimed to identify novel …

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Auranofin, identified by FDA-approved drug library screening, inhibits HBs antigen secretion via lysosomal damage

Akiyoshi Shimoda, Kazuhiro Murai, Hayato Hikita, Satoshi Minami et autres

BACKGROUND AND AIM: Hepatitis B surface antigen (HBsAg) is associated with hepatocellular carcinoma risk and immune exhaustion and contributes to hepatitis B virus (HBV) persistence. Current anti-HBV treatments have a limited ability to reduce HBsAg levels. This study aimed to identify FDA-approved …

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The Risk of Developing Hepatocellular Carcinoma Persists in Chronic Hepatitis B Patients Even After the Long‐Term Administration of Nucleos(t)ide Analogs

Kazuhiro Murai, Hayato Hikita, Ryoko Yamada, Yuki Nishimura et autres

BACKGROUND AND AIM: Nucleos(t)ide analogs (NUCs) are used in the treatment of chronic hepatitis B (CHB). It is still uncertain whether the risk of incident hepatocellular carcinoma (HCC) continues beyond 5 or 10 years after the initiation of NUC treatment. We aimed …

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Endoscopic submucosal dissection for early gastric cancer in a patient after left ventricular assist device implantation: A case report

Shinji Kuriki, Yoshiki Tsujii, Hirotsugu Saiki, Takahiro Amano et autres

The use of left ventricular assist device (LVAD) implantation has increased in recent years. Here, we report the first case of gastric endoscopic submucosal dissection (ESD) following LVAD implantation. A 69-year-old man who previously underwent LVAD implantation for severe heart failure underwent …

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Similar impressions of humanness for human and artificial singing voices in autism spectrum disorders

Shinji Kuriki, Yuri Tamura, Miki Igarashi, Nobumasa Kato et autres

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Involvement of the left insula in the ecological validity of the human voice

Yuri Tamura, Shinji Kuriki, Tamami Nakano

A subtle difference between a real human and an artificial object that resembles a human evokes an impression of a large qualitative difference between them. This suggests the existence of a neural mechanism that processes the sense of humanness. To examine the …

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