Paul Myoung

Reply: Estimating the cost of liver transplantation

Alyson J. Kaplan, Sharon E. Klarman, Adam Winters, Michael S. Kriss et autres

We thank Drs Lankarani and Lankarani for their thoughtful correspondence regarding our recent review on the rising cost of liver transplantation (LT) in the United States. Their comments highlight meaningful dimensions of transplant economics, including system-level perspectives, equity considerations, and international experiences. …

us (code pays fourni par la source)

The rising cost of liver transplantation in the United States

Alyson J. Kaplan, Adam C. Winters, Sharon E. Klarman, Michael S. Kriss et autres

Liver transplantation (LT) is the only curative treatment for end-stage liver disease and significantly improves patient outcomes. However, LT is resource-intensive and costly, with expenditures rising dramatically in recent years. Factors contributing to this increase in cost include expanded transplant criteria, utilization …

us (code pays fourni par la source)

Sa1535 IMPLEMENTATION OF HCV+ DONOR HEART PROTOCOL PRODUCES NET OVERALL COST SAVINGS IN CARDIAC TRANSPLANTATION

Thomas J. Wang, Xing Li, Emily D. Bethea, Paul Myoung et autres

Immediate administration of antiviral therapy after transplantation of hepatitis C-infected livers into uninfected recipients: Implications for therapeutic planning

Emily D. Bethea, Ashwini Arvind, Jenna L. Gustafson, Karin L. Andersson et autres

The practice of transplanting hepatitis C (HCV)-infected livers into HCV-uninfected recipients has not previously been recommended in transplant guidelines, in part because of concerns over uncontrolled HCV infection of the allograft. Direct-acting antivirals (DAAs) provide an opportunity to treat donor-derived HCV-infection and …

us (code pays fourni par la source)

Pre-emptive pangenotypic direct acting antiviral therapy in donor HCV-positive to recipient HCV-negative heart transplantation: an open-label study

Emily D. Bethea, Kerry Gaj, Jenna L. Gustafson, Andrea L. Axtell et autres

us (code pays fourni par la source)

Factors Associated with Failure to List HIV-Positive Kidney Transplant Candidates

Deirdre L. Sawinski, Christina M. Wyatt, L Casagrande, Paul Myoung et autres

With improved survival in the antiretroviral era, data from ongoing studies suggest that HIV patients can be safely transplanted. The disproportionate burden of HIV-related end-stage renal disease in minority populations may impose additional obstacles to successful completion of the transplant evaluation. We …

us (code pays fourni par la source)

Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease.

Lisa Mosconi, Sandro Sorbi, Mony J. de Leon, Yi Li et autres

UNLABELLED: The aim of the present study is to compare brain atrophy with hypometabolism as preclinical markers of Alzheimer's disease (AD) by studying presymptomatic individuals from families with known early-onset autosomal dominant AD (FAD) carrying mutations in the Presenilin 1 gene. METHODS: …

us (code pays fourni par la source)

P2–314: Hypometabolism precedes volume loss in presymptomatic individuals with early–onset familial Alzheimer's disease

Lisa Mosconi, Alberto Pupi, Mony J. de Leon, Yi Jie Li et autres

The aim of the present study is to compare brain atrophy to hypometabolism as preclinical markers of AD by studying presymptomatic individuals from families with early–onset autosomal dominant AD (FAD) carrying mutations in the Presinilin–1 gene. FAD individuals near to the anticipated …

us, it (code pays fourni par la source)

Subsets of ambulatory myocardial ischemia based on heart rate activity. Circadian distribution and response to anti-ischemic medication. The Angina and Silent Ischemia Study Group (ASIS)

T CAndrews, TFenton, NToyosaki, S PGlasser et autres

BACKGROUNDIdentification of whether episodes of ambulatory ischemia are caused by increases in myocardial oxygen demand or to episodic coronary vasoconstriction in patients with stable coronary disease may be important to guide selection of optimal anti-ischemic therapy and to gain insight into mechanisms …

Risk stratification of patients with non-Q wave myocardial infarction. The critical role of ST segment depression. The Diltiazem Reinfarction Study Research Group.

K BSchechtman, R JCapone, R EKleiger, R SGibson et autres

One-year follow-up data on 515 patients who survived hospitalization with MB-creatine kinase-confirmed, acute non-Q wave myocardial infarction were analyzed for factors related to mortality (n = 57) and late reinfarction (n = 64). Twelve of 24 analyzed variables were significantly associated with …

Beneficial effects of high-dose diltiazem in patients with persistent effort angina on beta-blockers and nitrates: a randomized, double-blind, placebo-controlled cross-over study.

W EBoden, E WBough, M JReichman, V BRich et autres

The effects of orally administered diltiazem combined with maximally tolerated doses of beta-blockers and nitrates were assessed in 12 patients, who during stress testing exhibited persistent effort angina and continued objective evidence for inducible myocardial ischemia. Patients performed multistage semisupine exercise on …