Brett A. Wagner

EQual Rubric Evaluation of the Radiation Oncology Education Collaborative Study Group Entrustable Professional Activities

Brett A. Wagner, S.E. Braunstein, Ryan J. Brisson, Alexandra N. De Leo et autres

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Characterizing the Clinical Role of Radiation Oncology Advanced Practice Providers Using Clinical Entrustable Professional Activities

Brett A. Wagner, Levi Martinka, Sarah Anderson, Katherine Bukolt et autres

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EQual Rubric Evaluation of the Radiation Oncology Education Collaborative Study Group Entrustable Professional Activities

Brett A. Wagner, Steve Braunstein, Ryan J. Brisson, Alexandra De Leo et autres

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Body composition and allostatic load in racially and ethnically diverse patients with metastatic colorectal cancer.

Brett A. Wagner, Yaroslava Bogdan, Victoria Gómez, Pokhraj P Suthar et autres

e15598 Background: Patients with metastatic colorectal cancer (mCRC) are living longer due to treatment advances; however, adverse phenotypes of body composition (BC) such as sarcopenia (SA) and myosteatosis are associated with lower survival. Allostatic load (AL), a measure of physiological stress, and …

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Carbon Monoxide Stimulates Chondrocyte Mitochondria and Protects Mitochondria During Cartilage Injury

Suryamin Liman, Madeline Hines, Piedad C. Gómez-Contreras, Emily Witt et autres

Objective: Joint injury precipitates post-traumatic osteoarthritis (PTOA) via chondrocyte mitochondrial oxidative damage. Carbon monoxide (CO) is a small molecule with potent antioxidant and mitochondrial benefits in other tissues that have not been explored in healthy chondrocytes. We hypothesized that CO would subvert …

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Pharmacological ascorbate combined with rucosopasem selectively radio-chemo-sensitizes NSCLC via generation of H2O2

Casey Pulliam, Melissa A. Fath, Sho S, Susan T. Johnson et autres

production.

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A randomized trial of pharmacological ascorbate, gemcitabine, and nab-paclitaxel for metastatic pancreatic cancer

Kellie L. Bodeker, Daniel Berg, Chandrikha Chandrasekharan, Saima Sharif et autres

Patients with metastatic pancreatic ductal adenocarcinoma (PDAC) have poor 5-year survival. Pharmacological ascorbate (P-AscH - , high dose, intravenous, vitamin C) has shown promise as an adjunct to chemotherapy. We hypothesized adding P-AscH - to gemcitabine and nab -paclitaxel would increase survival …

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A reciprocal relationship between mitochondria and lipid peroxidation determines the chondrocyte intracellular redox environment

Madeline Hines, Piedad C. Gómez-Contreras, Suryamin Liman, Alexandria M. Wilson et autres

In orthopedic research, many studies have applied vitamin E as a protective antioxidant or used tert-butyl hydroperoxide to induce oxidative injury to chondrocytes. These studies often support the hypothesis that joint pathology causes oxidative stress and increased lipid peroxidation that might be …

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Mitochondrial uncoupling proteins protect human airway epithelial ciliated cells from oxidative damage

Akansha Jain, Bo Ram Kim, Wenjie Yu, Thomas O. Moninger et autres

Apical cilia on epithelial cells defend the lung by propelling pathogens and particulates out of the respiratory airways. Ciliated cells produce ATP that powers cilia beating by densely grouping mitochondria just beneath the apical membrane. However, this efficient localization comes at a …

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Figure S1 from Magnetic Resonance Imaging of Iron Metabolism with T2* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM

Michael S. Petronek, Varun Monga, Kellie L. Bodeker, Michael Kwofie et autres

T2* relaxation in GBM and normal tissue.

Figure S6 from Magnetic Resonance Imaging of Iron Metabolism with T2* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM

Michael S. Petronek, Varun Monga, Kellie L. Bodeker, Michael Kwofie et autres

Ferritin overexpression-induced Fe metabolic perturbations.

Table S1 from Magnetic Resonance Imaging of Iron Metabolism with T2* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM

Michael S. Petronek, Varun Monga, Kellie L. Bodeker, Michael Kwofie et autres

Study Representativeness Table