Yansha Meng

Antimicrobial peptide-derived lipid nanoparticles enable lung-targeted mRNA therapy for multidrug-resistant bacterial pneumonia

Xucheng Hou, Shi Du, Wenxi Zhang, Wenkai Zhou et autres

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Multi-omics analysis to reveal the synergistic mechanism underlying the multiple ingredients of Stephania tetrandra extract on rheumatoid arthritis through the PI3K/Akt signaling pathway

Jinfeng Chen, An Zhang, Anzheng Nie, Xiaoxiao Zuo et autres

Background: Stephania tetrandra has been used for treating rheumatic diseases for thousands of years in rural areas of China. Several studies have found that tetrandrine and fangchinoline can inactivate the PI3K/Akt signaling pathway by reducing the expression and phosphorylation of AKT. However, …

cn (code pays fourni par la source)

A New Anti‐Immune Evasion Strategy against Methicillin‐Resistant Staphylococcus Aureus (MRSA) Infections: Simulating Complement Immunotherapy Based on Complement‐Mimic Antibiotic Delivery System

Xucheng Hou, Wenxi Zhang, Yansha Meng, Wenkai Zhou et autres

Abstract Methicillin‐resistant Staphylococcus aureus (MRSA) can interfere with synergistic host defenses, thus escaping from immune surveillance. Herein, a new immunotherapy strategy‐simulating complement therapy is proposed. Two artificial effectors, Tat cell penetrating peptide and wheat germ agglutinin, are utilized to develop a multifunctional …

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Multi-functional Liposomes Enhancing Target and Antibacterial Immunity for Antimicrobial and Anti-Biofilm Against Methicillin-Resistant Staphylococcus aureus

Yansha Meng, Xucheng Hou, Jiongxi Lei, Mengmeng Chen et autres

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Sirolimus-loaded polymeric micelles with honokiol for oral delivery

Xinru Li, Xucheng Hou, Weiming Ding, Shuangchen Cong et autres

OBJECTIVES: The aims of the present study were to design polymeric micelles loading sirolimus with honokiol to increase drug solubility and to gain an insight into the effect of honokiol on oral transport of P-glycoprotein substrate (P-gp). METHODS: Particle size distribution, encapsulation …

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Co-delivery of honokiol, a constituent of Magnolia species, in a self-microemulsifying drug delivery system for improved oral transport of lipophilic sirolimus

Weiming Ding, Xucheng Hou, Shuangchen Cong, Yuanyuan Zhang et autres

Sirolimus is recognized as a P-glycoprotein (P-gp) substrate with poor water-solubility. To improve its solubility and bioabsorption, self-microemulsifying drug delivery systems (SMEDDS) containing a novel P-gp inhibitor, honokiol, were prepared. The aim of this work was to evaluate the enhanced transport of …

cn (code pays fourni par la source)