Bizhan Aarabi

The sodium-glutamate antagonist riluzole improves outcome after acute spinal cord injury: results from the RISCIS randomised controlled trial analysed using a global statistical analytic technique

Michael George Fehlings, Karlo Miguel Pedro, Mohammed Ali Alvi, Ali Moghaddamjou et autres

BACKGROUND: Spinal cord injury (SCI) clinical trials typically rely on a single primary endpoint to assess drug efficacy. This strategy fails to adequately capture the full impact of treatment in heterogenous neurological conditions like SCI. A more patient-centric analysis requires assessment of …

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Traumatic bilateral deep cerebral venous thrombosis: illustrative case

Callum D. Dewar, Maureen Scarboro, Cara Diaz Lomangino, Gary Schwartzbauer et autres

BACKGROUND: Deep cerebral venous thrombosis (DCVT) is exceedingly rare in isolation in the setting of trauma. Repercussions from delayed or absent treatment are associated with permanent neurological deficits and high rates of mortality. OBSERVATIONS: A 19-year-old male presented with headache and lethargy …

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AO Spine Clinical Practice Recommendations for the Surgical Management of Acute Traumatic Spinal Cord Injury: Contemporary Concepts

Vanessa Hubertus, Jetan H. Badhiwala, Nader Hejrati, Aria Nouri et autres

Study DesignReview of the literature with critical appraisal and clinical recommendations.ObjectiveTo highlight contemporary concepts relating to surgical care for acute traumatic spinal cord injury (SCI) based on recent evidence that may be integrated into clinical practice.MethodsThree recent articles relating to the surgical …

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Reduction of traumatic unilateral locked facet of the subaxial cervical spine: what predicts successful closed skeletal traction, and is anterior or posterior surgery superior after unsuccessful closed reduction?

Bradley E. Wilhelmy, Riccardo Serra, Parantap D. Patel, Jesse A. Stokum et autres

OBJECTIVE: Closed skeletal traction (CST) to reduce unilateral locked facets in the subaxial cervical spine can expedite spinal realignment prior to definitive surgery but is not always successful. What predicts successful closed reduction is not completely understood. In addition, whether open anterior …

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The feasibility and utility of intraoperative ultrasound in spinal cord injury patients: an international survey of AO spine members

Chris J. Neal, Olesja Hazenbiller, Christoph Paul Hofstetter, Bizhan Aarabi et autres

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Mechanisms of Traumatic Spinal Cord Injury AIS Grade Conversion

Jesse A. Stokum, Riccardo Serra, Nicole Gorny, Bradley E. Wilhelmy et autres

Spinal cord injury (SCI) remains a major unsolved problem that permanently impairs the lives of innumerable individuals worldwide. Although advances in the basic, pre-clinical and clinical sciences of SCI hold promise for patients, clinicians may lack a full insight into the relevant …

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Technical report: clinical feasibility of augmented reality-navigated chronic subdural hematoma evacuation

Joshua Robert Olexa, Annie Trang, Timothy J. Chryssikos, Gary Schwartzbauer et autres

Management of chronic subdural hematoma (cSDH) poses unique challenges and can be fraught with complications. Understanding the spatial relationships of cSDH to adjacent brain tissue and skull topography is critical for successful surgical treatment. The aim of this report is to highlight …

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Technical report: Clinical feasibility of augmented reality-navigated chronic subdural hematoma evacuation

Joshua Robert Olexa, Annie Trang, Timothy J. Chryssikos, Gary Schwartzbauer et autres

Chronic subdural hematoma is an increasingly common pathology for neurosurgeons. Management of chronic Subdural Hematoma (cSDH) poses unique challenges and can be fraught with potential complications. Understanding the spatial relationships of cSDH to adjacent brain tissue and skull topography is critical for …

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Early management of adult traumatic spinal cord injury in patients with polytrauma: a consensus and clinical recommendations jointly developed by the World Society of Emergency Surgery (WSES) & the European Association of Neurosurgical Societies (EANS)

Edoardo Picetti, Andreas Kyriacou Demetriades, Fausto Catena, Bizhan Aarabi et autres

BACKGROUND: The early management of polytrauma patients with traumatic spinal cord injury (tSCI) is a major challenge. Sparse data is available to provide optimal care in this scenario and worldwide variability in clinical practice has been documented in recent studies. METHODS: A …

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Trends in the Use of Corticosteroids in the Management of Acute Spinal Cord Injury in North American Clinical Trials Network Sites

Nader Hejrati, Bizhan Aarabi, Chris J. Neal, Beatrice Ugiliweneza et autres

Immunomodulatory therapeutics represent a potential neuroprotective strategy for the management of acute spinal cord injury (SCI). One of the most intensely debated neuroprotective drugs has been methylprednisolone sodium succinate (MPSS), which was investigated initially for its role in mitigating lipid peroxidation. More …

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Evolving Profile of Acute Spinal Cord Injury Demographics, Outcomes, and Surgical Treatment in North America: Analysis of a Prospective Multi-Center Dataset of 989 Patients

Aditya Vedantam, Beatrice Ugiliweneza, Theresa L. Williamson, James David Guest et autres

Changes in demography and injury patterns have altered the profile and outcome of acute spinal cord injury (SCI) over time. This study sought to describe recent trends in epidemiology and early clinical outcomes using the multi-center North American Clinical Trial Network (NACTN) …

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Trajectory-Based Classification of Recovery in Sensorimotor Complete Traumatic Cervical Spinal Cord Injury

Blessing N. R. Jaja, Jetan H. Badhiwala, James David Guest, James Shields Harrop et autres

OBJECTIVE: To test the hypothesis that sensorimotor complete traumatic cervical spinal cord injury (SCI) is a heterogenous clinical entity comprising several subpopulations that follow fundamentally different trajectories of neurologic recovery. METHODS: We analyzed demographic and injury data from 655 patients who were …

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