Accès ouvert
2026
article
OpenAlex
Vanessa Rebecca Gasparini, Silvia Orsi, Alessia Buratin, Elisa Rampazzo et autres
Background/Objectives: Identifying molecular liabilities and understanding disease heterogeneity are prerequisites for advancing therapies in T-cell prolymphocytic leukemia (T-PLL), a rare T-cell malignancy with a poor prognosis. Methods: RNA-seq profiling of T-PLL samples (n = 10) and the normal counterpart (n = 5) …
it
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Accès ouvert
2026
article
OpenAlex
Maria Castronuovo, Guido Capasso, Allison Beltrame, Nayla Mouawad et autres
Additional file 1: Supplementary Methods, Figures S1-S6, and Tables S1-S2.
it
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Accès ouvert
2026
article
OpenAlex
Maria Castronuovo, Guido Capasso, Allison Beltrame, Nayla Mouawad et autres
Additional file 1: Supplementary Methods, Figures S1-S6, and Tables S1-S2.
it
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Accès ouvert
2025
conference-abstract
OpenAlex
Antonella Teramo, Elisa Rampazzo, Eleonora Roncaglia, Barbara Mariotti et autres
Abstract INTRODUCTION T-Large Granular Lymphocyte Leukemia (T-LGLL) is a rare lymphoproliferative disorder characterized by the clonal expansion of cytotoxic LGLs. The disease exhibits significant heterogeneity, with clinical manifestations ranging from indolent to life-threatening conditions. T-LGL lymphoproliferation is driven by both somatic gain-of-function …
it
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Accès ouvert
2025
article
OpenAlex
Giulia Calabretto, Andrea Binatti, Antonella Teramo, Alessia Buratin et autres
The biological basis of the high clinical heterogeneity of T-LGL Leukemia (T-LGLL) is not completely understood and effective therapies for this disease are lacking. Through RNA-Sequencing of purified T-LGLs we reveal gene expression profiles and pathway dysregulations in the major patient subgroups, …
it
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Accès ouvert
2024
article
OpenAlex
Vanessa Rebecca Gasparini, Elisa Rampazzo, Gregorio Barilà, Alessia Buratin et autres
Finding an effective treatment for T-PLL patients remains a significant challenge. Alemtuzumab, currently the gold standard, is insufficient in managing the aggressiveness of the disease in the long term. Consequently, numerous efforts are underway to address this unmet clinical need. The rarity …
it
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Accès ouvert
2024
article
OpenAlex
Benedetta Kassabian, Monica Facco, Alessandro Miscioscia, Samuela Carraro et autres
Blood-brain barrier dysfunction might be driven by peripheral inflammation. TNFα inhibitors (TNF-αi) are occasionally associated with a wide spectrum of neurological immuno-mediated disorders. However, patients with systemic autoimmune disorders, including rheumatoid arthritis (RA), might be prone to develop further organ-specific, including central …
it
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Accès ouvert
2024
article
OpenAlex
Francesco Angotzi, Alessandro Cellini, Valeria Ruocco, Chiara Adele Cavarretta et autres
Chronic lymphocytic leukemia (CLL) exhibits substantial variability in disease course. The mutational status of the B-cell receptor immunoglobulin heavy variable (IGHV) chain is a critical prognostic factor, categorizing patients into mutated (M-IGHV) and unmutated (U-IGHV) groups. Recently, a third subgroup with borderline …
it
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2023
conference-abstract
OpenAlex
Andrea Visentin, Enrico Gaffo, Moritz Fürstenau, Jennifer A. Woyach et autres
Introduction Rearrangements of the BCL3 gene due to the translocation t(14;19)(q32;q13) can be identified in up to 1% of chronic lymphocytic leukemias (CLL) with stimulated karyotype and is associated with an adverse outcome. In this study, we aimed at unraveling the clinico-molecular …
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Accès ouvert
2023
article
OpenAlex
Filippo Severin, Nayla Mouawad, Edoardo Ruggeri, Andrea Visentin et autres
Summary Signalling events downstream the B‐cell receptor (BCR) are central for the survival and progression of chronic lymphocytic leukaemia (CLL) cells. Focal adhesion kinase (FAK), regulated through calpain, interacts with molecules of BCR signalling, cytoskeletal modelling and disease progression, such as Src/Lyn, …
it
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Accès ouvert
2023
article
OpenAlex
Cristina Vicenzetto, Vanessa Rebecca Gasparini, Gregorio Barilà, Antonella Teramo et autres
T-cell large granular lymphocyte leukemia (T-LGLL) is a chronic lymphoproliferative disorder characterized by the clonal expansion of T-cell large granular lymphocytes (T-LGL). Immunophenotypic and genotypic features contribute to discriminate symptomatic (CD8+ STAT3-mutated T-LGLL) from clinically indolent patients, this latter group including CD8+ …
it
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2023
article
OpenAlex
Annalisa Martines, Angela Grassi, Andrea Visentin, Monica Facco et autres
The peer review history for this article is available at https://www.webofscience.com/api/gateway/wos/peer-review/10.1002/hon.3201. The data that support the findings of this study are available from the corresponding author upon reasonable request. Please note: The publisher is not responsible for the content or functionality of …
it
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