Aernoud van Batenburg

Access to lymphangioleiomyomatosis care across Europe: an ERN-LUNG survey of clinical practice, and the case for a European registry and trial network

Donal O'Malley, Elisabeth Humbert-Dorfmüller, Joan Albert Barberà, Aernoud van Batenburg et autres

A European LAM Registry would enable standardised data collection, support clinical research and facilitate transnational collaboration, establishing an optimal platform for advancing care and developing a coordinated trial network https://bit.ly/4no2xlr.

Pulmonary fibrosis in non-mutation carriers of families with short telomere syndrome gene mutations

Annette Van Der Vis, Jasper van der Smagt, Aernoud van Batenburg, Wouter van Es et autres

Germline mutations in telomere related genes (TRG) can lead to telomere shortening and are associated with short telomere syndromes (STS). Telomere length is heritable, and progeny of TRG mutation carriers are known to have shorter telomeres. In families with TRG mutations, genetic …

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Telomere shortening in type II pneumocytes relates to fibrotic areas in idiopathic pulmonary fibrosis and has a detrimental effect on survival

Aernoud van Batenburg

Telomere shortening in type II pneumocytes relates to idiopathic pulmonary fibrosis

Aernoud van Batenburg, Reinier Snetselaar, Roel Goldschmeding, Jan C. Grutters et autres

Background: Idiopathic Pulmonary Fibrosis (IPF) is a devastating disease with a median post-diagnostic survival of approximately 4 years. Recently it has been discovered that telomere length (TL) maintenance plays a key role in IPF. In patients with different types of pulmonary fibrosis, …

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Fourth-Generation Epac-Based FRET Sensors for cAMP Feature Exceptional Brightness, Photostability and Dynamic Range: Characterization of Dedicated Sensors for FLIM, for Ratiometry and with High Affinity

Jeffrey B. Klarenbeek, Joachim Goedhart, Aernoud van Batenburg, Daniella Groenewald et autres

Epac-based FRET sensors have been widely used for the detection of cAMP concentrations in living cells. Originally developed by us as well as others, we have since then reported several important optimizations that make these sensors favourite among many cell biologists. We …

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