Carey R. Petrie

Dose-Response of a Norovirus GII.2 Controlled Human Challenge Model Inoculum

Nadine Rouphael, Allison Beck, Amy Kirby, Pengbo Liu et autres

BACKGROUND: Genogroup II noroviruses are the most common cause of acute infectious gastroenteritis. We evaluated the use of a new GII.2 inoculum in a human challenge. METHODS: Forty-four healthy adults (36 secretor-positive and 8 secretor-negative for histo-blood group antigens) were challenged with …

us (code pays fourni par la source)

Safety and immunogenicity of three seasonal inactivated influenza vaccines among pregnant women and antibody persistence in their infants

Flor M. Muñoz, Shital M. Patel, Lisa A. Jackson, Geeta K. Swamy et autres

us (code pays fourni par la source)

Safety and immunogenicity of seasonal trivalent inactivated influenza vaccines in pregnant women

Flor M. Muñoz, Lisa A. Jackson, Geeta K. Swamy, Kathryn M. Edwards et autres

us (code pays fourni par la source)

The Sierra Leone Trial to Introduce a Vaccine Against Ebola: An Evaluation of rVSV∆G-ZEBOV-GP Vaccine Tolerability and Safety During the West Africa Ebola Outbreak

Mohamed Samai, Jane F. Seward, Susan T. Goldstein, Barbara E. Mahon et autres

The West Africa Ebola epidemic stimulated rapid implementation of Ebola vaccine trials in the 3 highly affected countries. In Sierra Leone, we studied the recombinant vesicular stomatitis virus Ebola vaccine (rVSV∆G-ZEBOV-GP) safety and efficacy. The Sierra Leone Trial to Introduce a Vaccine …

Sierra Leone, us (code pays fourni par la source)

Participant Retention in a Randomized Clinical Trial in an Outbreak Setting: Lessons From the Sierra Leone Trial to Introduce a Vaccine Against Ebola (STRIVE)

Rosalind J. Carter, Reynold G. B. Senesi, Peter Dawson, Ibrahim J. Gassama et autres

The Sierra Leone Trial to Introduce a Vaccine Against Ebola (STRIVE), a phase 2/3 trial of an investigational Ebola vaccine, was implemented in April 2015 in Sierra Leone. Healthcare and Ebola frontline workers were randomized to immediate (within 7 days) or deferred …

us, Sierra Leone (code pays fourni par la source)

Clinical Surveillance and Evaluation of Suspected Ebola Cases in a Vaccine Trial During an Ebola Epidemic: The Sierra Leone Trial to Introduce a Vaccine Against Ebola

M Conteh, Susan T. Goldstein, Haja Wurie, Jane Gidudu et autres

Abstract The Sierra Leone Trial to Introduce a Vaccine Against Ebola (STRIVE), an Ebola vaccine trial conducted during the 2014–2016 Ebola epidemic, coordinated with the Sierra Leone national response to identify Ebola cases among trial participants. The early symptoms of Ebola are …

Sierra Leone, us (code pays fourni par la source)

Transcriptome Analysis in Human Breast Milk and Blood after Inactivated or Attenuated Influenza Immunization

Elizabeth P. Schlaudecker, Johannes B. Goll, Travis L. Jensen, Carey R. Petrie et autres

The goal of this study was to identify transcriptomic signatures (RNA-Seq) in human peripheral blood mononuclear cells (PBMCs) and breast milk lymphocyte cells (BMLCs) in response to trivalent inactivated influenza vaccine (TIV) or live attenuated influenza vaccine (LAIV). We performed a randomized, …

us (code pays fourni par la source)

Assessment of Congenital Anomalies in Infants Born to Pregnant Women Enrolled in Clinical Trials

Sonja A. Rasmussen, Sonia Hernández–Dı́az, Omar Abdul‐Rahman, Leyla Şahin et autres

In 2011 and 2012, the Division of Microbiology and Infectious Diseases at the National Institute of Allergy and Infectious Diseases, National Institutes of Health, held a series of meetings to provide guidance to investigators regarding study design of clinical trials of vaccines …

us, th (code pays fourni par la source)

Safety and Immunogenicity of Tetanus, Diphtheria, and Acellular Pertussis Immunization During Pregnancy in Mothers and Infants

Flor M. Muñoz, Nanette Bond, Maurizio Maccato, Phillip Pinell et autres

Pertussis has reemerged in the United States despite high childhood immunization rates. To protect young infants, tetanus, diphtheria, and acellular pertussis vaccine (Tdap) has been used in postpartum women and close contacts of infants, in previously Tdap unimmunized pregnant women, as well …

us (code pays fourni par la source)

Safety and Immunogenicity of Tetanus Diphtheria and Acellular Pertussis (Tdap) Immunization During Pregnancy in Mothers and Infants

Flor M. Muñoz, Nanette Bond, Maurizio Maccato, Phillip Pinell et autres

IMPORTANCE: Maternal immunization with tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine could prevent infant pertussis. OBJECTIVE: To evaluate the safety and immunogenicity of Tdap immunization during pregnancy and its effect on infant responses to diphtheria and tetanus toxoids and …

us (code pays fourni par la source)

Immunogenicity of an Inactivated Monovalent 2009 H1N1 Influenza Vaccine in Pregnant Women

Lisa A. Jackson, Shital M. Patel, Geeta K. Swamy, Sharon E. Frey et autres

BACKGROUND: Although pregnant women are at increased risk of severe illness following influenza infection, there is relatively little information on the immunogenicity of influenza vaccines administered during pregnancy. METHODS: We conducted a clinical trial that enrolled 120 pregnant women in which participants …

us (code pays fourni par la source)

A single immunization with a dry powder anthrax vaccine protects rabbits against lethal aerosol challenge

Sheri D Klas, Carey R. Petrie, Sarah J. Warwood, Michael S. Williams et autres

us (code pays fourni par la source)