Kristen L. Shogren

RNA-dependent protein kinase is required for interferon-γ-induced autophagy in MG63 osteosarcoma cells

Jie Xu, Yuqing Ji, Kristen L. Shogren, Scott H. Okuno et autres

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The inhibitory effects of vancomycin on rat bone marrow–derived mesenchymal stem cell differentiation

Kari L. Hanson, Carly Isder, Kristen L. Shogren, Anthony L. Mikula et autres

OBJECTIVE: The use of intrawound vancomycin powder in spine surgery has been shown to decrease the rate of surgical site infections; however, the optimal dose is unknown. High-dose vancomycin inhibits osteoblast proliferation in vitro and may decrease the rate of solid arthrodesis. …

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Detection of macromolecular inversion–induced structural changes in osteosarcoma cells by FTIR microspectroscopy

Vitalii Serdiuk, Kristen L. Shogren, Tetiana Kovalenko, Bakhtiyor Rasulev et autres

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Autophagy markers and RNA-dependent protein kinase (PKR) activity in osteosarcoma diagnosis and treatment

Yuqing Ji, Madison N. Okuno, Kristen L. Shogren, Karen Fritchie et autres

Background: Osteosarcoma is bone malignancy that most commonly affects children and adolescents. A combination of surgery and chemotherapy has reduced the mortality rate in the past decades; however the mortality rate due to osteosarcoma metastasis continues to be very high. Autophagy is …

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STIM1 expression is associated with osteosarcoma cell survival

Jie Zang, Dongqing Zuo, Kristen L. Shogren, Carl T. Gustafson et autres

ObjectiveTo examine the role of store-operated calcium entry (SOCE) and stromal interaction molecule 1 (STIM1) in survival and migration of osteosarcoma cells and investigate what blockade of store-operated Ca2+ contributes to the regulation of osteosarcoma cells. MethodsFirst, we examined the expression levels …

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Inhibition of STAT3 blocks protein synthesis and tumor metastasis in osteosarcoma cells

Dongqing Zuo, Kristen L. Shogren, Jie Zang, Donna E. Jewison et autres

BACKGROUND: Osteosarcoma is the most common bone cancer. Despite advances, molecular mechanisms associated with osteosarcoma have not been fully understood. Hence, an effective treatment for osteosarcoma has yet to be developed. Even though signal transducer and activator of transcription3 (STAT3) has been …

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Decreased local and systemic levels of sFRP3 protein in osteosarcoma patients

Dalibel Bravo, Ahmet Salduz, Kristen L. Shogren, Madison N. Okuno et autres

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FH535 Suppresses Osteosarcoma Growth In Vitro and Inhibits Wnt Signaling through Tankyrases

Carl T. Gustafson, Tewodros Mamo, Kristen L. Shogren, Avudaiappan Maran et autres

Osteosarcoma is an aggressive primary bone tumor which exhibits aberrantly activated Wnt signaling. The canonical Wnt signaling cascade has been shown to drive cancer progression and metastasis through the activation of β-catenin. Hence, small molecule inhibitors of Wnt targets are being explored …

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Three-Dimension-Printed Porous Poly(Propylene Fumarate) Scaffolds with Delayed rhBMP-2 Release for Anterior Cruciate Ligament Graft Fixation

Joshua A. Parry, Maurits G.L. Olthof, Kristen L. Shogren, Mahrokh Dadsetan et autres

Anterior cruciate ligament (ACL) ruptures reconstructed with tendon grafts are commonly fixed with bioabsorbable implants, which are frequently complicated by incomplete bone filling upon degradation. Bone regeneration after ACL reconstruction could be enhanced by utilizing tissue engineering techniques and three-dimensional (3D) printing …

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2‐Methoxyestradiol‐Mediated Induction of Frzb Contributes to Cell Death and Autophagy in MG63 Osteosarcoma Cells

Dalibel Bravo, Kristen L. Shogren, Dongqing Zuo, Eric R. Wagner et autres

Osteosarcoma is a bone tumor that mainly affects children and adolescents. Although its pathogenesis is still not fully understood, activation of Wnt signaling has been implicated in the development and metastasis of osteosarcoma. In this report, we have investigated the effect of …

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The estrogen metabolite 2-methoxyestradiol regulates eukaryotic initiation factor 4E (eIF4E) and inhibits protein synthesis in MG63 osteosarcoma cells

Avudaiappan Maran, Kristen L. Shogren, Michael J. Yaszemski

Osteosarcoma is a primary bone tumor that affects children and young adults. The estrogen metabolite 2-methoxyestradiol (2-ME) induces cell death in osteosarcoma cells. To determine whether 2-ME actions involve the control of protein synthesis, we studied the effect of 2-ME on eukaryotic …

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Inhibition of Autophagy Increases 2-Methoxyestradiol-Induced Cytotoxicity in SW1353 Chondrosarcoma Cells

Stephan Reumann, Kristen L. Shogren, Michael J. Yaszemski, Avudaiappan Maran

Chondrosarcoma is a cartilage tumor and is the second most common malignant bone cancer. Unlike many tumors, chondrosarcomas are resistant to conventional chemotherapy and radiotherapy. Autophagy is a homeostatic mechanism through which cellular proteins and organelles are subjected to lysosomal degradation and …

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