Daniel Aeschbach

Judicious elevation of ambient carbon dioxide during hypobaric hypoxia to improve oxygenation in airline passengers: a randomized feasibility study

Titiaan E. Post, Riccardo De Gioannis, Daniel Rooney, M. Wittkowski et autres

Elevating ambient CO 2 can improve blood and brain oxygenation in healthy individuals during moderate hypoxia as experienced in an airliner cabin. The findings offer a new approach potentially benefiting the health and safety of airline passengers and support investigating CO 2 …

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The efficacy of pink noise and earplugs for mitigating sleep disruption induced by different environmental noise sources

Mathias Basner, Michael G Smith, Makayla Cordoza, Matthew S Kayser et autres

OBJECTIVES: To investigate the efficacy of pink noise and earplugs in mitigating sleep fragmentation induced by intermittent environmental noise. METHODS: Twenty-five healthy adults (mean ± SD age 28.5 ± 5.9 years, 7 male) participated in a polysomnographic laboratory study with intermittent exposure …

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Chronic sleep loss and A1 adenosine receptors in the human brain

Denise Lange, Eva Hennecke, Katharina Thiel, Bernd Neumaier et autres

STUDY OBJECTIVES: The cerebral adenosinergic system is involved in sleep-wake regulation and presumably represents a neuro-molecular correlate of homeostatic sleep pressure. For acute sleep deprivation, it has been shown that increased cerebral A1 adenosine receptor (A1AR) availability was related to impairments in …

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Efficacy of pink noise and earplugs for mitigating the effects of intermittent environmental noise exposure on sleep

Mathias Basner, M. Smith, Makayla L. Cordoza, Matthew S. Kayser et autres

STUDY OBJECTIVES: Nighttime environmental noise (EN) exposure disturbs sleep and increases morbidity and mortality. Affordable and effective countermeasures are needed, but rigorous research is scarce. This study investigates the efficacy of pink noise (PN) and earplugs for mitigating the effects of intermittent …

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Assessment of the acceptability of sonic booms of planned supersonic commercial aircraft or business jets

Daniel Aeschbach, Susanne Bartels, Sarah Weidenfeld, Julia Kuhlmann et autres

Future civil supersonic aircraft (low-boom aircraft) are intended to produce significantly quieter sonic booms. The effects of these novel sonic booms on humans, especially on sleep, are still unclear. In one study, 37 people were examined in a sleep laboratory. The results …

Beurteilung der Zumutbarkeit von Überschallknallen geplanter Überschall-Verkehrsflugzeuge bzw. -Geschäftsreiseflugzeuge

Daniel Aeschbach, Susanne Bartels, Sarah Weidenfeld, Julia Kuhlmann et autres

Zukünftige zivile Überschallflugzeuge (Low-Boom-Flugzeuge) sollen deutlich leisere Überschallknalle verursachen. Die Wirkung dieser neuartigen Überschallknalle auf den Menschen, insbesondere auf den Schlaf, ist bisher unklar. In einer Studie wurden 37 Personen im Schlaflabor untersucht. Die Ergebnisse zeigen, dass der Schlaf in der Low-Boom-Bedingung …

Sauerstoffmangel im Gehirn: Perfusion und Verfügbarkeit von A1-Adenosinrezeptoren

Henning Weis, Eva-Maria Elmenhorst, David Elmenhorst, Manuel Michno et autres

Zusammenfassung In Nagern wurde beobachtet, dass der Neuromodulator Adenosin während Hypoxie im Gehirn freigesetzt wird und es vor Sauerstoffmangel und Überlastung schützt, indem Blutfluss, Stoffwechsel und elektrische Aktivität angepasst werden. An 10 Probanden wurde geprüft, ob durch Hypoxie – einem Sauerstoffpartialdruck auf …

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Simulierte Schwerelosigkeit beeinträchtigt Schlafdauer und -qualität

Luise Strauch, Melanie von der Wiesche, Alexandra Noppe, Edwin R. Mulder et autres

Zusammenfassung Während des Aufenthalts in Schwerelosigkeit ist häufig der Schlaf der Astronaut*innen beeinträchtigt. Eine kontinuierliche Körperposition in 6°-Kopftieflage (HDT) simuliert viele physiologische Veränderungen, die in Schwerelosigkeit auftreten. 24 Proband*innen verbrachten 60 Tage in HDT. Die Polysomnografie wurde in der Baselinephase (BDC-9), in …

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0232 Effects of Caffeinated Coffee on Mood and Sleepiness Under Sleep Restriction Conditions

Eva‐Maria Elmenhorst, Eva Hennecke, Denise Lange, Diego M. Baur et autres

Abstract Introduction It has been shown that mood is disturbed by sleep restriction (SR). We examined how mood and sleepiness after SR are impacted by the use of caffeinated coffee. Methods Data from 72 volunteers were assessed during 3 baseline and 5 …

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Cooperative teamwork in a simulated control room as a countermeasure against performance impairment due to the combined effects of sleep loss and circadian misalignment

Sibylle Benderoth, Christian Mühl, Carmen Bruder, Dirk Schulze Kissing et autres

STUDY OBJECTIVES: Although teamwork under fatigue is highly common in the workplace, the effects of sleep loss on group performance have rarely been studied. Here, we examined whether cooperative teamwork in a control room setting has a protective effect by attenuating performance …

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Resetting of the Human Circadian Melatonin Rhythm by Ambient Hypoxia

Titiaan E. Post, Riccardo De Gioannis, Jan Schmitz, M. Wittkowski et autres

ABSTRACT Circadian clocks in the body drive daily cycles in physiology and behavior. A master clock in the brain maintains synchrony with the environmental day–night cycle and uses internal signals to keep clocks in other tissues aligned. Work in cell cultures uncovered …

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Oxygen deficiency in the brain: perfusion and availability of A 1 adenosine receptors

Manuel Michno, Jan Schmitz, Eva-Maria Elmenhorst, David Elmenhorst et autres