Emilie Dugast

Blood cytotoxic natural killer-like CD8 + CD94+ T cells migrate to the brain and predict multiple sclerosis severity

Emilie Dugast, Sita Shah, Isabel Vogel, Amandine Loret et autres

Memory CD8+ T cells are central to multiple sclerosis (MS) and undergo clonal expansion, but disease-associated states remain incompletely defined. By single-cell profiling of circulating memory CD8+ T cells from patients with relapsing-remitting MS, healthy volunteers, and neuroinflammatory controls, we identified an …

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Unhealthy food bias in food addiction: behavioral evidence from a probabilistic image choice task

Marcello Solinas, Sabrina Ingrand, Claudia Chauvet, Emilie Dugast et autres

Food addiction (FA) shares behavioral and neurobiological similarities with substance use disorders, but objective behavioral measures of FA are lacking. We aimed to adapt the Probabilistic Image Choice (PIC) task to assess behavioral bias toward unhealthy food, and to determine its association …

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Unhealthy Food Bias in Food Addiction: Behavioral Evidence from a Probabilistic Image Choice Task

Marcello Solinas, Sabrina Ingrand, Claudia Chauvet, Emilie Dugast et autres

fr (code pays fourni par la source)

Environmental enrichment selectively counteracts brain metabolic activity during cocaine abstinence

Marcello Solinas, Pauline Belujon, Virginie Lardeux, Emilie Dugast et autres

fr, ca (code pays fourni par la source)

Durable B‐Cell Impairment While Sparing IgA B Cells After Ocrelizumab Therapy in Multiple Sclerosis

Alexandra Garcia, Stéphane Rodriguez, Emilie Dugast, Christine Lebrun‐Frénay et autres

OBJECTIVES: Ocrelizumab (OCR), a humanized anti-CD20 monoclonal antibody, is highly efficient in relapsing-remitting multiple sclerosis (RR-MS). We assessed early cellular B-cell profiles in patients prior to OCR treatment, on OCR treatment, and after 15 months of therapy discontinuation. This study aims to …

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Environmental enrichment selectively restores brain metabolic activity during cocaine abstinence

Pauline Belujon, Virginie Lardeux, Emilie Dugast, Sophie Sérrière et autres

ABSTRACT Background Environmental enrichment (EE) is a promising strategy to promote recovery from addiction, but its neurobiological mechanisms remain poorly understood. This study investigates how exposure to EE during abstinence dynamically affects brain neuroadaptations induced by voluntary intake of cocaine. Methods Using …

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Sex-dependent effects of stress on aIC-NAc circuit neuroplasticity: Role of the endocannabinoid system

Manon Gauthier, Emilie Dugast, Virginie Lardeux, Kevin Letort et autres

Stress is a major risk factor for psychiatric disorders and affects neuroplasticity in brain areas like the nucleus accumbens core (NAcC) and the insular cortex (IC). This study examined neuroplasticity changes in the aIC-NAcC circuit after restraint stress in male and female …

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Optimization of permeabilized brain tissue preparation to improve the analysis of mitochondrial oxidative capacities in specific subregions of the rat brain

Léa Dorémus, Emilie Dugast, Arnaud Delafenêtre, Morgane Delouche et autres

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Cholinergic-Dependent Metaplasticity in the Amygdala–Insula Pathway During Incubation of Cocaine Craving

Adélie Salin, Virginie Lardeux, Emilie Dugast, Éric Balado et autres

Cognitive effort increases the intensity of rewards

Mejda Wahab, Nicole L. Mead, Stevenson Desmercieres, Virginie Lardeux et autres

An important body of literature suggests that exerting intense cognitive effort causes mental fatigue and can lead to unhealthy behaviors such as indulging in high-calorie food and taking drugs. Whereas this effect has been mostly explained in terms of weakening cognitive control, …

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Cholesterol 24-hydroxylase overexpression in the dorsal striatum reduces relapse to cocaine-seeking

Nathalie Thiriet, S. Desmercières, Thomas Aupy, Youna Vandaele et autres

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Stress selectively modulates neuronal plasticity in the insular cortex-nucleus accumbens pathway.

Manon Gauthier, Emilie Dugast, Virignie Lardeux, Kevin Letort et autres

Background and Purpose Stress is a major risk factor for psychiatric disorders and significantly affects neuroplasticity in brain areas including the nucleus accumbens (NAc) and the insular cortex (IC). Here, we examined alterations in neuroplasticity within the aIC-NAc circuit following restraint stress …

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