Dylanis Lopez Ruiz

Review on smoking and its association with ocular dryness disorder

Diego Francisco Pérez Villarroel, Dylanis Lopez Ruiz, Natalia Estefanía Chacón-Manjarrez

Background: The tear film acts as the primary protective barrier of the eye, ensuring its proper hydration and nutrition. This thin layer, composed of water, lipids, and proteins, can be compromised by various factors, among which is smoking. This is a frequently …

ec (code pays fourni par la source)

Age-specific penetrance ofLRRK2G2019S in the Michael J. Fox Ashkenazi Jewish LRRK2 Consortium

Karen Marder, Yuanjia Wang, Roy N. Alcalay, Helen Mejia‐Santana et autres

OBJECTIVE: Estimates of the penetrance of LRRK2 G2019S vary widely (24%-100%), reflective of differences in ascertainment, age, sex, ethnic group, and genetic and environmental modifiers. METHODS: The kin-cohort method was used to predict penetrance in 2,270 relatives of 474 Ashkenazi Jewish (AJ) …

il, us (code pays fourni par la source)

The relationship between obsessive‐compulsive symptoms and PARKIN genotype: The CORE‐PD study

Madeleine Sharp, Elise Caccappolo, Helen Mejia‐Santana, Ming‐X. Tang et autres

BACKGROUND: Few studies have systematically investigated the association between PARKIN genotype and psychiatric co-morbidities of Parkison's disease (PD). PARKIN-associated PD is characterized by severe nigral dopaminergic neuronal loss, a finding that may have implications for behaviors rooted in dopaminergic circuits such as …

us, pr (code pays fourni par la source)

Cognitive and Motor Function in Long-DurationPARKIN-Associated Parkinson Disease

Roy N. Alcalay, Elise Caccappolo, Helen Mejia‐Santana, Ming Tang et autres

IMPORTANCE: Data on the long-term cognitive outcomes of patients with PARKIN-associated Parkinson disease (PD) are unknown but may be useful when counseling these patients. OBJECTIVE: Among patients with early-onset PD of long duration, we assessed cognitive and motor performances, comparing homozygotes and …

us, pr (code pays fourni par la source)

Parkinson disease phenotype in Ashkenazi jews with and without LRRK2 G2019S mutations

Roy N. Alcalay, Anat Mirelman, Rachel Saunders‐Pullman, Ming‐X Tang et autres

The phenotype of Parkinson's disease (PD) in patients with and without leucine-rich repeat kinase 2 (LRRK2) G2019S mutations reportedly is similar; however, large, uniformly evaluated series are lacking. The objective of this study was to characterize the clinical phenotype of Ashkenazi Jewish …

us, il (code pays fourni par la source)

Self-medication among Workers of the Faculty of Medical Sciences of Cienfuegos

Maira Quirós Enríquez, Dylanis Lopez Ruiz, Olga Cuevas Pérez, Pedro Milián Vázquez et autres

cu (code pays fourni par la source)

The Effect of Parkin Mutation Status on Cognitive Functioning in EOPD Patients with Long Disease Duration: The CORE-PD Study (PD7.008)

Elise Caccappolo, Roy N. Alcalay, Karen Marder, M.‐X. Tang et autres

Objective: To compare the cognitive performance carriers and non-carriers of parkin mutations with long disease duration. Background We and others have reported that early-onset Parkinson disease (EOPD) individuals who are parkin mutation carriers have similar neuropsychological performance to non-carriers; however, it is …

us (code pays fourni par la source)

Estimating the Cumulative Risk of PD in Carriers of Parkin Mutations: The CORE-PD Study (PD4.007)

Karen Marder, Ming Tang, Roy N. Alcalay, L. Rosado et autres

Cognitive performance of GBA mutation carriers with early-onset PD

Roy N. Alcalay, Elise Caccappolo, Helen Mejia‐Santana, Ming Tang et autres

OBJECTIVE: To assess the cognitive phenotype of glucocerebrosidase (GBA) mutation carriers with early-onset Parkinson disease (PD). METHODS: We administered a neuropsychological battery and the University of Pennsylvania Smell Identification Test (UPSIT) to participants in the CORE-PD study who were tested for mutations …

no, us (code pays fourni par la source)

Olfaction in Parkin heterozygotes and compound heterozygotes

Roy N. Alcalay, Andrew Siderowf, Ruth Ottman, Elise Caccappolo et autres

BACKGROUND: While Parkinson disease (PD) is consistently associated with impaired olfaction, one study reported better olfaction among Parkin mutation carriers than noncarriers. Whether olfaction differs between Parkin mutation heterozygotes and carriers of 2 Parkin mutations (compound heterozygotes) is unknown. OBJECTIVE: To assess …

us, nl (code pays fourni par la source)