Chia‐Ling Tu

Amyloid-β as a target to suppress tonic PTH hypersecretion in hyperparathyroidism due to vitamin D deficiency

Chia‐Ling Tu, Zhiqiang Cheng, Nicholas Szeto, Sofya Savransky et autres

Hyperparathyroidism is an endocrine disorder linked to vitamin D deficiency. Reduced vitamin D receptor (VDR) activity promotes parathyroid hormone (PTH) hypersecretion by increasing heterodimerization of the type B γ-aminobutyric acid receptor 1 (GABA B1 R) with the extracellular Ca 2+ -sensing receptor …

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Selective tau vulnerability in the human master circadian clock in atypical Alzheimer's disease

Gowoon Son, Mihovil Mladinov, Felipe Luiz Pereira, Yumi Yang et autres

BACKGROUND: Recently recognized syndromic variants in cases with AD pathology reflect regional differences in susceptibility to AD-tau pathology. We found systematic differences in sleep architectures between amnestic (amAD) and atypical AD (atypAD), including evidence of a more blunted circadian rhythm pattern in …

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Transcriptional and neuroprotective effects of hexokinase-2 inhibitors administered after stroke

Seok Joon Won, Gӧkhan Uruk, Nguyen Mai, Chia‐Ling Tu et autres

BACKGROUND: The delayed inflammatory response induced by stroke can cause secondary injury to peri-infarct tissue. Microglia and other immune cells that mediate this injury require increased glycolytic flux for pro-inflammatory activation. These cells, unlike neurons, astrocytes, and most other cell types, utilize …

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β-Amyloid as a new target to suppress tonic PTH hypersecretion in primary hyperparathyroidism

Chia‐Ling Tu, Zhiqiang Cheng, Nicholas Szeto, Sofya Savransky et autres

Abstract Primary hyperparathyroidism (PHPT) is a common endocrine disorder of aging closely linked to vitamin D deficiency. Reduced vitamin D receptor activities promote parathyroid hormone (PTH) hypersecretion by increasing the heterodimerization of the type B γ-aminobutyric acid receptor 1 (GABA B1 R) …

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Extracellular Ca 2+ -Sensing Receptor (CaSR) Regulates Hypothalamic Function to Control Energy and Skeletal Metabolism in Mice

Jennifer Park-Sigal, Mariana Norton, Chia‐Ling Tu, Zhiqing Cheng et autres

Introductory paragraph The extracellular Calcium-sensing receptor (CaSR) regulates cellular responsiveness to physiological changes in ionized calcium (Ca 2+ ) concentrations. The CaSR is expressed in the brain, including in hypothalamic growth hormone stimulating GHRH and anorectic POMC neurons that control growth and …

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Transcriptional and neuroprotective effects of hexokinase-2 inhibitors administered after stroke

Seok Joon Won, Gӧkhan Uruk, Nguyen Mai, Chia‐Ling Tu et autres

ABSTRACT The inflammatory response induced by stroke can exacerbate injury to peri-infarct tissue. Microglia and other immune cells that mediate this response require increased glycolytic flux during pro-inflammatory activation. These cells, unlike neurons and most other cell types, utilize hexokinase-2 (HK2) rather …

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The human master circadian clock is vulnerable to tau pathology in the early stages of Alzheimer’s: a postmortem neuropathology using spatial in‐situ proteomics

Gowoon Son, Mihovil Mladinov, Felipe Luiz Pereira, Song Hua Li et autres

BACKGROUND: Alzheimer's Disease(AD) patients experience circadian rhythm disorder. The circadian rhythm is synchronized by a master clock, the suprachiasmatic nucleus(SCN), which is spatially well-conserved but a tiny nucleus in the hypothalamus. Little is known about the molecular and pathological changes that occur …

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Neuronal Calcium‐Sensing Receptor Is A Druggable Target To Treat Alzheimer’s Disease

Chia‐Ling Tu, Kota Kurisu, Zhiqiang Cheng, Stephanie R. Miller et autres

Abstract Background Effective disease‐modifying regimens for Alzheimer’s Disease (AD) remain lacking due to insufficient understanding of its pathogenic drivers. It was shown previously that upregulation of the calcium‐sensing receptor (CaSR), an excitatory family C GPCR, induces neurodegeneration by interfering with the inhibitory …

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Targeted Deletion of Fibroblast Growth Factor 23 Rescues Metabolic Dysregulation of Diet-induced Obesity in Female Mice

Min Young Park, Chia‐Ling Tu, Luce Pèrié, Narendra Verma et autres

Fibroblast growth factor 23 (FGF23) is a bone-secreted protein widely recognized as a critical regulator of skeletal and mineral metabolism. However, little is known about the nonskeletal production of FGF23 and its role in tissues other than bone. Growing evidence indicates that …

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The Paradise of Extreme Joy: Where We Are Temporarily Liberated; Although This is Not the Ultimate Realm for Souls

Christopher Hartney, Công Tâm Đào, Chia‐Ling Tu

The Textual-Historical Divisions of Tây Ninh Caodaism

Christopher Hartney, Chia‐Ling Tu

7052 Beta-Amyloid Mediates PTH Hypersecretion In Hyperparathyroidism Associated With Vitamin D Deficiency

Chia‐Ling Tu, Zhiqiang Cheng, Karina A. Peña, Sofya Savransky et autres

Abstract Disclosure: C. Tu: None. Z. Cheng: None. K.A. Pena: None. S. Savransky: None. T. Glinin: None. N. Szeto: None. J.A. Sosa: Research Investigator; Self; Institutional research funding and Data Monitoring Committee of the Medullary Thyroid Cancer Consortium Registry, supported by, AstraZeneca, …

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