Salma M. Khirallah

Vanillic acid, agmatine, and silver nanoparticles enhanced Nrf2 pathway and inhibited inflammatory, apoptotic, and fibrotic signaling in cadmium-induced nephrotoxicity in rats

Nashwa Barakat, Sara Helaly, Salma M. Khirallah

Égypte (code pays fourni par la source)

Synergistic protective effects of melatonin and selenium nanoparticles against cisplatin-induced nephrotoxicity through modulation of the Nrf2/HO-1 and Bax/Bcl-2 pathways

Faten M. Zahran, Nashwa Barakat, ehab saber Ismail, Salma M. Khirallah

AIM: The objective of this study was to assess the protective effects of melatonin (Mel) and selenium nanoparticles (SeNPs) against cisplatin (Cis)-induced nephrotoxicity in rats. METHODS: Sixty male rats were categorised into five groups: Control, Cis, Cis + Mel, Cis + SeNPs, …

Égypte (code pays fourni par la source)

Dual-action 1 H-1,2,3-triazole-zinc oxide nanohybrids: a promising strategy against microbes and cancer

Salma M. Khirallah, Salma S. M. S. Metawea, Ibrahim A. Mohi El-Din, Mohamed M. El-Zahed et autres

Abstract The rise of drug-resistant infections and cancer highlights the urgent need for new therapeutic agents. This study aimed to synthesize a novel triazole-based compound and its ZnO nanocomposite to evaluate their antimicrobial and anticancer potential. N-(4-nitrophenyl)-1-(4-(N-(pyridin-2-yl)sulfamoyl)phenyl)-1H-1,2,3-triazole-4-carboxamide (NPST) was prepared and combined …

Égypte (code pays fourni par la source)

Erythropoietin and Ferulic Acid Loaded on Fe3O4 Nanoparticles Exert Therapeutic Effect against Acute Kidney Injury Induced by Cisplatin Via Bcl-2/Bax, IL-6, TGF-β, and GPX-4 Mechanisms

Lamiaa A. A. Barakat, Aya Ashour Aref, Salma M. Khirallah

Background: Acute kidney damage occurs in 30%–46% of patients receiving cisplatin chemotherapy; nevertheless, effective preventive and treatment strategies are insufficient. Ferulic acid, despite its potent antioxidant and anti-inflammatory properties, exhibits from poor aqueous solubility, rapid metabolism, and low bioavailability, which significantly limit …

Égypte (code pays fourni par la source)

Optimized CoQ10 delivery via ZnO/CuO nanoparticles: greater in vitro cell cycle arrest and in vivo tumor suppression than unformulated coenzyme Q10

Lamiaa A. A. Barakat, Radwa K.A. Hassan, Salma M. Khirallah, Mohammed El Behery et autres

arrest at 73.7% while also causing both early and late apoptosis together with Bax and Caspase-3 upregulation and Bcl-2 downregulation, and topoisomerase IIβ and NRF-2 and TNF-α and β-catenin pathways. The two formulations achieved hepatorenal biomarker normalization together with antioxidant enzyme activity …

Égypte (code pays fourni par la source)

Cytokeratin 18 and soluble cluster of differentiation-36: markers for nephropathy in patients with metabolic dysfunction-associated fatty liver disease

Hassan Shora, Ibrahim M. El‐Deen, Naglaa M. El-Lithy, Dina Mohamed Abo–Elmatty et autres

Abstract Background Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) is considered the hepatic aspect of metabolic disorders and is associated with an increased risk of chronic kidney disease (CKD). Aim This study aimed to assess the potential association of Cytokeratin-18 (CK-18) and soluble …

au, Égypte (code pays fourni par la source)

Potential role of pentraxin 3 (PTX3) and aldehyde dehydrogenase (ALDH) in liver cirrhotic patients: predicting and diagnostic impact in hepatocellular carcinoma (HCC) development

Hoda Mohamed El-Emshaty, Elsaid Ali Eladle, Mohamed Abdelwahab, Salma M. Khirallah

Égypte (code pays fourni par la source)

Daxas provides renoprotective effects in ischemia-reperfusion injury by targeting apoptosis, oxidative stress, and inflammation pathways

Nashwa M. Barakat, Karam Ahmed El-Sharkawy, Aml Awad, Salma M. Khirallah

Égypte (code pays fourni par la source)

Growth differentiation factor-15: A marker for diabetic kidney disease in patients with metabolic-associated fatty liver disease

Hassan Shora, Ibrahim M. El‐Deen, Naglaa M. El-Lithy, Dina Mohamed Abo–Elmatty et autres

au, Égypte (code pays fourni par la source)

Effect of Melatonin and Ginseng on rat testis and sperm quality against cadmium toxicity via inhibiting oxidative stress and autophagy pathways

Nashwa M. Barakat, Mona A Alkhen, Yomna T. T. Khater, Salma M. Khirallah

Égypte (code pays fourni par la source)

Electrospun nanostructured heparin conjugated-poly-ε-caprolactone based scaffold promote differentiation of smooth muscle cells from adipose mesenchymal stem cells

Amira Awadalla, Tarek A. Elkhooly, Ahmed El‐Assmy, Eman T. Hamam et autres

Égypte (code pays fourni par la source)

Human Wharton's jelly-derived mesenchymal stromal stem cells preconditioned with valproic acid promote cell migration and reduce renal inflammation in ischemia/reperfusion injury by activating the AKT/P13K and SDF1/CXCR4 pathways

Ahmed A. Shokeir, Amira Awadalla, Eman T. Hamam, Abdelaziz M. Hussein et autres

Égypte, sa (code pays fourni par la source)