Alberto Luridiana

Cyclopropylamine‐Derived Distonic Iminium Radicals: Photoinduced Strategies in Chemo‐ and Stereo‐Selective Synthesis

Maria Chiara Cabua, Alberto Luridiana, Francesco Secci, Emanuele Cocco

Cyclopropylamines have emerged as privileged substrates in photocatalysis owing to their propensity to undergo single‑electron oxidation followed by strain‑release β-scission, generating highly reactive distonic iminium radicals. These intermediates underpin a broad repertoire of light-driven transformations, including ring‑opening functionalization, formal [3 + 2] …

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Light‐Driven [2 + 2] Cycloaddition Strategies for the Synthesis of Cyclobuta[ b ]indoles and Their Derivatives

Maria Chiara Cabua, Davide Moi, Alberto Luridiana, Francesco Secci et autres

The dearomatization of indoles is a powerful strategy for transforming simple substrates into architecturally complex molecular frameworks. This review provides a comprehensive overview of photoinduced methodologies developed for the construction of three‐dimensional polycyclic systems bearing indolyl‐cyclobutane motifs. We summarize classical ultraviolet(‐driven [2 …

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A straightforward route to substituted 1-pyrrolines via photocatalyzed ring-opening cyclization of cyclopropyl enamines

Alberto Luridiana, Francesco Soddu, Davide Pusceddu, Luca Virdis et autres

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Two-step continuous flow-driven synthesis of 1,1-cyclopropane aminoketones

Viktoria Velichko, Davide Moi, Francesco Soddu, Roberto Scipione et autres

tandem condensation C4-C3-ring contraction reaction. With the achieved operational conditions, we were able to obtain a library of cyclopropylamines with good chemical yields, high productivity, and short residence times.

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Giese-type alkylation of dehydroalanine derivatives via silane-mediated alkyl bromide activation

Perry van der Heide, Michele Retini, Fabiola Fanini, Giovanni Piersanti et autres

The rising popularity of bioconjugate therapeutics has led to growing interest in late-stage functionalization (LSF) of peptide scaffolds. α,β-Unsaturated amino acids like dehydroalanine (Dha) derivatives have emerged as particularly useful structures, as the electron-deficient olefin moiety can engage in late-stage functionalization reactions, …

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C1‐4 Alkylation of Aryl Bromides with Light Alkanes enabled by Metallaphotocatalysis in Flow

Antonio Pulcinella, Prakash Chandra Tiwari, Alberto Luridiana, Ken Yamazaki et autres

Abstract The homologous series of gaseous C1‐4 alkanes represents one of the most abundant sources of short alkyl fragments. However, their application in synthetic organic chemistry is exceedingly rare due to the challenging C−H bond cleavage, which typically demands high temperatures and …

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C1‐4 Alkylation of Aryl Bromides with Light Alkanes enabled by Metallaphotocatalysis in Flow

Antonio Pulcinella, Prakash Chandra Tiwari, Alberto Luridiana, Ken Yamazaki et autres

Abstract The homologous series of gaseous C1‐4 alkanes represents one of the most abundant sources of short alkyl fragments. However, their application in synthetic organic chemistry is exceedingly rare due to the challenging C−H bond cleavage, which typically demands high temperatures and …

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C1-4 Alkylation of Aryl Bromides with Light Alkanes enabled by Metallaphotocatalysis in Flow

Antonio Pulcinella, Prakash Tiwari, Alberto Luridiana, Ken Yamazaki et autres

The homologous series of gaseous C1-4 alkanes represents one of the most abundant sources of short alkyl fragments. However, their application in synthetic organic chemistry is exceedingly rare due to the challenging C–H bond cleavage, which typically demands high temperatures and pressures, …

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Flow photochemical Giese reaction via silane-mediated activation of alkyl bromides

Fabiola Fanini, Alberto Luridiana, Daniele Mazzarella, Antonella Ilenia Alfano et autres

Organic halides play a key role as building blocks in synthesis because of their low cost and wide availability. In recent years, halogen-atom transfer (XAT) has emerged as a reliable approach to exploit these substrates in radical processes. Herein, we report a …

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The Merger of Benzophenone HAT Photocatalysis and Silyl Radical-Induced XAT Enables Both Nickel-Catalyzed Cross-Electrophile Coupling and 1,2-Dicarbofunctionalization of Olefins

Alberto Luridiana, Daniele Mazzarella, Luca Capaldo, Juan A. Rincón et autres

) bonds. The mild protocol is fast and scalable using flow technology, displays broad functional group tolerance, and is amenable to a wide variety of medicinally relevant moieties. Mechanistic investigations reveal that the ketone catalyst, upon photoexcitation, is responsible for the direct …

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Z‐Selective Synthesis of α‐Sulfanyl Carbonyl Compounds from Internal Alkynes and Thiols via Photoredox Catalysis

Alberto Luridiana, Angelo Frongia, Mariano Andrea Scorciapino, Giuliano Malloci et autres

Abstract A synthetically useful Z‐selective cascade formal thiyl radical addition, 1,3‐double bond isomerization, oxygen trapping reaction, can be promoted by Eosin B under visible light, leading to the construction of 2‐aryl‐ and alkylthio enone derivatives in good yields. An accurate study on …

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Synthesis and characterization of a new triazine-based NUV-blue excitable material for phosphor-converted LED technologies

Alberto Luridiana, Luigi Stagi, Guido Ennas, Carlo Maria Carbonaro et autres

A thermally stable fluorescent triazine-based material (TABNO) showing bright solid state photoluminescence has been synthetized. Blending TABNO with K 2 SiF 6 :Mn 4+ allowed access to a new class of REE free blue excitable warm light-emitting phosphors.

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