Heather Wilson‐Robles

Pilot study evaluating tolerability and changes in fecal microbiota associated with novel probiotic administration to dogs with diarrhea

Jessi Doshier, Brooke Anderson, Fan Yang, Samuel D. Stewart et autres

Background Diarrhea is one of the most common reasons for visiting canine veterinary clinics or emergency centers. Common treatment approaches include dietary modification, antibiotics, and/or probiotics, which are frequently initiated empirically. Antibiotics can have detrimental long-term effects on the gut microbiome and …

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Low prevalence of hemoperitoneum recurrence in dogs following splenectomy for benign splenic tumors

Brooke T. Fourthman, Samuel D. Stewart, Heather Wilson‐Robles, Chand Khanna et autres

Introduction: The purpose of this study is to describe the outcomes and prevalence of hemoperitoneum recurrence in dogs presumptively cured following splenectomy for spontaneously ruptured benign splenic lesions. Methods: A retrospective analysis of a cohort of 83 client-owned dogs with spontaneous hemoperitoneum …

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Intravenous allogeneic mesenchymal stromal cell therapy in 13 Pugs with presumptive early necrotizing meningoencephalitis

Rebecca Windsor, Samuel D. Stewart, Jennifer M. Cassano, Boaz Arzi et autres

Objective: To describe the tolerability and activity of IV allogeneic mesenchymal stromal cell (MSC) therapy in 13 Pugs with presumptive early necrotizing meningoencephalitis (NME). Methods: 255 Pugs were screened from 2021 to 2024 for neurological examination (NE) abnormalities suggestive of early NME. …

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Evaluation of plasma nucleosome concentrations and the effect of pre-analytical variables in healthy cats

Emily Westerback, Heather Wilson‐Robles, Mhammed Bougoussa, Stephanie Istvan et autres

BACKGROUND: Nucleosome levels have been shown to increase in dogs and humans in certain disease states, as a result of cell apoptosis, raising interest in their utility as a biomarker. Detection of nucleosomes in feline blood has yet to be described. Optimal …

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A prospective observational study of 345 canines with ruptured splenic tumors suggests benign lesions are more common than previously reported

Elise Ruffoni, Samuel D. Stewart, Chand Khanna, Chris Thomson et autres

Objective: To define the histopathologic diagnoses and clinical stage from a prospectively enrolled cohort of dogs with spontaneous hemoperitoneum (SH) of splenic origin undergoing splenectomy. Methods: This post hoc analysis of prospective data evaluated canine patients presenting with SH enrolled into a …

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Immunological responses and clinical outcomes in dogs with osteosarcoma receiving standard therapy and a Listeria vaccine expressing HER2

Nicola J. Mason, Laura E. Selmic, Audrey Ruple, Cheryl A. London et autres

A clinical trial in dogs with spontaneous osteosarcoma was performed to assess a recombinant Listeria expressing a chimeric human HER2 (ADXS31-164 c ) as an adjunctive vaccine strategy to prevent metastatic disease and determine immunological correlates of clinical outcome. A total of …

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Tranexamic acid versus placebo to prevent bleeding in patients with haematological malignancies and severe thrombocytopenia (TREATT): a randomised, double-blind, parallel, phase 3 superiority trial

Lise J Estcourt, Zoe McQuilten, Peter Bardy, Merrole Cole‐Sinclair et autres

34 Patients experience in the catheterization laboratory (PATCATH) undergoing coronary procedures at a single high-volume centre

H Rai, Heather Wilson‐Robles, Kayla Byrne, Seán Fitzgerald et autres

Introduction Patient-reported experience metric (PREM) questionnaires are important tools used to evaluate patient experience but have yet to be widely used for patients undergoing cardiovascular procedures. Validated PREM tools may assist healthcare providers to identify areas of quality improvement. Methods A novel …

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Noninvasive Blood-Based Cancer Detection in Veterinary Medicine

Andi Flory, Heather Wilson‐Robles

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Climate change and coastal wetland salinization: Physiological and ecological consequences for Arctic waterfowl

Tuula E. Hollmén, Paul L. Flint, Sadie E.G. Ulman, Heather Wilson‐Robles et autres

Abstract Coastal wetland salinization related to warming climate has the potential to impact ecological systems globally. In Alaska, the Yukon‐Kuskokwim Delta (YKD) supports large concentrations of breeding water birds and is an ecologically important area for conservation of migratory bird biodiversity. On …

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Monitoring plasma nucleosome concentrations to measure disease response and progression in dogs with hematopoietic malignancies

Heather Wilson‐Robles, Emma Warry, Tasha Miller, Jill Jarvis et autres

BACKGROUND: Hematopoietic malignancies are extremely common in pet dogs and represent nearly 30% of the malignancies diagnosed in this population each year. Clinicians commonly use existing tools such as physical exam findings, radiographs, ultrasound and baseline blood work to monitor these patients …

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Data from Aryl Hydrocarbon Receptor Agonists Induce MicroRNA-335 Expression and Inhibit Lung Metastasis of Estrogen Receptor Negative Breast Cancer Cells

Shu Zhang, Kyounghyun Kim, Un Ho Jin, Catherine Pfent et autres

Abstract The aryl hydrocarbon receptor (AHR) was initially identified as a receptor that bound 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related environmental toxicants; however, there is increasing evidence that the AHR is an important new drug target for treating multiple diseases including breast cancer. Treatment …