Daniel B. Zoccal

Pain relief but respiratory depression: Insights into the dark side of opioid overuse

Daniel B. Zoccal

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Luteolin increases baseline apneas and downregulates brainstem HIF in normoxia and chronic intermittent hypoxia

Bolival Apparecido [UNIFESP] Mendonça Junior, André Acácio Souza da Silva, Estela Sasso-Cerri, Angelita Maria Stabile et autres

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Neural Control of Tissue Perfusion: Emerging Evidence and Beyond

Eduardo Colombari, Gustavo Rodrigues Pedrino, Pedro L. Katayama, Daniel B. Zoccal et autres

PURPOSE OF REVIEW: Tissue perfusion is tightly regulated by central neural circuits that integrate autonomic and sensory inputs to match blood flow to tissue metabolic demand. This review synthesizes current knowledge on the central mechanisms governing tissue perfusion in both physiological and …

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Carotid body sensing of systemic inflammation contributes to recruitment of the splanchnic anti-inflammatory pathway

Tales F. V. Rosin, Livia E.C. Corrêa, Rodrigo S. Morais, Isabela P. Leirão et autres

• Systemic LPS increases splanchnic sympathetic nerve activity. • Carotid body ablation attenuates LPS-induced splanchnic sympathetic activation. • Disruption of carotid body input or splanchnic sympathetic outflow exacerbates LPS-induced inflammatory responses. • LPS drives RVLM neuronal activation in a carotid body–dependent manner. …

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Sympathetic innervation of the temporomandibular joint modulates local hyperalgesia and IL-6 levels in zymosan-induced inflammatory pain

Tales F. V. Rosin, Fernanda Medeiros, Isabela P. Leirão, Eduardo Colombari et autres

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Respiratory and Metabolic Effects of Active Expiration in Freely Behaving Rats

Isabela P. Leirão, Pedro L. Katayama, Daniel B. Zoccal

AIM: Exposure to low oxygen (hypoxia) or high carbon dioxide levels (hypercapnia) leads to a compensatory increase in pulmonary ventilation. Among the motor changes supporting the respiratory responses is the recruitment of abdominal expiratory muscles (ABD), which can enhance expiratory airflow or …

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Effecting Rhythm and Pattern Generation with Cholinergic Modulation in Rhythmic Medullary Slices of Mice

Shivam Nipanikar, Ann L. Revill, Glauber da Silva, Daniel B. Zoccal

Obstructive Sleep Apnea (OSA) is characterized by repeated airway obstructions during sleep leading to cyclic reduced oxygen levels, known as chronic intermittent hypoxia (CIH), and frequent arousals. Insufficient neural control of upper airway muscles, especially the genioglossus, is the causative agent of …

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The Carotid Bodies are Required to Activate the Sympathetic Nervous System and Limit TNF-alpha Production During LPS-induced Systemic Inflammation

Tales F. V. Rosin, R. Morais, Isabela P. Leirão, Lais M. Cardoso et autres

A growing body of evidence has shown that peripheral systemic inflammation recruits central autonomic circuits that modulate innate immune responses. However, the body-brain pathways governing these neuroimmune interactions remain unclear. Studies indicate that the carotid bodies, a pair of highly perfused sensory …

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Effects of aging and CIH exposure on respiratory function, postsynaptic excitatory muscarinic receptor expression, and cholinergic inputs

Glauber da Silva, Daniel B. Zoccal, Vivian Biancardi, Ann L. Revill

Alzheimer’s disease (AD) is an irreversible neurodegenerative process that is often comorbid with several diseases, including Obstructive Sleep Apnea (OSA). An individual with AD is 5 times more likely to have OSA than a non-AD individual of similar age. OSA is characterized …

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Prenatal cannabinoid exposure affects central cardiorespiratory control in young male and female rats

Luís Gustavo A. Patrone, Marlusa Karlen‐Amarante, Luciane H. Gargaglioni, Daniel B. Zoccal

Cannabis use among pregnant women is rising globally; however, the impact on offspring's homeostatic physiological systems is still uncertain. We found that prenatal cannabinoid exposure impairs respiratory motor control in early adulthood. We also identified that sympathetic control is limited in juvenile …

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A comprehensive characterization of active expiration in freely behaving rats

Isabela P. Leirão, Pedro L. Katayama, Daniel B. Zoccal

ABSTRACT Blood gas disturbances caused by exposure to low oxygen (hypoxia) or high carbon dioxide levels (hypercapnia) lead to a compensatory increase in pulmonary ventilation. Among the motor changes supporting these reflex respiratory responses is the recruitment of abdominal muscles (ABD) during …

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Prenatal cannabinoid exposure affects central cardiorespiratory control in young male and female rats

Luís Gustavo A. Patrone, Marlusa Karlen‐Amarante, Luciane H. Gargaglioni, Daniel B. Zoccal

Abstract Cannabis use among pregnant women is rising globally, mainly for recreational and medical reasons to relieve symptoms like nausea, vomiting, anxiety, and insomnia. This trend is reinforced by the misconception that its natural origin guarantees safety, along with government policies promoting …

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