Janeta Nikolovski

Direct-to-Participant Enrollment in a Virtual Trial

Mellanie True Hills, Serge Korjian, Gerald Chi, Andrea Natale et autres

BACKGROUND: Decentralized clinical trials using direct-to-participant recruitment can potentially engage large, representative participant pools. OBJECTIVES: The objective of the study was to share insights on multichannel strategies for participant recruitment in the decentralized Heartline Study, a randomized trial testing the impact of …

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The Heartline Experience

Janeta Nikolovski, Ann Marie Návar, Steven R. Steinhubl, Katie Baca-Motes et autres

BACKGROUND: Digital health technologies can potentially improve clinical research efficiency and increase participant diversity but have challenges with long-term participant engagement. OBJECTIVES: The Heartline Study evaluated the impact of a mobile app-based heart health engagement program with the Irregular Rhythm Notification (IRN) …

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Research Exclusive Donation: Revolutionizing Medical Research through Organ Procurement Organizations

C. A. Hostetler, Richard A. Squires, L.W. Glenn, María Florencia Fernández et autres

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Identifying Failure Modes of Pancreatic Islet Cells during Cold Storage Using a Multi-Omics Approach

Nabil E. Boutagy, Lorna Glenn, Bill Nave, O. Severinchik et autres

Purpose: Pancreas transplantation is a curative solution for patients with Type 1 Diabetes. However, less than 1000 pancreas transplantations are conducted each year due to a lack of suitable organs. Approximately 30% of pancreases procured from deceased donors in the United States …

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Abstract 4143017: Insights for Direct-to-Patient Clinical Trial Recruitment Strategies From the Heartline Study

Mellanie True Hills, Serge Korjian, Gerald Chi, Andrea Natale et autres

Background: Decentralized clinical trials using direct-to-participant recruitment can potentially engage large, representative participant pools. Research Question: Can a decentralized clinical trial use a multichannel approach to recruit patients >65 years old across the United States? Goals/Aims: To share insights on multichannel strategies …

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Abstract 15144: The Heartline Experience: Can Digital Health Technology Trials Achieve Long-Term Participant Engagement?

Janeta Nikolovski, Ann Marie Návar, Steven R. Steinhubl, Katie Baca-Motes et autres

Background: Digital health technologies can potentially streamline clinical research and reach broad and diverse populations, yet they often fall short to achieve long-term participant engagement. Research Question: Can long-term participant engagement in a large, direct-to-participant randomized trial using an entirely decentralized trial …

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41991 Early skin surface biomarkers associated with risk susceptibility to atopic dermatitis in children with family history of allergic disease

Richard A. Insel, Takahiro Sato, Janeta Nikolovski, Russell A. Gould et autres

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Does early detection of atrial fibrillation reduce the risk of thromboembolic events? Rationale and design of the Heartline study

Charles Michael Gibson, Steven R. Steinhubl, Dhanunjaya Lakkireddy, Mintu P. Turakhia et autres

BACKGROUND: The impact of using direct-to-consumer wearable devices as a means to timely detect atrial fibrillation (AF) and to improve clinical outcomes is unknown. METHODS: Heartline is a pragmatic, randomized, and decentralized application-based trial of US participants aged ≥65 years. Two randomized …

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A randomized clinical study on the effects of emollient use on the developing infant skin microbiome and metabolome

Kimberly A. Capone, Diana Friscia, Janeta Nikolovski, Lorena S. Telofski et autres

There is little debate that the microbiome plays an overall role in health; however, there is much to be learned about potential factors influencing the microbiome, particularly that of the skin, since it has the most exposure to the environment. It has …

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Factors indicating intention to vaccinate with a COVID-19 vaccine among older U.S. adults

Janeta Nikolovski, Martin H. Koldijk, Gerrit Jan Weverling, John A. Spertus et autres

BACKGROUND: The success of vaccination efforts to curb the COVID-19 pandemic will require broad public uptake of immunization and highlights the importance of understanding factors associated with willingness to receive a vaccine. METHODS: U.S. adults aged 65 and older enrolled in the …

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Factors indicating intention to vaccinate with a COVID-19 vaccine among older U.S. Adults

Janeta Nikolovski, Martin H. Koldijk, Gerrit Jan Weverling, John A. Spertus et autres

A bstract BACKGROUND The success of vaccination efforts to curb the COVID-19 pandemic will require broad public uptake of immunization and highlights the importance of understanding factors associated with willingness to receive a vaccine. METHODS Adults enrolled in the Heartline™ clinical study …

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Effects of Emollient Use on the Developing Infant Skin Microbiome

Lorena S. Telofski, Kimberly A. Capone, Diana Friscia, Janeta Nikolovski

Purpose: Microbial colonization of skin begins with the first significant exposure at birth. Our previous work has demonstrated that although the skin microbiome evolves to an infant skin-like profile days after birth, the microbial community continues to evolve throughout a longer period …

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