Yoshinari Kawahara

Nationwide epidemiological survey of acute pancreatitis in Japan, 2021: the impact of the COVID-19 pandemic and revised clinical guidelines

Yuichi Tanaka, Atsushi Masamune, Ryotaro Matsumoto, Tetsuya Takikawa et autres

OBJECTIVES: This study aimed to clarify the current clinico-epidemiological characteristics of acute pancreatitis (AP) in Japan. METHODS: We conducted a two-stage nationwide survey of patients with AP treated at selected hospitals in 2021, during the COVID-19 pandemic. The first stage estimated the …

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Experience-Related Factors in the Success of Beginner Endoscopic Ultrasound-Guided Biliary Drainage: A Multicenter Study

Ryota Sagami, Kazuhiro Mizukami, Kazuhisa Okamoto, Chishio Noguchi et autres

Endoscopic ultrasound-guided biliary drainage (EUS-BD) has become comparable to endoscopic retrograde cholangiopancreatography and is now considered a first-line intervention for certain biliary obstructions. Although analysis of experience-related factors may help achieve better outcomes and contribute to its wider adoption, no concrete evidence …

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Potential association of eEF1A dimethylation at lysine 55 in the basal area of Helicobacter pylori-eradicated gastric mucosa with the risk of gastric cancer: a retrospective observational study

Yuka Hirashita, Masahide Fukuda, Masaaki Kodama, Yoshiyuki Tsukamoto et autres

BACKGROUND: Although eradication therapy for chronic Helicobacter pylori (H. pylori) reduces the risk of gastric cancer (GC), its effectiveness is not complete. Therefore, it is also critically important to identifying those patients who remain at high risk after H. pylori eradication therapy. …

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Potential Association of EEF1A Dimethylation at Lysine 55 in the Basal Area of Helicobacter Pylori-Eradicated Gastric Mucosa with the Risk of Gastric Cancer: A Retrospective Observational Study

Yuka Hirashita, Masahide Fukuda, Masaaki Kodama, Yoshiyuki Tsukamoto et autres

Abstract Background Although eradication therapy for chronic Helicobacter pylori reduces the risk of gastric cancer (GC), its effectiveness is incomplete. Therefore, it is critically important to identify those patients who remain at high risk after H. pylori eradication therapy. Accumulation of protein …

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Gastric mucosal changes, and sex differences therein, after Helicobacter pylori eradication: A long‐term prospective follow‐up study

Masaaki Kodama, Tadayoshi Okimoto, Kazuhiro Mizukami, Yuka Hirashita et autres

BACKGROUND AND AIM: Improvement of atrophic gastritis and intestinal metaplasia (IM) is considered to reduce the gastric cancer risk, but whether it can be achieved by H. pylori eradication (HPE) remains controversial. To evaluate the effect of HPE, we observed the gastric …

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Rectal varix treated with endoscopic cyanoacrylate injection therapy

Sotaro Ozaka, Yasuhiko Gotoh, Shunichiro Honda, T. Iwao et autres

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Helicobacter pylori infection modulates endogenous hydrogen sulfide production in gastric cancer AGS cells

Yoshinari Kawahara, Yuka Hirashita, Chikako Tamura, Yoko Kudo et autres

Abstract Background Persistent Helicobacter pylori infection induces gastric mucosal atrophy, which is a precancerous condition. Hydrogen sulfide (H2S), a gaseous biological transmitter, has been implicated in both the physiological functions of the gastrointestinal tract and its diseases. To understand gastric epithelial cell …

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Influence of acotiamide on 13C-urea breath test for Helicobacter pylori diagnosis

Kazuhiro Mizukami, Makoto Katsuta, Kazuhisa Okamoto, Kensuke Fukuda et autres

The Helicobacter pylori infection and functional dyspepsia are often coexisted. The effect of acotiamide, a drug for functional dyspepsia, on the result of Helicobacter pylori diagnosis has yet to be studied. We evaluated the influence of acotiamide on the results of Helicobacter …

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246 Helicobacter pylori Infection Increases the Risk of Colorectal Polyps: A Large Scale Case-Control Study

Yoshinari Kawahara, Masaaki Kodama, Kazuhiro Mizukami, Tomoko Saito et autres

INTRODUCTION: Persistent Helicobacter pylori ( H. pylori ) infection begins during childhood and can cause peptic ulcers and gastric cancer. It can also cause extra-gastric organ disease, including idiopathic thrombocytopenic purpura. Although some studies have indicated a correlation between H. pylori infection …

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Examine the Availability and Safety of Mucosal Cutting Biopsy Technique for Diagnosis of Gastric Submucosal Tumor

Kazuhiro Mizukami, Osamu Matsunari, Ryo Ogawa, Yuka Hirashita et autres

OBJECTIVES: Differentiating gastrointestinal stromal tumor (GIST) from other submucosal tumors (SMTs) is important in diagnosing SMT. GIST is an immunohistological diagnosis that cannot be made from images alone. Tissue sampling of tumor sites is thus becoming increasingly important. In this study, the …

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Differences in Helicobacter pylori and CagA antibody changes after eradication between subjects developing and not developing gastric cancer

Masaaki Kodama, Tadayoshi Okimoto, Kazuhiro Mizukami, Kensuke Fukuda et autres

We evaluated serological Helicobacter pylori and cytotoxin-associated gene A (CagA) antibodies and endoscopic atrophy after eradication to identify factors predicting post-eradication gastric cancer development. Thirty-five patients with successful eradiation were divided into the post-eradication gastric cancer (13 cases) and non-gastric cancer (22 …

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Endoscopic gastric mucosal atrophy as a predictor of colorectal polyps: a large scale case-control study

Yoshinari Kawahara, Masaaki Kodama, Kazuhiro Mizukami, Tomoko Saito et autres

Although some studies have indicated a correlation between Helicobacter pylori infection and the risk of colorectal neoplasms, these findings have not been consistent and are controversial. This case-control study aimed to investigate the association between endoscopic gastric mucosal atrophy and colorectal polyp …

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