Sergio Grutadauria

Hepatitis E Virus Infection in Patients With Chronic Liver Diseases: A Latin American Multicenter Study

Anabella Clara Fantilli, María Belén Pisano, Maribel Martínez Wassaf, Guadalupe Di Cola et autres

BACKGROUND: Hepatitis E virus (HEV) is a major cause of acute hepatitis worldwide, yet its impact in Latin America remains underexplored. Evidence suggests that chronic liver disease (CLD) patients infected with HEV face increased risks of disease progression and mortality. The PROGINS …

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P- 24 DISTRIBUTION OF HEPATITIS C GENOTYPES IN THE ARGENTINE POPULATION IN THE LAST TEN YEARS

Javier Alejandro Sfalcin, Alan Gomez, Tomás Fernández Aparicio, Dolores Gagey et autres

Hepatitis C virus (HCV) consists of 7 genotypes and multiple subtypes. With the introduction of pangenotypic direct-acting antivirals (DAAs), the utility of genotype as a prognostic factor for treatment tends to be less relevant. However, it is useful for those patients who …

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Persistence of measles neutralizing antibody related to vaccine and natural infection acquired before HIV infection

María B. Isa, Jorge Victorio Pavan, Paola Sicilia Don, Sergio Grutadauria et autres

Little is known about long-lasting measles protective immunity when exposure to wild-type or vaccine measles virus precedes HIV infection. The results obtained suggest that measles immunity wanes and the lowest measles geometric mean titres (GMT) were significantly associated with measles vaccine-induced immunity …

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[Distribution of genotypes of hepatitis C in the city of Córdoba, Argentina].

R D Ruíz, L B Bísaro, J C German, Sergio Grutadauria

BACKGROUND: Knowledge of Hepatitis C virus genotype (HCV) present in a patient has an epidemiological interest. In addition, it has an important prognostic value that guides the duration and success of treatment. AIMS: To analyze the distribution of genotypes in HCV-positive patients …

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A novel human adenovirus hexon protein of species D found in an AIDS patient

Leonardo Ferreyra, Miguel Oscar Giordano, Laura Cecilia Martínez, María B. Isa et autres

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[Human herpesvirus-6 circulation in healthy adults and oncologic patients].

Silvia Ethel Carricart, Dolores Bustos, Sergio Grutadauria, Silvia Viviana Nates et autres

The aim of this paper was to assess the prevalence of antibodies to HHV-6 in the general population and study the virus circulation among individuals with cancer, in order to analyze HHV-6 involvement in lymphoproliferative disorders. A total of 200 sera from …

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Evaluation of Antibodies against a Rubella Virus Neutralizing Domain for Determination of Immune Status

Patricia Alejandra Cordoba, Alejandra Lanoel, Sergio Grutadauria, Marta Zapata

The protective immune responses against rubella virus (RV) are related to its neutralizing epitopes, an issue that is important to consider when assessing the immune status of patients with remote infection. In the present paper, we compare the antibodies detected by a …

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Neutralizing Monoclonal Antibody to the E1 Glycoprotein Epitope of Rubella Virus Mediates Virus Arrest in VERO Cells

Patricia Alejandra Cordoba, Sergio Grutadauria, Cecilia Cuffini, Marta Zapata

The best-known mechanism of action of antibody-mediated virus neutralization is to impede the entrance of viruses to host cells, as determined by neutralization assays. Antibodies may also inhibit the exit of rubella virus (RV) from infected host cells; in this case, the …

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Analysis of viral glycoproteins by glycosidic digestion inside a polyacrylamide gel

Sergio Grutadauria, Viviana Castilla, Marta Zapata, Susana E. Mersich

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Cell-fusion assay for the detection of rubella virus in Vero cells

Sergio Grutadauria, Patricia Alejandra Cordoba, Cecilia Cuffini, Marta Zapata

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Presence of a neutralizing domain in isolates of rubella virus in Cordoba, Argentina

Patricia Alejandra Cordoba, Sergio Grutadauria, Cecilia Cuffini, Marta Zapata

We studied the presence of a neutralizing epitope of rubella virus (RV) in locally circulating strains in Cordoba, Argentina, using binding by the monoclonal antibody (MAb) H3. This epitope is contained in a sequence of the E1 glycoprotein (E1208-239) represented by the …

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Different Affinity of Monoclonal Antibodies for Conserved Neutralizing Epitopes on Two Strains of Rubella Virus

Patricia Alejandra Cordoba, Sergio Grutadauria, Cecilia Cuffini, Marta Zapata

There is, apparently, only one serological type of rubella virus (RV) in the population, although several isolates exist with different characteristics. Some authors failed to detect significant differences among RV strains by neutralization, hemagglutination inhibition, and enzyme immunoassay using polyclonal and monoclonal …

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