Kazufumi Ohmura

Transarterial Embolization via the Occipital Artery for a Posterior Condylar Canal Dural Arteriovenous Fistula Following Head Trauma

Yohei SHIMIZU, Kazufumi Ohmura, Daisuke Mizutani, Hideomi Kitajima

Posterior condylar canal dural arteriovenous fistula is rare, and cases of posterior condylar canal dural arteriovenous fistula directly related to trauma have been reported even less frequently. We describe a case of posterior condylar canal dural arteriovenous fistula that presented with tinnitus …

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Age‑dependent and post‑intraventricular hemorrhage remodeling of the ependymal glycocalyx in mice

Tomohiro Iida, K Mori, Hiroyuki Tomita, Kazufumi Ohmura et autres

BACKGROUND: The ependymal glycocalyx (Gcx) is a glycan-rich apical structure that lines the ventricular brain surface. It is thought to contribute to cerebrospinal fluid dynamics and brain homeostasis by forming a selective barrier, preserving surface charge, and supporting ciliary function. Despite its …

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Age‑Dependent and Post‑Intraventricular Hemorrhage Remodeling of the Ependymal Glycocalyx in Mice

Tomohiro Iida, K Mori, Hiroyuki Tomita, Ayumi Niwa et autres

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Comparative Analysis of Disposable Cranial Perforators in Trepanation

Kazufumi Ohmura, Noriyuki Nakayama, Tsuyoshi Izumo

BACKGROUND AND OBJECTIVES: Cranial trepanation is a fundamental neurosurgical procedure that has evolved significantly with the development of disposable cranial perforators designed to enhance safety and efficiency. The aim of this study was to evaluate and compare the safety, efficiency, and cost-effectiveness …

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Visualizing the endothelial glycocalyx in human glioma vasculature

Kazufumi Ohmura, Hiroyuki Tomita, Hideshi Okada, Noriyuki Nakayama et autres

Gliomas are the most common primary brain tumors in adults. However, glioblastoma is especially difficult to treat despite advancements in treatment. Therefore, new and more effective treatments are needed. The endothelial glycocalyx covers the luminal surface of the endothelium and plays an …

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10242- ML-11 A CASE OF PRIMARY CAVERNOUS SINUS MALIGNANT LYMPHOMA DIAGNOSED BY CRANIAL BIOPSY

Takeaki Tamura, Noriyuki Nakayama, Kazufumi Ohmura, Tetsuya Yamada et autres

Abstract BACKGROUND AND AIMS Following neuroimaging studies, stereotactic irradiation is frequently utilized to treat cavernous sinus tumors. However, differentiating these tumors presents a significant challenge due to the overlapping imaging characteristics of various benign and malignant conditions, including cavernous hemangiomas, pituitary adenomas, …

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Comparison of transposition and interposition methods in microvascular decompression for hemifacial spasm: an analysis of 109 cases performed by a single surgeon in a single-center retrospective study

Etsuko Owashi, Kazufumi Ohmura, Kenji Shoda, Tetsuya Yamada et autres

BACKGROUND: Microvascular decompression (MVD), the standard surgical approach for hemifacial spasm (HFS), can be divided into the interposition and transposition methods. Although the risk of HFS recurrence following interposition has been reported, there is limited data comparing long-term outcomes between both methods …

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Endothelial Glycocalyx in the Peripheral Capillaries is Injured Under Oxaliplatin-Induced Neuropathy

Takahiro Kuroda, Akio Suzuki, Hideshi Okada, Masayoshi Shimizu et autres

Oxaliplatin, a platinum-based anticancer drug, is associated with peripheral neuropathy (oxaliplatin-induced peripheral neuropathy, OIPN), which can lead to worsening of quality of life and treatment interruption. The endothelial glycocalyx, a fragile carbohydrate-rich layer covering the luminal surface of endothelial cells, acts as …

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Prevention of vincristine-induced peripheral neuropathy by protecting the endothelial glycocalyx shedding

Kazufumi Ohmura, Takamasa Kinoshita, Hiroyuki Tomita, Hideshi Okada et autres

Vincristine-induced peripheral neuropathy (VIPN) adversely affects the quality of life and treatment continuity of patients. The endothelial glycocalyx (eGCX) protects nerves from harmful substances released from the capillary vessels, but its role in peripheral neuropathy remains unclear. We investigated the impact of …

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Resection of positive tissue on methionine‐PET is associated with improved survival in glioblastomas

Kazufumi Ohmura, Takashi Daimon, Yuka Ikegame, Hirohito Yano et autres

Abstract Background and purpose The volume of excised tumor in contrast‐enhanced areas evaluated via magnetic resonance imaging is known to have a strong influence on the survival of patients with glioblastoma (GBM). In this study, we investigated the effect of tumor resection …

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Peritumoral Edema in Gliomas: A Review of Mechanisms and Management

Kazufumi Ohmura, Hiroyuki Tomita, Akira Hara

Treating malignant glioma is challenging owing to its highly invasive potential in healthy brain tissue and the formation of intense surrounding edema. Peritumoral edema in gliomas can lead to severe symptoms including neurological dysfunction and brain herniation. For the past 50 years, …

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Author response for "Resection of positive tissue on methionine‐PET is associated with improved survival in glioblastomas"

Kazufumi Ohmura, Takashi Daimon, Yuka Ikegame, Hirohito Yano et autres