Accès ouvert
2024
article
OpenAlex
A. Uitterlinden, Massimiliano Cocca, Maria Pina Concas, T.V. Duong et autres
The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular arrhythmia. Using genome-wide multi-ancestry analyses (>250,000 individuals) we identify 177, …
Accès ouvert
2024
article
OpenAlex
Pieter Sicco Hiemstra, Lies Lahousse, Henry Völzke, K. De Jong et autres
Background Forced Vital Capacity (FVC) is an important predictor of all-cause mortality in the absence of chronic respiratory conditions. Epidemiological evidence highlights the role of early life factors on adult FVC, pointing to environmental exposures and genes affecting lung development as risk …
Accès ouvert
2020
article
OpenAlex
N. Sotoodehnia, M. Eijgelsheim, C. Newton-Cheh, P. Navarro et autres
Higher resting heart rate is associated with increased cardiovascular disease and mortality risk. Though heritable factors play a substantial role in population variation, little is known about specific genetic determinants. This knowledge can impact clinical care by identifying novel factors that influence …