Accès ouvert
2026
article
OpenAlex
Hannah G. Tarolli, Andrew B. Harvey, Inara Devji, Raymond N. Deepe et autres
Cells derived from the endocardium, epicardium, cardiac neural crest, and second heart field play a critical role in the formation of the valvuloseptal structures of the heart. Previous studies have shown that the expression of the transcription factor SOX9 in these cell …
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Accès ouvert
2026
article
OpenAlex
Andrew B. Harvey, Jenna R. Drummond, Hannah G. Tarolli, Renélyn A. Wolters et autres
Background CD109 encodes a GPI-linked glycoprotein that acts as a signaling modulator in the TGF-β pathway. CD109 has emerged in several genome-wide association studies as linked to coronary artery disease, myocardial infarction, and angina pectoris. Heterozygous loss-of-function mutations in CD109 have also …
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Accès ouvert
2025
article
OpenAlex
Andrew B Harvey, Allison M. Trouten, Renélyn A. Wolters, Jenna R. Drummond et autres
The epicardium is the mesothelial lining of the heart and is a source of progenitor cells during heart development, giving rise to an invasive population of mesenchymal cells which differentiate into cardiac fibroblasts, mural cells, and other cell types essential for heart …
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Accès ouvert
2025
article
OpenAlex
Jenna R. Drummond, Raymond N. Deepe, Hannah G. Tarolli, Renélyn A. Wolters et autres
BACKGROUND: Previously, we explored the role of Sox9 in the second heart field (SHF) in atrioventricular septation. For that study, we created a SHF-specific Sox9 knockout mouse. In addition to the presence of primary atrial septal defects in half of the offspring, …
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Accès ouvert
2023
article
OpenAlex
Andrew B. Harvey, Renélyn A. Wolters, Raymond N. Deepe, Hannah G. Tarolli et autres
Epicardial-derived cells (EPDCs) are involved in the regulation of myocardial growth and coronary vascularization and are critically important for proper development of the atrioventricular (AV) valves. SOX9 is a transcription factor expressed in a variety of epithelial and mesenchymal cells in the …
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Accès ouvert
2022
article
OpenAlex
Raymond N. Deepe, Jenna R. Drummond, Renélyn A. Wolters, Emily A. Fitzgerald et autres
Failure to form the septal structures that separate the left and right cardiac chambers results in defects that allow shunting of blood from one side of the heart to the other, leading to the mixing of oxygenated and de-oxygenated blood. The atrioventricular …
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Accès ouvert
2021
article
OpenAlex
Renélyn A. Wolters, Ray Deepe, Jenna R. Drummond, Andrew B. Harvey et autres
This paper is dedicated to the memory of Dr. Adriana "Adri" Gittenberger-de Groot and in appreciation of her work in the field of developmental cardiovascular biology and the legacy that she has left behind. During her impressive career, Dr. Gittenberger-de Groot studied …
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Accès ouvert
2020
article
OpenAlex
Ray Deepe, Emily A. Fitzgerald, Renélyn A. Wolters, Jenna R. Drummond et autres
In this publication, dedicated to Professor Robert H. Anderson and his contributions to the field of cardiac development, anatomy, and congenital heart disease, we will review some of our earlier collaborative studies. The focus of this paper is on our work on …
us, nl
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