Suzanne Couzijn

Ferroptosis inhibition protects against α-synuclein-related neuronal cell death

Nad’a Majerníková, Maria João da Costa Caiado, Renée I. Seinstra, Suzanne Couzijn et autres

Parkinson's disease (PD), characterized by α-synuclein (α-syn) pathology, affects millions of people worldwide. While current treatments mainly symptomatically address the motor aspects of PD, they lack efficacy in delaying or halting the degenerative process. Ferroptosis, a type of programmed cell death characterized …

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Condensate-Driven Triglyceride Depletion Links α-Synuclein to Mitochondrial Dysfunction

Tao Zhang, María Eugenia Goya, Alejandro Herron-Bedoya, Jorien C. van der Weerd et autres

Summary Inclusions of α-Synuclein (αSyn) characterize multiple age-related neurodegenerative diseases, including Parkinson’s disease (PD) and Multiple System Atrophy (MSA). While interactions between αSyn and lipids are known to contribute to αSyn pathobiology, the precise cellular mechanisms that link lipids to αSyn toxicity …

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A sudden collapse: the disaggregation of amyloid fibres

Suzanne Couzijn, Ellen A. A. Nollen

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Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome

Wouter Huiting, Suzanne L. Dekker, Joris CJ van der Lienden, Rafaella Mergener et autres

A loss of the checkpoint kinase ataxia telangiectasia mutated (ATM) leads to impairments in the DNA damage response, and in humans causes cerebellar neurodegeneration, and an increased risk of cancer. A loss of ATM is also associated with increased protein aggregation. The …

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Author response: Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome

Wouter Huiting, Suzanne L. Dekker, Joris CJ van der Lienden, Rafaella Mergener et autres

Various genotoxic stresses trigger widespread aggregation of abundant, liquid-liquid phase separation-prone proteins, suggesting that genotoxic stress is a potential driver of disease-associated protein aggregation.

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Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome

Wouter Huiting, Suzanne L. Dekker, Joris CJ van der Lienden, Rafaella Mergener et autres

ABSTRACT A loss of the checkpoint kinase ATM leads to impairments in the DNA damage response, and in humans causes cerebellar neurodegeneration, and a high risk to cancer. A loss of ATM is also associated with increased protein aggregation. The relevance and …

nl, us (code pays fourni par la source)